José C. Aponte
A5040697300- Astro and Planetary Science
- Isotope Analysis in Ecology
- Origins and Evolution of Life
- Mass Spectrometry Techniques and Applications
- Planetary Science and Exploration
- Analytical Chemistry and Chromatography
- Astrophysics and Star Formation Studies
- Cassava research and cyanide
- Geology and Paleoclimatology Research
- Asymmetric Synthesis and Catalysis
- Trypanosoma species research and implications
- Viral Infections and Vectors
- High-pressure geophysics and materials
- Space Exploration and Technology
- Mosquito-borne diseases and control
- Metabolomics and Mass Spectrometry Studies
- Synthesis and Biological Evaluation
- Traditional and Medicinal Uses of Annonaceae
- Smoking Behavior and Cessation
- Nuclear Physics and Applications
- Marine and environmental studies
- History and advancements in chemistry
- Phytochemical compounds biological activities
- Fluid Dynamics Simulations and Interactions
- Scientific Research and Technology
Goddard Space Flight Center
2016-2025
Catholic University of America
2015-2024
University of Puerto Rico at Río Piedras
2024
University of America
2015-2022
Centers for Disease Control and Prevention
2022
Center for Surveillance, Epidemiology, and Laboratory Services
2022
University of Córdoba
2019
University of Louisville
2008-2018
Universidad Bicentenaria de Aragua
2017
Brown University
2011-2015
Abstract During its approach to asteroid (101955) Bennu, NASA’s Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) spacecraft surveyed Bennu’s immediate environment, photometric properties, rotation state. Discovery of a dusty natural satellite, or unexpected characteristics would have had consequences for the mission’s safety observation strategy. Here we show that observations during this period were highly sensitive satellites (sub-meter...
Electronic cigarettes (e-cigarettes), also called vapes, e-hookas, vape pens, tank systems, mods, and electronic nicotine delivery systems (ENDS), are devices that produce an aerosol by heating a liquid typically containing nicotine, flavorings, other additives; users inhale this into their lungs (1). E-cigarettes can be used to deliver tetrahydrocannabinol (THC), the principal psychoactive component of cannabis Use e-cigarettes is commonly vaping. Lung injury associated with e-cigarette...
The Hayabusa2 spacecraft collected samples from the surface of carbonaceous near-Earth asteroid (162173) Ryugu and brought them to Earth. were expected contain organic molecules, which record processes that occurred in early Solar System. We analyzed molecules extracted samples. identified a variety containing atoms CHNOS, formed by methylation, hydration, hydroxylation, sulfurization reactions. Amino acids, aliphatic amines, carboxylic polycyclic aromatic hydrocarbons, nitrogen-heterocyclic...
Organic matter in meteorites reveals clues about early Solar System chemistry and the origin of molecules important to life, but terrestrial exposure complicates interpretation. Samples returned from B-type asteroid Bennu by Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer mission enabled us study pristine carbonaceous astromaterial without uncontrolled Earth's biosphere. Here we show that samples are volatile rich, with more carbon, nitrogen ammonia than...
CDC, the Food and Drug Administration, state local health departments, other public clinical stakeholders are investigating a national outbreak of electronic-cigarette (e-cigarette), or vaping, product use-associated lung injury (EVALI) (1). As October 22, 2019, 49 states, District Columbia (DC), U.S. Virgin Islands have reported 1,604 cases EVALI to including 34 (2.1%) EVALI-associated deaths in 24 states. Based on data collected as 15, this report updates patient characteristics substances...
Samples from the carbonaceous asteroid (162173) Ryugu provide information on chemical evolution of organic molecules in early solar system. Here we show element partitioning major component ions by sequential extractions salts, carbonates, and phyllosilicate-bearing fractions to reveal primordial brine composition primitive asteroid. Sodium is dominant electrolyte salt fraction extract. Anions NH4+ are more abundant than carbonate phyllosilicate fractions, with molar concentrations order...
