A5046522736- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Liver Diseases and Immunity
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
Kanto Central Hospital
2021-2025
The University of Tokyo
2015-2024
University of Tokyo Hospital
2014-2024
Jikei University School of Medicine
1993-2024
Nippon Soken (Japan)
2024
The Japanese Society of Gastroenterological Surgery
2016-2023
The Jikei University Hospital
2013-2022
Showa University
2020-2021
Iwate Medical University
2020-2021
Tokyo City University
2018-2020
OBJECTIVES: Radiofrequency ablation (RFA) is widely performed for hepatocellular carcinoma (HCC). However, there has been no report on 10-year outcome of RFA. The objective this study was to a consecutive case series at tertiary referral center. METHODS: We 2,982 RFA treatments 1,170 primary HCC patients and analyzed collected database. RESULTS: Final computed tomography images showed complete tumor in 2,964 (99.4%) the patients. With median follow-up 38.2 months, 5- survival rates were...
Obesity defined by body mass index (BMI) significantly increases the risk of hepatocellular carcinoma (HCC). In contrast, not only obesity but also underweight is associated with poor prognosis in patients HCC. Differences composition rather than BMI were suggested to be true determinants prognosis. However, this hypothesis has been demonstrated conclusively.We measured skeletal muscle (SMI), mean attenuation (MA), visceral adipose tissue index, subcutaneous and area ratios (VSR) via...
Liver steatosis, which involves accumulation of intracytoplasmic lipid droplets, is characteristic hepatitis C virus (HCV) infection. By use an in vivo transgenic murine model, we demonstrate that hepatic overexpression HCV core protein interferes with the assembly and secretion triglyceride-rich very low density lipoproteins (VLDL). Core expression led to reduction microsomal triglyceride transfer (MTP) activity particle size nascent VLDL without affecting MTP disulfide isomerase. Hepatic...
All-oral combinations of direct-acting antivirals may improve efficacy and safety outcomes for patients with hepatitis C virus (HCV) infection, particularly those who are poor candidates current interferon/ribavirin-based regimens. In this open-label, phase 3 study, 135 interferon-ineligible/intolerant 87 nonresponder chronic HCV genotype 1b infection were enrolled at 24 centers in Japan. Patients received daclatasvir 60 mg once daily plus asunaprevir 100 twice weeks. The primary endpoint...
Nonalcoholic steatohepatitis (NASH) can progress to hepatocellular carcinoma (HCC). We aimed characterize the clinical features of NASH patients with HCC.In a cross-sectional multicenter study in Japan, we examined 87 (median age, 72 years; 62% male) histologically proven who developed HCC. The data were collected at time HCC was diagnosed.Obesity (body mass index ≥25 kg/m(2)), diabetes, dyslipidemia, and hypertension present 54 (62%), 51 (59%), 24 (28%), 47 (55%) patients, respectively. In...
Abstract BACKGROUND: Despite significant advances in the treatment of intrahepatic lesions, prognosis for patients with hepatocellular carcinoma (HCC) who have extrahepatic metastasis remains poor. The objective this study was to further elucidate clinical course and prognostic determinants disease. METHODS: In total, 342 had HCC were enrolled. metastases diagnosed at initial presentation 28 during follow‐up remaining patients. authors analyzed features, prognoses, treatments established a...
Inflammation-based prognostic scores including the Glasgow Prognostic Score (GPS), neutrophil to lymphocyte ratio (NLR), and Nutritional Index (PNI) are associated with survival in patients hepatocellular carcinoma (HCC). The aim of this study was investigate value these inflammation-based HCC. In total, 150 newly diagnosed HCC were prospectively evaluated. Patients divided according GPS, modified NLR, platelet (PLR), (PI), PNI. area under receiver operating characteristics curve (AUC)...