A5059051198- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Uterine Myomas and Treatments
- Tumors and Oncological Cases
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging and Pathology Studies
- Ovarian cancer diagnosis and treatment
- Orthopedic Infections and Treatments
- Urologic and reproductive health conditions
- Soft tissue tumor case studies
- IgG4-Related and Inflammatory Diseases
- Oral and Maxillofacial Pathology
- Histiocytic Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Soft tissue tumors and treatment
- Infective Endocarditis Diagnosis and Management
- Neuroblastoma Research and Treatments
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
- Renal and related cancers
- Cutaneous lymphoproliferative disorders research
Dartmouth–Hitchcock Medical Center
2023-2025
Dartmouth College
2024
Dartmouth Health
2024
Dartmouth Psychiatric Research Center
2024
Mayo Clinic in Arizona
2017-2023
Bipar
2022
Vanderbilt University Medical Center
2020-2022
Cedars-Sinai Medical Center
2022
Mayo Clinic in Florida
2017
WinnMed
2015
GLI1 -altered mesenchymal tumor is a recently described distinct pathologic entity with an established risk of malignancy, being defined molecularly by either gene fusions or amplifications. The clinicopathologic overlap tumors driven the 2 seemingly mechanisms activation still emerging. Herein, we report largest series confirmed neoplasms to date, including 23 GLI1- amplified and 15 -rearranged new cases, perform comparative clinicopathologic, genomic, survival investigation. rearranged...
Despite significant advances in their molecular pathogenesis, skeletal vascular tumors remain diagnostically challenging due to aggressive radiologic appearance and morphologic overlap. Within the epithelioid category at benign end of spectrum, recurrent FOS/FOSB fusions have defined most hemangiomas, distinguishing them from hemangioendothelioma angiosarcoma. More recently, presence EWSR1/FUS :: NFATC1/2 emerged as genetic hallmark a novel group unusual proliferations, often displaying...
Glomus tumors are rare mesenchymal neoplasms with a phenotype akin to the modified smooth muscle cells of glomus body. Most benign, but examples show malignant histologic characteristics and aggressive behavior. We recently encountered tumor BRAF V600E mutation. sought study large cohort for this mutation, particular attention associated characteristics. Tumors were classified based on WHO criteria as uncertain potential (glomus potential-GT-UMP), or malignant. screened by...
Uterine leiomyomas, in contrast to sarcomas, tend cease growth following menopause. In the setting of a rapidly enlarging uterine mass postmenopausal patient, clinical distinction leiomyoma from sarcoma is difficult and requires pathologic examination. A 74-year-old woman presented with bleeding acute blood loss requiring transfusion. She was found have clinically suspicious for sarcoma. An abdominal hysterectomy bilateral salpingo-oophorectomy were performed. 15.5 cm partially necrotic...
Abstract An increasing number of epithelioid vascular lesions, in particular tumors from the benign and low‐grade end spectrum, have been characterized by recurrent gene fusions. As a result, detection these molecular markers improved classification diagnostically challenging cases. However, despite significant progress, there are occasional lesions that do not fit known histologic or groups. Herein, we present five such unclassified which occurred bone showed distinct morphology composed...
Abstract Endometrial stromal sarcomas (ESS) are morphologically and molecularly heterogeneous. We report novel gene fusions ( EPC1::EED , EPC1::EZH2 ING3::PHF1 ) identified by targeted RNA sequencing in five cases. The ING3::PHF1‐ fusion positive ESS presented a 58‐year‐old female as extrauterine mesocolonic, ovarian masses, displayed large, monomorphic ovoid‐to‐epithelioid cells arranged solid sheets. patient remained alive with disease 13 months after surgery. three occurred the uterine...
ABSTRACT Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that can locally recur and potentially metastasize. Approximately 50% of IMTs harbor rearrangements in the gene encoding anaplastic lymphoma kinase ( ALK ), receptor tyrosine be therapeutically targeted with inhibitors (TKIs). With successful application TKI ALK‐positive nonsmall cell carcinoma (NSCLC), are often first‐line treatments for patients unresectable or metastatic IMTs. Although acquired resistance to...
Despite the release of anatomic site-specific staging systems for soft tissue sarcomas in eighth edition American Joint Committee on Cancer (AJCC) Staging Manual , algorithms arising extremities/trunk and retroperitoneum differ only lymph node metastasis. The not provides a larger potential space tumor growth before clinical presentation, but its complexities complicate surgical resection adversely affect disease-free survival. Here, we propose new system MDM2 -amplified liposarcomas...
Abstract Application of molecular testing in clinical practice has led to significant advances the classification soft tissue sarcomas. Despite remarkable progress, there are still challenging cases that remain unclassified. In this study, we present an unusual spindle cell sarcoma arising abdominal cavity a 37‐year‐old female. An extensive panel immunostains was nonspecific for line differentiation and tumor subjected targeted RNA sequencing further classification. The findings showed novel...
Prognostic factors for pleomorphic dermal sarcoma, a rare undifferentiated neoplasm of the skin, are poorly defined, and typical staging systems do not appear to be appropriate these neoplasms. We; therefore, sought identify prognostic disease-specific survival predictors metastasis. Pleomorphic sarcomas were identified in Surveillance, Epidemiology End Results database (N=1911). Multiple imputation was used overcome inherent limitations this dataset assess using multivariable Cox...
ABSTRACT Conventional high‐grade osteosarcomas are characterized by aggressive radiologic features, cytologic pleomorphism, and complex genomics. However, rare examples of remain challenging due to unusual histology, such as sclerosing or osteoblastoma‐like which may require molecular confirmation their genetic alterations. We have encountered a case in 17‐year‐old man, who presented with third metatarsal sclerotic bone lesion, found incidentally the work‐up foot trauma. The initial imaging...