Polycyclic aromatic hydrocarbons (PAHs) contain ≲20% of the carbon in interstellar medium. They are potentially produced circumstellar environments (at temperatures ≳1000 kelvin), by reactions within cold (~10 kelvin) clouds, or processing carbon-rich dust grains. We report isotopic properties PAHs extracted from samples asteroid Ryugu and meteorite Murchison. The doubly-13C substituted compositions (Δ2×13C values) naphthalene, fluoranthene, pyrene 9 to 51‰ higher than values expected for a...
Synthesis of a cytotoxic dihydrochalcone, first isolated from traditional Amazonian medicinal plant Iryanthera juruensis Warb (Myristicaceae), followed by comprehensive SAR analysis saturated and unsaturated chalcone synthetic intermediates, led to the identification analogues with selective significant in vitro anti-Trypanosoma cruzi activity. Further studies were undertaken synthesis 21 new chalcones containing two allyloxy moieties that resulted discovery 2′,4′-diallyloxy-6′-methoxy...
Abstract The Asuka (A)‐12236 meteorite has recently been classified as a CM carbonaceous chondrite of petrologic type 3.0/2.9 and is among the most primitive meteorites studied to date. Here, we report concentrations, relative distributions, enantiomeric ratios amino acids in water extracts A‐12236 another Elephant Moraine (EET) 96029 (CM2.7) determined by ultra‐high‐performance liquid chromatography time‐of‐flight mass spectrometry. EET was highly depleted dominated glycine, while wide...
Abstract The abundances, distributions, enantiomeric ratios, and carbon isotopic compositions of amino acids in two fragments the Aguas Zarcas CM 2 type carbonaceous chondrite fall a fragment Murchison meteorite were determined via liquid chromatography time‐of‐flight mass spectrometry gas isotope ratio spectrometry. A suite two‐ to six‐carbon aliphatic primary was identified meteorites with abundances ranging from ~0.1 158 nmol/g. high relative α‐amino found these are consistent...
Abstract Evaluating the molecular distribution of organic compounds in pristine extraterrestrial materials is cornerstone to understanding abiotic synthesis organics and allows us better understand diversity available during formation our solar system before origins life on Earth. In this work, we identify multiple solvent extracts asteroid Ryugu samples A0106 C0107 Orgueil meteorite using two-dimensional gas chromatography time-of-flight high resolution mass spectrometry (GC×GC–HRMS). Our...
Abstract We report primordial aqueous alteration signatures in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu by Hayabusa2 spacecraft of JAXA. Newly identified low-molecular-weight hydroxy acids (HO-R-COOH) and dicarboxylic (HOOC-R-COOH), such as glycolic acid, lactic glyceric oxalic succinic are predominant samples two touchdown locations at Ryugu. The quantitative qualitative profiles for hydrophilic between sampling shows similar trends within order ppb...
Abstract We analyzed 12 Apollo 17 samples through the Next Generation Sample Analysis (ANGSA) program to determine abundances of a variety compound classes, including amino acids, aldehydes, ketones, amines, carboxylic and cyanide‐releasing species. Analyzed included portions double drive tube 73001/73002, bottom half which (73001) was hermetically sealed under lunar vacuum, as well regolith from three different illumination environments that had been curated frozen for ∼50 years. Consistent...
The Caribbean area of Colombia has been severely affected by a Chikungunya virus (CHIKV) outbreak since 2014.The study was carried out on 100 patients during fever from August to September 2014 in two small rural villages the northern Colombia. molecular assays performed reverse transcription polymerase chain reaction (RT-PCR) acute patient sera were collected within one five days appearance symptoms. Sequence analyses based phylogenetic genes NS1 and E2. For serological assays, 49 (49%) at...
Glycine and methylamine are meteoritic water-soluble organic compounds that provide insights into the processes occurred before, during, after formation of Solar System. Both glycine many their potential synthetic precursors have been studied in astrophysical environments via observations, laboratory experiments, modeling. In spite these studies, mechanisms for leading to occurrence meteorites remain poorly understood. Typical 13C-isotopic values (δ13C) 13C-enriched relative terrestrial...