Abstract Background In order to reduce fluoroscope usage in endovascular surgery, there is a need develop autonomous catheter insertion systems. Methods We propose system for tracking the position and speed of using magnetic motion capture sensor provide feedback catheter‐driving mechanism, perform major vasculature. Catheter control path reconstruction experiments were performed with inside silicone model vasculature simulate surgery. Results The controlled speeds 6.14 mm/s reproduced...

The causative agents of recurrent Escherichia coli bacteremia can be genetically identical or discordant, but the differences between them remain unclear. This study aimed to explore these differences, with regard their clinical and microbiological features. Patients were recruited from a Japanese tertiary teaching hospital based on blood culture data incidence E. bacteremia. We compared patients' characteristics two groups (those discordant bacteremia) divided by result enterobacterial...

Understanding adaptation involves establishing connections between selective agents and beneficial population responses. However, relatively little attention has been paid to seasonal adaptation, in part, because it requires complex integrative knowledge about seasonally fluctuating environmental factors, the effects of variable phenology on exposure those evidence for temporal specialization. In European corn borer moth, Ostrinia nubilalis, sympatric pheromone strains exploit same host...

Although epidemiological surveillance of COVID-19 has been gradually downgraded globally, the transmission continues. It is critical to quantify dynamics using multiple datasets including wastewater virus concentration data. Herein, we propose a comprehensive method for estimating effective reproduction number The data, which were collected twice week, analyzed daily incidence data obtained from Takamatsu, Japan between January 2022 and September 2022. We estimated shedding load distribution...

Background Mobility data are crucial for understanding the dynamics of coronavirus disease 2019 (COVID-19), but consistency usefulness these over time has been questioned. The present study aimed to reveal relationship between transmissibility COVID-19 in Tokyo, Osaka, and Aichi prefectures daily night-time population metropolitan areas belonging each prefecture. Methods In Japan, de facto estimated from GPS-based location mobile phone users is regularly monitored by Ministry Health, Labor,...

The COVID-19 pandemic had a low impact on Japan in 2020, but the size of epidemic increased considerably there 2021. This study made statistical analysis life expectancy changes up to end 2021 Japan.We aimed estimate from 2019 associated with pandemic. To do so, we decomposed 2020-2021 into age-specific and cause death-specific contributions.We used absolute number deaths by age prefecture calculate 2019-21 at both national prefectural levels, also examined correlation between gap annual...

The cross-correlation search has been previously applied to map the gravitational wave (GW) stochastic background in sky and also target GW from rotating neutron stars/pulsars. Here we investigate how method can be used a small region spanning at most few pixels, where pixel is determined by diffraction limit which depends on (i) baseline joining pair of detectors (ii) detector bandwidth. as one promising targets, consider Virgo cluster---a ``hot spot'' pixels---which could contain,...

Neuroferritinopathy is a rare, adult-onset, dominantly inherited movement disorder caused by mutations in the ferritin gene. A light-chain variant related to neuroferritinopathy, which alanine 96 replaced with threonine (A96T), was expressed Escherichia coli, purified, and characterized. The circular dichroism, analytical ultracentrifugation, small-angle X-ray scattering studies have shown that both subunit structure assembly of A96T are same as those wild-type human light chain (HuFTL)....

Abstract Demographic analyses enable the evaluation of impact COVID-19 on life expectancy. We evaluated relationship between expectancy change from 2020–21 and 2021–22 epidemic size at prefectural level in Japan. also conducted age- cause-specific decomposition change. Trends span equality 2000–22 were national level. Prefectural analysis annual per-population cases, person-days intensive care, reported deaths showed no significant correlations, unlike our 2020–21. However, revealed...

1. Cl‐ channels in the basolateral membrane of non‐stimulated parietal cells isolated rabbit gastric glands were studied by patch‐clamp and noise analysis techniques. 2. Voltage‐independent whole‐cell currents recorded from equilibrated with Cl(‐)‐containing solutions. Upon reducing concentration bathing solution, current‐voltage curve was rapidly shifted to right. The reversal potential changed according changes equilibrium for Cl‐. 3. A channel blocker,...

