A5081351459- HIV Research and Treatment
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Genetic diversity and population structure
- Fish biology, ecology, and behavior
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Identification and Quantification in Food
- Immune responses and vaccinations
- Autoimmune Neurological Disorders and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Advanced Biosensing Techniques and Applications
- Genetic factors in colorectal cancer
- Gynecological conditions and treatments
- Peripheral Neuropathies and Disorders
- Uterine Myomas and Treatments
- Cellular transport and secretion
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Digestive system and related health
- Cancer Research and Treatments
- Genomic variations and chromosomal abnormalities
- Fish Biology and Ecology Studies
Mayo Clinic in Florida
2024
Emory University
2022-2024
Mayo Clinic in Arizona
2019-2020
Georgia Institute of Technology
2017-2018
Intrathecal synthesis of central nervous system (CNS)-reactive autoantibodies is observed across patients with autoimmune encephalitis (AE), who show multiple residual neurobehavioral deficits and relapses despite immunotherapies. We leveraged two common forms AE, mediated by leucine-rich glioma inactivated-1 (LGI1) contactin-associated protein-like 2 (CASPR2) antibodies, as human models to comprehensively reconstruct profile cerebrospinal fluid (CSF) B cell receptor (BCR) characteristics....
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interactions, vaccine priming HCDR3-dominant bnAbs germline-targeting has not been demonstrated in humans or outbred animals. In this work, immunization with N332-GT5, an envelope trimer designed target precursors bnAb BG18, primed...
The thousands of species closely related cichlid fishes in the great lakes East Africa are a powerful model for understanding speciation and genetic basis trait variation. Recently, genomes five African cichlids representing distinct lineages were sequenced used to predict protein products at genome-wide level. Here we characterize evolutionary relationship each previously animal species. We Treefam database, set preexisting phylogenies built using 109 genomes, identify families annotated...
Uterine leiomyomas, in contrast to sarcomas, tend cease growth following menopause. In the setting of a rapidly enlarging uterine mass postmenopausal patient, clinical distinction leiomyoma from sarcoma is difficult and requires pathologic examination. A 74-year-old woman presented with bleeding acute blood loss requiring transfusion. She was found have clinically suspicious for sarcoma. An abdominal hysterectomy bilateral salpingo-oophorectomy were performed. 15.5 cm partially necrotic...
Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immunization study in rhesus macaques (RM) using T/F Env sequences two human subjects, one of whom potent and broad neutralizing antibodies (Z1800M) while the other little no antibody responses (R66M) during infection. Using a DNA/MVA/protein protocol,...
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaques; yet from only animals neutralized the autologous virus. Here, we used high throughput immunoglobulin receptor and single cell RNA sequencing to characterize overall expansion, recall, maturation longitudinally over 90 weeks. Diversification...
ABSTRACT Background The thousands of species closely related cichlid fishes in the great lakes East Africa are a powerful model for understanding speciation and genetic basis trait variation. Recently, genomes five African cichlids representing distinct lineages were sequenced used to predict protein products at genome-wide level. Here we characterize evolutionary relationship each previously animal species. Results We Treefam database, set preexisting phylogenies built using 109 genomes,...