Drinking tea is an important cultural and sensory activity in modern society. However, consumption may influence biological functions because of its high polyphenol methylxanthine content. Theophylline a that plays significant role respiratory physiology used clinically as bronchodilator. In this study, we assessed the pharmacological safety theophylline by investigating effects on responses experimental rodents. Six-week-old male Sprague-Dawley rats were intravenously administered 0, 2.5,...

Obesity is closely associated with low-grade chronic and systemic inflammation dyslipidemia, the consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) may modulate obesity-related disorders, such as dyslipidemia. An emerging research question to understand dietary intervention strategy that more important regarding n-3 PUFA consumption: (1) a lower ratio n-6/n-3 PUFAs or (2) higher amount consumption. To desirable method consumption, we replaced lard from experimental diets either...

As caffeine consumption continues to increase, both positive and negative effects are becoming evident. Caffeine directly affects the cardiovascular system, including heart function rate. Thus, understanding current respiratory safety pharmacological responses is of utmost importance. To elucidate characteristics caffeine, male Sprague–Dawley rats, aged 6 weeks, were intravenously administered doses 0, 2, 6, 20 mg/kg caffeine. Respiratory rate, tidal volume, minute volume subsequently...

The bovine serum albumin (BSA)-epigallocatechin gallate (EGCG) nanoparticles were fabricated using a desolvation method, and coated with poly-ε-lysine or chitosan. BSA-EGCG (BEN), (PBEN), chitosan (CBEN) had spherical morphology size of 186, 259, 300 nm, respectively. loading efficiency EGCG in these was 32.3%, 35.4%, 32.7%, whereas the capacity 18.9%, 17.0%, 16.0% (w/w), Poly-ε-lysine coating prevented aggregation at pH 4.5-5.0. However, they caused particle 6.5-7.0. BEN negative...

Adult humans have a substantial amount of inducible-brown (or beige) fat, which is associated with increased energy expenditure and reduced weight gain via thermogenesis. Despite the identification key regulators beige adipogenesis, impacts dietary factors on adaptive thermogenesis are largely unknown, partly due to lack validated human cell models. Bone morphogenetic protein 7 (BMP7) known promote brown adipogenesis in rodent progenitor cells. However, controversy still surrounds cellular...

Iron-copper interactions were described decades ago; however, molecular mechanisms linking the two essential minerals remain largely undefined. Investigations in humans and other mammals noted that copper levels increase intestinal mucosa, liver blood during iron deficiency, tissues all important for homeostasis. The current study was undertaken to test hypothesis dietary influences homeostasis deficiency overload. We thus fed weanling, male Sprague-Dawley rats (n = 6-11/group) AIN-93G-based...

In this study, we investigated the physicochemical and antioxidative properties of traditional Korean confectionery, Yanggaeng, when various amounts tempeh powder (TP) were added.We replaced a portion white bean paste in Yanggaeng with TP at percentages 0% (CON), 2% (TP2), 4% (TP4), 6% (TP6) by total weight.The proximate composition results showed that TP6 exhibited highest crude ash protein contents, but its moisture content carbohydrate lowest compared to CON.Tempeh addition altered...

Objective— Excessive caloric intake is associated with obesity and adipose tissue dysfunction. However, the role of dietary cholesterol in this process unknown. The aim study was to determine whether increasing alters content, adipocyte size, endocrine function nonhuman primates. Approach Results— Age-matched, male African Green monkeys (n=5 per group) were assigned 1 3 diets containing 0.002 (low [Lo]), 0.2 (medium [Med]), or 0.4 (high [Hi]) mg cholesterol/kcal. After 10 weeks diet feeding,...

Objectives: This study aimed to identify dietary factors influencing long-term body weight variability and their potential implications for various health outcomes.Methods: Data from the Korean Genome Epidemiology Study, a large-scale cohort of middle-aged Koreans, were analyzed examine relationship between intake intra-individual variability. The analysis focused on identifying specific that modulate body-weight over time.Results: Significant gender-specific differences observed in...

Background/Objectives: Obesity is a key factor in metabolic syndrome (MetS) development. Consumption of high-fat diet (HFD) accelerates the onset obesity and associated complications. Protaetia brevitarsis (PB) has been traditionally utilized Korean medicine for its antioxidant, anti-diabetic, anticancer, hepatoprotective effects. However, specific effects PB hydrolysate on skeletal muscles have not fully elucidated. Therefore, this study sought to assess influence HFD-induced MetS, focusing...

