A5008627859- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Asymmetric Hydrogenation and Catalysis
- Marine Sponges and Natural Products
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Traditional and Medicinal Uses of Annonaceae
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Cyclization and Aryne Chemistry
- Organoboron and organosilicon chemistry
- Cancer Treatment and Pharmacology
- Alkaloids: synthesis and pharmacology
- Catalytic Alkyne Reactions
- Ionic liquids properties and applications
Indian Institute of Chemical Technology
2015-2024
Academy of Scientific and Innovative Research
2015-2024
University of Washington
2024
Robert Bosch (Germany)
2021
Wyoming Department of Education
2021
University of Wyoming
2021
Northeast Normal University
2021
Shanghai Institute of Organic Chemistry
2021
Benemérita Universidad Autónoma de Puebla
2021
Loughborough University
2021
[reaction: see text] PEG has been used as a solvent medium for regioselective Heck reactions with easy recyclability of and Pd catalyst the first time.
Transforming growth factor-β (TGF-β) regulates osteoclastogenesis and osteoclast survival, in part through the induction of osteoprotegerin (OPG), a protein known to inhibit formation function. To explore molecular basis TGF-β regulation OPG expression, we evaluated effects on formation, secretion, mRNA gene transcription. The marked inhibitory effect differentiation was confirmed co-culture model utilizing murine stromal/osteoblastic BALC cells bone marrow hematopoietic precursors. This...
The 8p12 locus (containing the FGFR1 tyrosine kinase gene) is frequently amplified in squamous cell lung cancer. However, it currently unknown which of 8p12-amplified tumors are also sensitive to fibroblast growth factor receptor (FGFR) inhibition. We found that, contrast with other recurrent amplifications, region included multiple centers amplification, suggesting marked genomic heterogeneity. FGFR1-amplified tumor cells were dependent on FGFR ligands vitro and vivo. Furthermore, ectopic...
The formal total synthesis of pentacyclic core alkaloid, (±)-cephalotaxine is achieved in nine steps from known 2-allylpyrrolidine-2-carboxaldehyde using aryne insertion reaction as a key step 10% overall yield. developed novel strategy enabled easy access to cephalotaxine congeners.
Osteoprotegerin (OPG) is a potent inhibitor of osteoclast formation and function. To elucidate how OPG regulated in bone, we examined (1) the expression localization protein bone tissue, (2) effect human parathyroid hormone 1-38 (hPTH 1-38) on messenger RNA (mRNA) levels rat femur metaphyseal diaphyseal (3) hPTH(1-38) mRNA cultured osteoblast-like cells derived from metaphysis diaphysis, ROS 17/2.8 osteosarcoma cells. Because PTH has been shown to stimulate osteoblast activity via cyclic...
PEG (400) has been used as a recyclable and rapid reaction medium for the asymmetric dihydroxylation of olefins; Sharpless ligand is efficiently recovered recycled with good enantioselectivity.
The polymethylhydrosiloxane-B(C(6)F(5))(3) combination is found to be a versatile carbonyl defunctionalization system under mild and rapid conditions. For the first time, B(C(6)F(5))(3) has been used as nonconventional Lewis acid catalyst activate PMHS. Aromatic aliphatic compounds were effectively reduced give corresponding alkanes in high yields.
The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via cascade [2+2] followed by a [4+1] annulation on arynes. overall transformation proceeded through formation ortho-quinone methide insertion transient aryne into N, N-dimethylformamide subsequent trapping with sulfur ylide. Moreover, this broad range substrate scope high functional-group tolerance. This new reaction was successfully utilized in synthesis potent CYP19 aromatase inhibitor...
Total syntheses of three different lamellarins have been accomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole ring. The striking features this synthesis are use PEG-400 as green solvent for reaction and multiple catalytic reactions with excellent overall yield. present route also enables various lamellarin analogues devoid B
Abstract Bei der Entwicklung neuer Wirkstoffe spielen Naturstoffe eine wichtige Rolle. Besondere Bedeutung kommt ihnen auf den Gebieten Antiinfektiva, Krebstherapeutika und Immunsuppressiva zu. Die Zahl natürlich vorkommenden Substanzen ist jedoch begrenzt, wohingegen durch die Kombination von Teilen unterschiedlicher Millionen Naturstoffhybriden mit vielfältigen verschiedenartigen Eigenschaften zugänglich sein sollten. Dieser Ansatz für Leitstrukturen sowohl medizinische als auch...
Adams' catalyst in poly(ethylene glycol) (PEG) (400) has been found to be a superior solvent over the ionic liquids by severalfold promoting hydrogenation of various functional groups. Both and PEG were recycled efficiently 10 runs without loss activity, substrate cross contamination was not observed despite change four times.
A combination of Pd(OAc)2 (5 mol %), PPh3 (10 and Et3B (200 %) promotes the formation allyl phenyl sulfones from allylic alcohols directly with excellent yields under mild conditions. The activation an alcohol group is not necessary which achieved in situ. conjugated dienols also were equally effective for said transformation.
Enantiopure cyclohexane fused tetrahydropyrans have been synthesized using domino Michael-ketalization under organocatalysis.