A5045379638- Nanoplatforms for cancer theranostics
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Hedgehog Signaling Pathway Studies
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Genetic factors in colorectal cancer
- Ubiquitin and proteasome pathways
- Bone Metabolism and Diseases
- Cytokine Signaling Pathways and Interactions
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Pharmacological Effects of Medicinal Plants
- Cell death mechanisms and regulation
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- Bioactive Compounds and Antitumor Agents
- Retinoids in leukemia and cellular processes
- Cancer Cells and Metastasis
Rajiv Gandhi Centre for Biotechnology
2015-2024
Aneurin Bevan University Health Board
2024
Regional Centre for Biotechnology
2024
The University of Texas MD Anderson Cancer Center
2006-2023
University of Kerala
2006-2021
Mayo Clinic in Arizona
2020
Scuola Internazionale Superiore di Studi Avanzati
2007-2012
Italian Institute of Technology
2009-2012
Mayo Clinic
2012
Radboud University Nijmegen
2010
Abstract Purpose: Curcumin, a component of turmeric, has been shown to suppress inflammation and angiogenesis largely by inhibiting the transcription factor nuclear factor-κB (NF-κB). This study evaluates effects curcumin on ovarian cancer growth using an orthotopic murine model cancer. Experimental Design: In vitro in vivo experiments with without docetaxel were done human cell lines SKOV3ip1, HeyA8, HeyA8-MDR athymic mice. NF-κB modulation was ascertained electrophoretic mobility shift...
Abstract The activation of signal transducers and activators transcription 3 (STAT3) has been linked with the proliferation a variety human cancer cells, including multiple myeloma. Agents that can suppress STAT3 have potential for prevention treatment cancer. In present report, we tested an agent, ursolic acid, found in basil, apples, prunes, cranberries, its ability to activation. We pentacyclic triterpenoid, inhibited both constitutive interleukin-6–inducible dose- time-dependent manner...
Taxol is the best anticancer agent that has ever been isolated from plants, but its major disadvantage dose-limiting toxicity. In this study, we report with mechanism-based evidence curcumin, a nontoxic food additive commonly used by Indian population, sensitizes tumor cells more efficiently to therapeutic effect of Taxol. A combination 5 nm microm curcumin augments effects than alone as evidenced increased cytotoxicity and reduced DNA synthesis in HeLa cells. Furthermore, our results reveal...
Tumor recurrence after chemotherapy or radiation remains a major obstacle to successful cancer treatment. A subset of cells, termed stem can elude conventional treatments and eventually regenerate tumor that is more aggressive. Despite the large number studies, molecular events govern emergence aggressive therapy-resistant cells with cell properties are poorly defined. The present study provides evidence for rare escape from drug-induced death, an intermediate stay in non-cycling senescent...
Abstract Purpose: Capsaicin, a constituent of green and red peppers, has been linked with suppression tumorigenesis through mechanism that is not well understood. Because the transcription factor signal transducer activator 3 (STAT3) closely tumorigenesis, we investigated effect this vanilloid on STAT3 pathway in human multiple myeloma cells. Experimental Design: The capsaicin both constitutive interleukin-6–induced activation, associated protein kinases, STAT3-regulated gene products...
Keywords: 5-FU, poly (D, L-lactic-co-glycolic acid), controlled release
A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application investigated by photophysical in vitro studies. High singlet oxygen quantum yield water at longer wavelength promising IC(50) values a panel cancer cell lines ensure potential candidacy sensitizer as PDT drug. Reactive species (ROS) generation on MDA-MB 231 cells apoptotic pathway death illustrated using different techniques.
Deguelin, a constituent of the bark African plant Mundulea sericea (Leguminosae), exhibits antiproliferative and anticarcinogenic activities through mechanism that is not well understood. Because various steps in carcinogenesis are regulated by NF-kappaB, we postulated activity deguelin mediated this transcription factor. We found suppressed NF-kappaB activation induced carcinogens, tumor promoters, growth factors, inflammatory stimuli. This suppression was cell-type specific, because both...
Abstract Activation of signal transducers and activators transcription-3 (STAT-3) has been linked with survival, proliferation, chemoresistance, angiogenesis tumor cells, including human multiple myeloma (MM). Thus, agents that can suppress STAT3 activation have potential as cancer therapeutics. In our search for such agents, we identified acetyl-11-keto-β-boswellic acid (AKBA), originally isolated from Boswellia serrata. Our results show AKBA inhibited constitutive in MM cells. suppressed...
Photodynamic therapy (PDT) emerged as a promising cancer therapeutic technique due to the prospect of triggering and controlling drug action with light, which will reduce detrimental side effects traditional chemotherapy. In recent years, in PDT design, progressive approaches such use nanocarriers targeted delivery systems have been achieved improve bioavailability efficacy therapy. Herein, we report synthesis, photophysical, photobiological properties graphene oxide quantum dot (GQD)–BODIPY...
Abstract Gum arabic/acacia (GA), derived from Acacia trees, is a versatile natural product offering broad spectrum of applications. Its rich content soluble dietary fibers, coupled with low caloric profile, renders GA valuable component associated numerous health benefits. Furthermore, its fermentation by gut microbiota yields short‐chain fatty acids, renowned for their positive impact on health. Immunomodulation, crucially regulated mechanism in the body, serves to fend off pathogenic...
The molecular mechanisms of migraine pain are incompletely understood, although mediators such as NGF and calcitonin gene-related peptide (CGRP) believed to play an algogenic role. Although block is proposed a novel analgesic approach, its consequences on nociceptive purinergic P2X receptors trigeminal ganglion neurons remain unknown. We investigated whether neutralizing might change the function 3 natively coexpressed with cultured mouse neurons. Treatment antibody (24 h) decreased...
Photodynamic therapy (PDT) is a clinically established and highly evolving treatment modality for cancer. PDT utilizes light responsive drug called photosensitizer that selectively destroys tumor cells upon irradiation. Squaraines are class of dyes possessing all favorable characteristics have been considered to be potent candidate next generation PDT. In this study we chose an iodo derivative squaraine diiodo-squaraine (bis(3, 5-diiodo-2,4,6-trihydroxyphenyl)squaraine) which has reported...