This study examined the effects of alternative sweeteners—allulose, stevia, and xylose—on physicochemical, textural, sensory properties Yanggaeng fortified with 2% Corni fructus powder (CF). A proximate composition analysis revealed that treated sweeteners had a significantly higher moisture content lower carbohydrate than sugar. Colorimetric showed xylose decreased lightness (L*) increased redness (a*) yellowness (b*), likely due to enhanced browning reactions. The exhibited highest Brix...

Inflammatory responses are key pathological factors in various canine diseases, making the control of inflammatory vital for health. This study examined anti-inflammatory effects rutin on DH82 cells, a type macrophage, against lipopolysaccharide (LPS)-induced responses. The vitro experimental model was established by stimulating macrophage cells with LPS. To evaluate inflammation-preventative rutin, analyses were conducted using enzyme-linked immunosorbent assay, western blot, and real-time...

The aim of this study was to determine the anti-inflammatory and anti-endoplasmic reticulum (ER) stress effects Aruncus dioicus var. kamtschaticus (ADK) extract on ARPE-19 cells. Pretreatment with ADK effectively mitigated thapsigargin (Tg)-induced increases in vascular endothelial growth factor protein secretion intracellular calcium levels. Furthermore, pretreatment suppressed ocular ER stress-related expression a dose-dependent manner, inhibited loss tight junctions, interleukin-6 gene...

Chronic stress in the central nervous system can lead to neurological dysfunction characterized by spontaneous neuronal cell death. This study investigated neuroprotective potential of an aqueous extract Lilium lancifolium Thunberg (ELL) against corticosterone (CORT)-induced pathophysiology PC12 cells. To assess effects ELL, cells were pretreated with 50 µg/mL ELL before being exposed CORT. significantly prevented CORT-induced death attenuating pro-apoptotic protein expression, lactate...

Metabolic syndrome (MetS) is a growing global health concern, driven in part by increasing rates of overweight and obesity. In Korea, MetS incidence escalates particularly among middle-aged women, eventually surpassing that men. While protein-rich diets have been associated with improved metabolic health, the impact protein intake on body weight fluctuations (BWFs) risk has received limited attention, especially Korean populations. Using data from Genome Epidemiology Study (KoGES), this...

This study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental were randomly assigned four groups (n = 8 per group) and received at dose 0, 5, 10, or 20 mg/kg. Functional behaviors observed 0.25, 1.5, 6, 24 h after administration. Among hand-held observations, ease removal from cage handling significantly altered in all caffeine-exposed both...

In this study, we evaluated the safety pharmacological effects and potential adverse reactions of orally administered theophylline. Theophylline, a commonly used bronchodilator, is xanthine derivative that exerts stimulatory on central nervous system. Using an experimental rat model, explored impact theophylline respiratory parameters, including rate, tidal volume, minute volume. Thirty-two 6-week-old male Sprague-Dawley rats were randomly divided into control groups. The group received...

This study evaluated the effects of Guatemalan coffee extract (G) on physicochemical, antioxidant, and sensory properties Yanggaeng at different roasting levels (light, medium, dark) concentrations (0%, control group [CON]; 2%, 2; 4%, 4; 6%, 6). Moisture, ash, fat, protein, carbohydrate contents varied significantly with G concentration level, light roasts exhibiting highest moisture fat content, but lowest ash content. Colorimetric showed a dose-dependent decrease in lightness an increase...

The objective of this study was to evaluate the effects supplementing quercetin extracted from Sophora japonica flower (QS) diet broiler chicks on their growth performance, apparent nutrient digestibility, cecal microbiota, serum lipid profiles, relative organ weight, and breast muscle quality.A total 1,088 1-day-old (mixed sex) were randomly assigned four groups based initial body weight (43.00±0.29 g). experimental period 35 days (starter, 0 7; grower, 7 21; finisher, 21 35). There 17...

The inhalation of fine particulate matter (PM) is a significant health-related environmental issue. Previously, we demonstrated that repeated PM exposure causes hyperlocomotive activity in mice, as well inflammatory and hypoxic responses their lungs. In this study, evaluated the potential efficacy ellagic acid (EA), natural polyphenolic compound, against PM-induced pulmonary behavioral abnormalities mice. Four treatment groups were assigned study (n = 8): control (CON),...