A5083546619- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Chronic Myeloid Leukemia Treatments
- Chemistry and Chemical Engineering
- Polymer crystallization and properties
- Cyclopropane Reaction Mechanisms
- Microplastics and Plastic Pollution
- Antimicrobial agents and applications
- PI3K/AKT/mTOR signaling in cancer
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Dendrimers and Hyperbranched Polymers
- Ionic liquids properties and applications
- Synthesis and Biological Activity
- Multicomponent Synthesis of Heterocycles
- Carbon dioxide utilization in catalysis
- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- Supramolecular Self-Assembly in Materials
- Catalysis for Biomass Conversion
Agency for Science, Technology and Research
2011-2023
Institute of Chemical and Engineering Sciences
2014-2022
Indian Institute of Chemical Technology
2006-2008
Poly(alkyl)acrylates are a major class of nonbiodegradable polymers which difficult to recycle due an all-carbon backbone. Introducing certain number ester bonds in the backbone via radical ring opening copolymerization acrylates with 2-methylene-1,3 dioxepane (MDO) improves its degradability and may be promising for chemical recycling. The current work examines influence monomer addition profiles on MDO. We improved homogeneity MDO insertion through semibatch approach, was demonstrated by...
Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, constitutively active tyrosine kinase fusion gene responsible for an abnormal proliferation of leukemic stem cells (LSCs). Inhibition BCR-ABL1 activity offers long-term relief to CML patients. However, proportion them, inhibition will become ineffective at treating the disease, and progress blast crisis (BC) with poor prognosis. BC-CML often associated excessive phosphorylated eukaryotic translation initiation...
Adams' catalyst in poly(ethylene glycol) (PEG) (400) has been found to be a superior solvent over the ionic liquids by severalfold promoting hydrogenation of various functional groups. Both and PEG were recycled efficiently 10 runs without loss activity, substrate cross contamination was not observed despite change four times.
Dual stimuliresponsive main-chain degradable star hyperbranched polymers have been synthesized <italic>via</italic> cyclic ketene acetal radical ring-opening and RAFT-based methacrylate copolymerization.
Poly(ε-caprolactone) (PCL) is a widely employed biodegradable polymer synthesized commercially using stannous octoate-mediated ring-opening polymerization (ROP) of ε-caprolactone (ε-CL). It needs to be revisited in alignment with green chemistry principles, such as less hazardous chemical syntheses. We identified and optimized two emerging methods—Route A: acid-catalyzed ROP ε-CL hydrogen chloride (HCl) diethyl ether; Route B: free-radical cyclic ketene acetal (CKA) monomer,...
Abstract In this article, a Lewis acid mediated 1,4‐addition/formal [3+2] cycloaddition reaction engaging functionalized β‐carboline and 1,4‐benzoquinone has been demonstrated. Application of developed technology facilitated the construction challenging C‐9′–C‐15 quaternary center linkage in dimeric indole alkaloid, haplophytine, enabled preparation an advanced key intermediate en route to total synthesis historical natural product.
ABSTRACT Radical ring‐opening polymerization (rROP) reaction of cyclic ketene acetals (CKA) is an interesting route to biodegradable polymers. Contrary their tremendous potential, fundamental understanding kinetics and thermodynamics still limited. We present experimental theoretical investigations for rROP reactions CKA systematically elucidate the effects monomer ring sizes on homopolymerization. aim provide insights structural‐reactivity relationship by studying forward propagation key...
The design, synthesis and characterization of a new class peptide nanotubes, self-assembled from cyclic homo- hetero-β-peptides based on cis-furanoid sugar amino acid β-hGly residues are described; these results represent the expansion conformational pool cis β-sugar acids in design nanotubes.
Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types cancers. Inhibition Mnk prevents phosphorylation, making them potential therapeutic targets for cancer. Recently, we have designed synthesized a series novel imidazopyridine imidazopyrazine derivatives that inhibit Mnk1/2 kinases potency in nanomolar to micromolar range. In...
An efficient and practical total synthesis of marine cyclic tetrapeptide, natural product azumamide E (1) is achieved via high-yielding reactions. The strategy also allowed us to synthesize the E-SAA (sugar amino acid) analogue (2), whose solution-phase NMR biological activity studies were carried out.
Degradable analogues of polystyrene are synthesized via radical ring-opening (co)polymerization (rROP) between styrene and two cyclic ketene acetals, namely 2-methylene-1,3-dioxepane (MDO) 5,6-benzo-2-methylene-1,3-dioxepane (BMDO). This approach periodically inserts ester bonds throughout the main chain polystyrene, imparting a degradation pathway hydrolysis. We discuss historical record this approach, with careful attention paid to conflicting findings previously reported. have found...
Short homo-oligomers of a new building block, cis-β2,3-furanoid sugar aminoxy acid, are designed, characterized, and found to exhibit rigid ribbon-like secondary structures composed 5/7 bifurcated intramolecular hydrogen bonds.
Abstract The present work systematically investigates the hydrolysis mechanism of cyclic ketene acetal (CKA) monomers in detail and explores polymerization water under organic solvent‐free surfactant‐free conditions. To understand effect CKA structure on hydrolysis, ring size is varied from 5–8‐membered rings experiments are performed. In all cases, yields monoacetylated diol products. Deuterium 17 O‐isotopic labeled carried out for 5‐ 7‐membered‐(2‐methylene‐1,3‐dioxepane, MDO) CKAs to...
Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust straightforward route to main-chain polymeric in the sub-30 nm size range.
Abstract The marketed BCR-ABL tyrosine kinase inhibitor (TKI), imatinib (Gleevec™) is a very successful targeted anti-cancer therapy. It has revolutionized the treatment of early stage or chronic phase (CP) myeloid leukemia (CML). Unfortunately, proportion CP patients experience suboptimal responses to TKIs, and progress blast crisis (BC) CML with poor survival rate. A potential cause resistance TKI elevated level phosphorylated eukaryotic initiation factor 4E (eIF4E), which been found be...