A5027506002- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Microbial Natural Products and Biosynthesis
- Computational Drug Discovery Methods
- Advanced Synthetic Organic Chemistry
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Organic Chemistry Cycloaddition Reactions
- Carbohydrate Chemistry and Synthesis
- Alkaloids: synthesis and pharmacology
- Porphyrin and Phthalocyanine Chemistry
- Marine Toxins and Detection Methods
- Analytical Chemistry and Sensors
- Bioactive Natural Diterpenoids Research
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Chemical Synthesis and Reactions
- Spectroscopy and Chemometric Analyses
- Water Quality Monitoring and Analysis
- Lysosomal Storage Disorders Research
- Cancer Treatment and Pharmacology
Nihon University
2014-2025
Foundation for Advancement of International Science
2025
Hokkaido University
1998-2024
St. Luke's International Hospital
2024
Keio University
1992-2024
Meijo University
2024
Yokohama University of Pharmacy
2024
Kyushu University
2024
Thermo Fisher Scientific (Japan)
2023
Waseda University
2004-2021
A problem solved: Haplophytine (1) yields to total synthesis through a convergent strategy employing modern synthetic methods. Key steps include hypervalent iodine mediated oxidative coupling, semi-pinacol type skeletal rearrangement, Suzuki–Miyaura and radical cyclisation. Detailed facts of importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The...
Samples from the carbonaceous asteroid (162173) Ryugu provide information on chemical evolution of organic molecules in early solar system. Here we show element partitioning major component ions by sequential extractions salts, carbonates, and phyllosilicate-bearing fractions to reveal primordial brine composition primitive asteroid. Sodium is dominant electrolyte salt fraction extract. Anions NH4+ are more abundant than carbonate phyllosilicate fractions, with molar concentrations order...
Abstract For see ChemInform in Full Text.
As the largest secondary metabolite to be discovered as of yet, polyether marine neurotoxin maitotoxin constitutes a major structural and synthetic challenge. After its originally proposed structure (1) had been questioned on basis biosynthetic considerations, we provided computational experimental support for 1. In an effort provide stronger evidence molecular architecture maitotoxin, GHIJKLMNO ring system 3 was synthesized. The 13C NMR chemical shifts matched closely those corresponding...
Abstract This paper reports on the evaluation of diamagnetic energy using loops in JT-60SA, largest operating tokamak world, and revisits physics behind poloidal beta (βp) internal inductance (li). During first operation phase measurements were utilized assessing parameters related to plasma equilibrium, such as stored energy, βp li. The evaluated is above 200 kJ with 1 MJ electron cyclotron heating, we observed li rise from around unity 2 during current ramp- down phase. successfully...
Patients with severe liver dysfunction present significant perioperative challenges, including the risk of postoperative cognitive (POCD) and hepatic encephalopathy (HE), after general anesthesia. While avoiding anesthesia deep sedation is crucial for early recovery in this patient population, neuraxial block techniques are often contraindicated due to coagulation disorders. A 73-year-old male (190 cm tall, weighing 77 kg) Child-Pugh C cirrhosis (score 10), coagulopathy (platelets 90,000/μL,...
Epidural analgesia is typically avoided in patients with portal hypertension due to multiple risk factors: engorgement of epidural venous plexuses, platelet dysfunction despite normal counts, and potential postoperative coagulopathy following liver surgery. These risks persist even when preoperative coagulation parameters appear normal. While peripheral nerve blocks are increasingly utilized for minimally invasive laparoscopic procedures, intertransverse process block (ITPB) catheter...
Abstract In the control of large superconducting tokamaks, particularly for devices like DEMO reactors, where no stabilizing plates or in-vessel coils due to existence tritium blankets, position, shape, and current plasmas must be controlled solely with coils, which we developed novel schemes [S. Inoue et al., Nuclear Fusion 61, 096009 (2021)]; an adaptive voltage allocation (AVA) scheme automatically allocates power supply voltages plasma position/shape control, a robust last closed flux...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular design and chemical synthesis of potent enediynes. 1. Dynemicin model systems equipped with N-tethered triggering devicesK. C. Nicolaou, P. Maligres, T. Suzuki, S. V. Wendeborn, W. M. Dai, R. K. ChadhaCite this: J. Am. Chem. Soc. 1992, 114, 23, 8890–8907Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November...
