To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in multicenter, randomized, double-blind, investigator-initiated phase III controlled trial.

<b><i>Introduction:</i></b> We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation patients undergoing colonoscopies. <b><i>Methods:</i></b> This multicenter, double-blind, placebo-controlled, phase III included who underwent colonoscopy under with (initial dose: 3 mg; additional 1 mg) or normal saline (placebo). The primary endpoint of the study successful rate during colonoscopy, defined as...

In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra-short-acting benzodiazepine, may reduce recovery time after endoscopic procedures. This study was secondary analysis of the investigator-initiated trial, which investigated efficacy and safety remimazolam in gastrointestinal endoscopy (REM-IICT JP01). Remimazolam administered during upper endoscopy. Patients were divided into two groups: 45...

ABSTRACT Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy Japan as a sub‐analysis data from an investigator‐initiated clinical trial remimazolam. Methods Results Patients two groups were matched using propensity score matching. We evaluated time end until discharge, procedure awakening, adverse events. Overall, 36 participants population who underwent 199 patients with during same period included this study. Following matching, 34 both...

GH induces preantral follicle growth and differentiation with oocyte maturation. However, the effects of on ovarian steroidogenesis mechanisms underlying its have yet to be elucidated. In this study, we investigated actions by rat granulosa cells isolated from early antral follicles focusing bone morphogenetic protein (BMP) system. We found that suppressed FSH-induced estradiol production reduction in aromatase expression and, contrast, increased progesterone level induction steroidogenic...

Remimazolam, an ultra-short-acting benzodiazepine, has been used for procedural sedation in the United States. We conducted investigator-initiated clinical trial to determine appropriate dose of remimazolam required during gastrointestinal endoscopy Japanese subjects.In this single-center, open-label, uncontrolled, phase II trial, a three-stage cohort investigated initial and additional doses endoscopy. This study was designed with advice from Pharmaceuticals Medical Devices Agency. The were...

To compare the efficacy and safety of sedation with midazolam remimazolam for colorectal endoscopy.

Leptin, which is the product of obese gene, believed to play important roles in pubertal development and reproductive function females. In a study using adult male rats, it was found that leptin stimulated secretion gonadotropin from pituitary dose-related manner. However, there has been no such female rats.To investigate effects on production LH FSH primary cultured cells.In this study, we determined body weight, serum concentration estradiol (E(2)) Wistar rats at 3, 5, 6, 7, 9 11 weeks...

Facilitative glucose transporter-1 (GLUT1) is abundant in trophoblast cells and responsible for transport the placenta. However, change GLUT expression human placenta upon differentiation remains to be clarified. Therefore, we first examined localization of GLUT1 GLUT3 using first-trimester chorionic villi. We found that were mainly localized syncytiotrophoblast cytotrophoblast respectively. analyzed whether placental changes during a choriocarcinoma (BeWo) cell line which known show...

Leptin is an adipocyte-derived hormone, which the product of obese gene and it thought to play important roles in pubertal development maintenance reproductive function female. In a study using adult male or female rats, was found that leptin stimulated secretion gonadotropin directly from pituitary dose-related manner. However, there no juvenile rats before puberty.In this study, we cultured cells 4-, 6- 8-week-old Wistar with (0-10(-7)mol/l) gonadotropin-releasing hormone (GnRH) (0 10(-8)...

Facilitative glucose transporter-1 (GLUT1) is expressed abundantly and has an important role in transfer placentas. However, little known about the regulation of GLUT1 expression placental cells. We studied changes levels relation to concentration vitro vivo. In experiments, dispersed mouse cells were incubated under control (5.5 mM) moderately high (22 concentrations, 2-deoxyglucose uptake into was on days 1-5 culture. After 4 incubation both conditions, mRNA proten examined by Northern...

Abstract Background Vonoprazan‐based Helicobacter pylori ( H. ) treatment is highly effective in eradicating the target bacteria; however, its post‐1‐year impact on gut microbiota unknown. This study evaluated of vonoprazan‐based therapy 1‐year post‐therapy and investigated relationship between body weight changes perturbations. Materials Methods Between March May 2019, 43 patients with infections received either vonoprazan/amoxicillin (VA) or vonoprazan/amoxicillin/clarithromycin (VAC)...

Abstract BACKGROUND Safe and appropriate harvesting of the donor scalp vessel is first key procedure in any type bypass surgery. OBJECTIVE To use so-called bipolar cutting method to harvest arteries, which arteries are skeletonized with cautery. The surgical preparation equipment described. results histological assessment presented. METHODS generator was set at 50 Malis units coagulation mode. Under microscope, surrounding tissue artery divided coagulated forceps. completely provide adequate...

BACKGROUND:Infective endocarditis (IE) involving the mitral valve can but rarely lead to complete atrioventricular block (CAVB). CASE REPORT:A 74-year-old man with a history of infective caused by Streptococcus gordonii (S. gordonii) presented our emergency room fever and loss appetite, which had lasted for 5 days. On admission, results serologic tests pointed severe infection. Electrocardiography showed normal sinus rhythm first-degree incomplete right bundle branch block, transthoracic...

Summary This study was carried out to investigate the effect of compression induced by complete dentures on function nerves underlying dentures. The influence nerve analysed using current perception threshold (CPT) in 33 denture wearers aged 50–80 at Nihon University School Dentistry (Matsudo, Japan). Based age range group, dentate subjects were selected as a control. Because group characteristics (such subject age, gender, body mass index) and oral mucosal thickness not matched, multiple...

The efficacy of transnasal endoscopy using an ultrathin endoscope has been reported in several studies. However, few studies regarding peroral with endoscopes high resolution have reported. This study investigates the pain alleviation endoscope.Patients a history conventional, normal-diameter scope no sedation who underwent esophagogastroduodenoscopy (EGD) thin between April-July 2022 were included this study. After procedure, patients completed questionnaire evaluating during examination...

Abstract The regulation of mouse placental lactogen (mPL)-I and mPL-II secretion by activin inhibin the expression subunit mRNAs in decidua were examined. Activin-A at a concentration 10 nm/l significantly inhibited cells from days 9 12 pregnancy. However, activin-A did not affect mPL-I 7 pregnancy nor day By contrast, activated These effects on dose-dependent. Follistatin, which binds to blocks its bioactivity, completely eliminated inhibitory effect secretion. Incubation with resulted...

Abstract Colonoscopies are widely available, but there cases where insertion can be difficult, even for experienced endoscopists. EC-760XP/L, a new ultrasmall-diameter long scope, may useful in such cases. This single-center retrospective study included 39 colonoscope was difficult when previously conducted by an endoscopist. The primary outcome the cecal intubation time using EC-760XP/L compared to previous examination with standard scope. secondary outcomes were cecum rate, intestinal...

Chronic constipation is a significant factor in poor bowel preparation for colonoscopy. Macrogol 4000 plus electrolytes (Movicol, EA Pharma, Tokyo, Japan), containing polyethylene glycol (PEG) and electrolytes, have been used recently to treat patients with constipation. However, prospective studies on the use of macrogol cleansing colonoscopy are lacking. This study aimed investigate efficacy safety addition PEG administered chronic constipation.This single-center, single-arm enrolled who...