Abstract Background To date, no quantitative analysis has been developed to evaluate catheter performance inside the vascular lumen. Methods An evaluation system for endovascular tools was built with a polyurethane elastomer model polariscope and driving system. This robotic reproduced insertion trajectory model, using surgical three prototypes used motion capture on surgery simulation. Birefringence is produced by photo‐elastic characteristics of when material submitted external stress. The...

Abstract Background Although Escherichia coli is the most frequently isolated microorganism in acute biliary tract infections with bacteremia, data regarding its virulence are limited. Results Information on cases of bacteremia infection a retrospective study was collected from 2013 to 2015 at tertiary care hospital Japan. Factors related severity were investigated, including patient background, phylogenetic typing, and factors E. , such as adhesion, invasion, toxins, iron acquisition. In...

Endovascular intervention using interventional radiology (IVR) is most commonly used in cerebralvascular treatment. Medical imaging such as digital subtraction angiography (DSA) and vascular mapping make vasculature catheters easier to read from fluoroscopy during endovascular intervention. We propose simulating IVR augmented reality, reproducing fluoroscopic images a patient-specific blood vessel model without X-ray imaging. The advantages of the human lumen with 13 μm resolution include 1)...

Vibrio fluvialis is a foodborne pathogen known to cause cholera-like gastroenteritis syndrome. Here we report the first case of V. liver abscess and bacteremia presumed be from sashimi, Japanese raw seafood delicacy. We also provide literature review reported cases extra-intestinal diseases including bacteremia.

Mycobacterium haemophilum is a nontuberculous mycobacteria (NTM) with predilection for skin and soft tissue infection (SSTI) in the immunocompromised host. We report case of disseminated M initially presenting as nonresolving subacute cellulitis bilateral lower extremities. Genetic sequencing was used final identification, while commercially available polymerase chain reaction test returned false-positive result intracellulare. Consequently, we highlight importance major differential...

An investigation quantifying the fluctuation of finger pulse and detecting situation that driver's mental workload is extremely high was carried out in a driving simulator. The Lyapnov exponent, which one state variables pulse, evaluated terms accuracy to detect hazardous situation. exponent will fluctuate according measuring condition or physical driver. But, normalized meaning ratio relative during ordinary situation, same range between 120 [%] 180 [%], when high. threshold dividing with...

Quorum sensing is known to regulate bacterial virulence, and the accessory gene regulator ( agr ) loci one of genetic responsible for its regulation. Recent reports examining Clostridioides difficile show that two loci, agr1 agr2, toxin production, but diversity their epidemiology unknown. In our study, in silico analysis was performed research , C. isolates from clinical samples underwent multilocus sequence typing (MLST) PCR loci. To reveal distribution among different strains,...

Magnetic motion capture sensors (MMCS) are not commonly used for robot control due to the need complex, resource-consuming calibration correct error introduced by magnetic sensor. We propose avoiding such using a rule-based controller that only uses spatial coordinates from This sparse look-up table of and actions conducted reacts presence sensor near reference points. The method was applied manipulate robotic camera track catheter-shaped inside vessels silicone models. A second evaluation...

In this paper, we propose a novel method to develop biomimetic models using polyurethane elastomer, which has high photoelastic coefficient, and analyze stress states on the model by effect. By method, condition vascular wall is clearly visualized fringe as rainbow-colored pattern, can be quantitatively measured from that pattern. Ideally, retardation path length of transmitted light through should observed for analysis. Our capability observe these two parameters simultaneously. Retardation...

Hepatitis E virus (HEV) is a common cause of acute hepatitis. Four major genotypes HEV have been studied, with genotype 4 being the predominant across Asia. We herein describe case 50-year-old man history human immunodeficiency (HIV) infection who was admitted transaminitis. Serum anti-HEV-IgA and HEV-RNA were detected at time presentation further testing revealed 4. To best our knowledge, this represents first clinical report symptomatic in an HIV-positive patient Japan.

In order to reduce fluoroscope usage in endovascular surgery there is a need develop autonomous catheter insertion systems. We propose system for tracking the position of using magnetic motion capture sensor provide feedback driving mechanism perform major vasculature. Catheter path reconstruction experiments were performed with inside silicone model vasculature simulate surgery. As result reproduced blood vessel phantom less than 7 mm error. found that error depends on model's cross-section...