The MIDA touch: A concise and highly convergent protecting-group-free total synthesis of (−)-myxalamide involves a stereoselective vinylogous Mukaiyama aldol reaction vinylketene silyl N,O-acetal, together with one-pot Stille/Suzuki–Miyaura cross-coupling using Burke's N-methyliminodiacetic acid (MIDA) boronate to connect left- right-hand fragments the molecule (see scheme).
(+)-Iso-A82775C is a proposed biosynthetic precursor of the chloropupukeananin family and an important intermediate for related natural products. The first enantioselective total synthesis (+)-iso-A82775C (18 steps, 2.2% overall yield) toward eventual biomimetic described. key steps are (1) Diels–Alder reaction 4-bromo-3-hydroxy-2-pyrone with methyl 2-chloroacrylate using cinchonine as organocatalyst (2) anti-selective Cu-mediated SN2′ to afford axially chiral vinylallene moiety.
The electrochemically reversible photoluminescence of sulforhodamine B (SRB) anions is demonstrated based on the redox Fe in a metallo-supramolecular polymer.
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from fungal culture broth of Penicillium herquei. The structures these compounds determined by interpretation spectroscopic data (1D/2D NMR, MS, IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), herqueinone/isoherqueinone (7/7a), also obtained. tested for anti-hepatitis C virus (HCV) activity, peniciherquamide (3) was found to...
Remimazolam, an ultra-short-acting benzodiazepine, has been used for procedural sedation in the United States. We conducted investigator-initiated clinical trial to determine appropriate dose of remimazolam required during gastrointestinal endoscopy Japanese subjects.In this single-center, open-label, uncontrolled, phase II trial, a three-stage cohort investigated initial and additional doses endoscopy. This study was designed with advice from Pharmaceuticals Medical Devices Agency. The were...
Sequences of the 16S rRNA gene were determined for three strains aerobic bacteriochlorophyll a-containing bacteria isolated from soil. The sequences two (NS89Tand NS102) identical approximately 1500 nucleotides. Phylogenetic analysis revealed that belonged to α-1 subclass Proteobacteria, constituting one line descent. are comparatively related Roseococcus thiosulfatophilus, which is an bacterium. sequence similarity and DNA-DNA relatedness allow proposal new genera, Craurococcus gen. nov....
A concise synthesis of a highly functionalized chloropupukeananin (1) skeleton via reverse electron-demand Diels-Alder reaction and intramolecular carbonyl-ene sequence based on our proposed biosynthetic pathway is described.
Nozaki-Hiyama reactions are powerful Cr(II)-mediated C--C bond-forming conducted under mild conditions that show excellent compatibility with various functional groups. Therefore, have been utilized for many total syntheses of complex natural products, but at least two equivalents Cr(II) salt required to complete the reaction because is a one-electron donor. In 1996, however, quantity salts was successfully reduced by catalytic redox system reported Fürstner and Shi. Since report Fürstner,...
Two key reaction types were used for the total synthesis of antibiotic agent (+)-TMC-151C: vinylogous Mukaiyama aldol and silicon-tethered ring-closing metathesis (RCM; see scheme). This strategy should provide efficient access to a range related natural polyketides containing pent-2-ene-1,5-diol units. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
Intelligent design: The total synthesis of the cytotoxic (-)-FR182877 relies on 1) tandem Diels-Alder reactions to close rings A-D (see scheme), 2) a palladium-mediated 7-exo-trig reaction, and 3) an iridium-mediated isomerization followed by epimerization stereoselective reduction.
Abstract In this article, a Lewis acid mediated 1,4‐addition/formal [3+2] cycloaddition reaction engaging functionalized β‐carboline and 1,4‐benzoquinone has been demonstrated. Application of developed technology facilitated the construction challenging C‐9′–C‐15 quaternary center linkage in dimeric indole alkaloid, haplophytine, enabled preparation an advanced key intermediate en route to total synthesis historical natural product.
The biomimetic synthesis of the advanced model compound chloropupukeananin has been achieved. present features an unexpected enantiomer-differentiating Diels–Alder/carbonyl-ene cascade under high-pressure conditions and a base-promoted migration salicyl group.
The first synthesis of decahydrofluorene core 4 pyrrocidines was accomplished. cis,trans-fused tricyclic ring system stereoselectively constructed via Diels–Alder reaction using two Danishefsky dienes.