A5031951805- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- BRCA gene mutations in cancer
- Synthesis and Biological Evaluation
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Phytochemistry and biological activity of medicinal plants
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Asymmetric Synthesis and Catalysis
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Synthetic Organic Chemistry Methods
- PARP inhibition in cancer therapy
- Synthesis of Indole Derivatives
- Catalytic C–H Functionalization Methods
- Orbital Angular Momentum in Optics
- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Cyclopropane Reaction Mechanisms
- Neurotransmitter Receptor Influence on Behavior
Rajiv Gandhi Centre for Biotechnology
2015-2024
Regional Centre for Biotechnology
2024
Nethradhama Superspeciality Eye Hospital
2023
Creative Commons
2023
Sankara Nethralaya
2023
Sri Konda Laxman Telangana State Horticultural University
2023
University of Kerala
2001-2022
Indian Institute of Technology Madras
2016-2018
Kamineni Institute of Dental Sciences
2018
Physical Research Laboratory
2017
Abstract There is an emerging evidence that plumbagin (5‐hydroxy‐2‐methyl‐1, 4‐naphthoquinone) may have potential as a chemotherapeutic agent. However, the growth inhibitory mechanisms of remained unexplored. The aim study was to determine whether plumbagin‐induced cell death in human cervical cancer line, ME‐180, exhibited biochemical characteristics apoptosis and check N ‐acetyl‐ l ‐cysteine (NAC), which free radical scavenger, can reverse cytotoxic effects plumbagin. It be concluded from...
Nimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition cyclin A leading S phase arrest. It also caused activation caspase-mediated apoptosis the ERK1/2 and p38 JNK1/2. Further retarded tumor migration invasion metalloproteinase-2/9 (MMP-2/9) expression, both at mRNA protein level. was strong inhibitor VEGF promoter activity,...
Angiogenesis is a hallmark of tumor development and metastatic progression, anti-angiogenic drugs targeting the VEGF pathway have shown to decrease disease progression in cancer patients. In this study, we analyzed anti-proliferative property plumbagin cisplatin sensitive, BRCA2 deficient, PEO-1 resistant, proficient PEO-4 ovarian cells. Both cells are sensitive irrespective status both normoxia hypoxia. Importantly, treatment effectively inhibits VEGF-A Glut-1 We also p53 mutant, OVCAR-5...
Aloe emodin (AE), a natural anthraquinone, is reported to have antiproliferative activity in various cancer cell lines. In this study, we analyzed the molecular mechanisms involved growth-inhibitory of hydroxyanthraquinone colon cell, WiDr. our observation AE inhibited proliferation by arresting cycle at G2/M phase and inhibiting cyclin B1. appreciably induced death specifically through induction apoptosis activating caspases 9/6. Apoptotic execution was found be solely dependent on...
In the world of medical literature, little has been reported about fears patients undergoing bronchoscopy. The aim this study was to identify common fibreoptic bronchoscopy and determine whether any factors might contribute reducing these fears. One hundred four consecutive were interviewed. Sixty one expressed fear procedure, as follows: afraid pain (33); breathing difficulties (11); oropharyngeal irritation (5); findings (2); sedation, cross-infection nasal lignocaine spray, respectively...
Abstract Radiotherapy is the primary line of cancer treatment for cervical and known to induce cell death in tumors. however limited by total dose that can be given without damaging normal tissue. Plumbagin, a naturally occurring naphthaquinone, has been reported have free radical producing properties. Hence we hypothesized plumbagin could also properties modify effects radiation on cells. Radiation combination with may thus augmenting effects. Results from our studies shown lower apoptosis...
The present study evaluated the ability of methanolic extract Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as most sensitive line for vitro growth inhibitory activity. C. induced indicated by nuclear condensation, increased annexin staining, loss mitochondrial membrane potential and induction DNA breaks identified TUNEL reactivity. It is possible that use a component herbal medicines could be justifiable.Key words:...
Phenylpropanoids and flavonoids are specialized metabolites that play a crucial role in plant defenses against biotic abiotic stresses. Secondary plants, such as phenylpropanoids, flavonoids, lignins, monolignols, phenolic acids, stilbenes coumarins, significant stress responses interactions with their environment. Under stress-free conditions, influence pollen tube growth, seed maturation, dormancy, the longevity of reproductive organs seeds. adverse can mediate defense responses,...
Abstract 2-Arylaminoquinoxalines were prepared by the condensation of 2-chloroquinoxaline with appropriate Mannich bases in presence HCl. To synthesize bases, 4-acetamidophenol was reacted formaldehyde and dialkylamine to yield 3-[(dialkylamino) methyl]-4-hydroxyacetanilide, followed hydrolysis. Antimalarial activities new arylaminoquinoxalines evaluated against rodent malaria parasite Plasmodium yoelii at a dose 75 mg kg−1. Three compounds synthesized (2-[3-[(diethylamino)...
Studies over the past decade and half have identified cancer stem cells (CSCs) to be responsible for tumorigenesis, invasion, sustenance of metastatic disease, radio- chemo-resistance tumor relapse. Recent reports described plasticity breast CSCs (BCSCs) shift between epithelial mesenchymal phenotypes via Epithelial-Mesenchymal Transition (EMT) Mesenchymal-Epithelial (MET) states as reason their invasive capabilities. Additionally, BRCA1 has been found a mammary cell fate determinant....