A5087225064- Hearing, Cochlea, Tinnitus, Genetics
- Wastewater Treatment and Nitrogen Removal
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Liver Disease Diagnosis and Treatment
- Porphyrin and Phthalocyanine Chemistry
- Natural product bioactivities and synthesis
- Phosphorus and nutrient management
- Constructed Wetlands for Wastewater Treatment
- Ear Surgery and Otitis Media
- Geotechnical Engineering and Soil Stabilization
- Pancreatic and Hepatic Oncology Research
- Phytochemical Studies and Bioactivities
- Epigenetics and DNA Methylation
- Chemical Synthesis and Characterization
- Hepatitis C virus research
- Radioactive element chemistry and processing
- Catalytic Processes in Materials Science
- Structural Analysis and Optimization
- Liver Disease and Transplantation
- Odor and Emission Control Technologies
- Wave and Wind Energy Systems
- Noise Effects and Management
- Food Quality and Safety Studies
- Structural Load-Bearing Analysis
Center for Global Health
2024
National Center for Global Health and Medicine
2023-2024
The University of Tokyo
2010-2023
Seinan Gakuin University
2021-2023
Institute of Livestock and Grassland Science
2009-2021
University of Tokyo Hospital
2007-2021
Kyoto University
1996-2017
San-ikukai Hospital
2015
National Agriculture and Food Research Organization
2009-2015
Tokyo Metropolitan Geriatric Hospital
1993-2015
The adaptor protein STING recruits a kinase and transcription factor to mediate responses cytosolic DNA.
Obesity defined by body mass index (BMI) significantly increases the risk of hepatocellular carcinoma (HCC). In contrast, not only obesity but also underweight is associated with poor prognosis in patients HCC. Differences composition rather than BMI were suggested to be true determinants prognosis. However, this hypothesis has been demonstrated conclusively.We measured skeletal muscle (SMI), mean attenuation (MA), visceral adipose tissue index, subcutaneous and area ratios (VSR) via...
Abstract Mutations in the PIK3CA gene, which encodes p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), have been reported human cancers, including colorectal cancer. Most mutations cluster at hotspots within helical and kinase domains. Whereas H1047R, one hotspot mutants, is to elevated lipid activity, functional consequences other not examined. In this study, we examined effects colon cancer–associated on activity vitro, activation downstream targets Akt p70S6K vivo NIH...
Round the twist: Metalation of [36]octaphyrin 1 provided Möbius aromatic Pd2 complex 3 as well Hückel antiaromatic 2. This method can be applied to other expanded porphyrins and Group 10 metal ions. The aromatic/antiaromatic character was supported by NMR spectrscopy, NICS calculation, two-photon absorption measurements. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704407_s.pdf or from author. Please note: publisher not...
Objective Metabolic reprogramming of tumour cells that allows for adaptation to their local environment is a hallmark cancer. Interestingly, obesity-driven and non-alcoholic steatohepatitis (NASH)-driven hepatocellular carcinoma (HCC) mouse models commonly exhibit strong steatosis in as seen human steatohepatitic HCC (SH-HCC), which may reflect characteristic metabolic alteration. Design Non-tumour tissues obtained from diethylnitrosamine-injected mice fed either normal or high-fat diet...
Abstract Ruthenium complexes, e.g., Ru(H)2(CO)(PPh3)3, have been found to catalyze the addition of ortho C–H bonds aromatic ketones olefins with a high degree efficiency and selectivity. 2′-Methylacetophenone reacts various types terminal give 1 : coupling products in good excellent yields. The C–C bond formation takes place exclusively at carbon atom except for styrene which affords mixture two regioisomers. Acetylnaphthalenes, cyclic ketones, heteroaromatic also react triethoxyvinylsilane...
The interaction between the chemokine receptor CXCR4 and its specific ligand, stromal cell-derived factor-1 (SDF-1/CXCL12), mediates several cellular functions. In cancer, SDF-1-positive or CXCR4-positive cells of various lineages are detected within tumor tissues. Recent intensive research has indicated possibility that blocking could reduce metastatic potential cancer cells. Here, we show inhibition SDF-1/CXCR4 axis decreases growth s.c. gastrointestinal tumors through suppression...
Verwickelt: Metallierung des [36]Octaphyrins 1 lieferte den Möbius-aromatischen Pd2-Komplex 3 sowie Hückel-antiaromatischen 2. Die Synthesemethode kann auf andere Porphyrine und Metallionen der Gruppe 10 übertragen werden. Der aromatische/antiaromatische Charakter wurde durch NMR-Spektroskopie, NICS-Rechnungen Zweiphotonenabsorptionsmessungen bestätigt. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z704407_s.pdf or from...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction (desmoplasia). We have previously reported that mice with conditional KrasG12D mutation and knockout of TGF-β receptor type II (Tgfbr2), PKF mice, develop PDAC desmoplasia modulated CXC chemokines are produced cells through tumor-stromal interaction. In this study, we further discovered cancer-associated fibroblast (CAF) accelerated each other's invasion migration the chemokines-receptor (CXCLs-CXCR2) axis....
Protonation-triggered conformational changes of meso-octakis(pentafluorophenyl) [36]octaphyrin and [38]octaphyrin have been investigated. The X-ray crystal structures (1)H NMR analyses revealed that the protonation process cuts off intramolecular hydrogen bonds between aminic iminic pyrrole units and, at same time, produces intermolecular hydrogen-bond network unit counter-anions. Such a replacement induces some inversion, leading to Mobius aromatic conformation for Huckel [38]octaphyrin....
Abstract The hedgehog and mitogen‐activated protein kinase (MAPK) signaling pathways regulate growth in many tumors, suggesting cooperation between these two the regulation of cell proliferation. However, interactions have not been extensively studied. We assessed cross‐talk MAPK proliferation gastric cancer. showed that PTCH expression was significantly correlated with extracellular signal‐regulated (ERK) 1/2 phosphorylation ( P = 0.016) as well SHH 0.034) 35 cancers by...
Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family chromatin reader have therapeutic efficacy against various malignancies. However, the detailed mechanisms underlying anti-tumor effects in distinct tumor types remain elusive. Here, we show novel antitumor mechanism BET inhibition pancreatic ductal adenocarcinoma (PDAC). We found that JQ1, inhibitor, decreased desmoplastic stroma, hallmark PDAC, suppressed growth patient-derived xenografts (PDX) PDACs. In vivo JQ1...
Abstract Addition of C–H bonds in α,β-enones to olefins were attained by Ru(H)2(CO)(PPh3)3 catalyst. The reactions acylated heterocyclic with triethoxyvinylsilane the presence ruthenium catalyst afforded coupling product good excellent yields. 3,4-dihydro-6-pivaloyl-2H-pyran several also catalyzed complex give corresponding products.
Abstract
When heated, bis-Cu(II) octaphyrin(1.1.1.1.1.1.1.1) is quantitatively split into two Cu(II) porphyrins both in solution and film states, which accompanied by large absorption spectral changes.