A5021468178- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Advanced Causal Inference Techniques
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Statistical Methods and Inference
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Cardiac Valve Diseases and Treatments
- Colorectal Cancer Surgical Treatments
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Vascular Procedures and Complications
- Gastrointestinal motility and disorders
- Liver Disease and Transplantation
- Diabetes Management and Research
- Helicobacter pylori-related gastroenterology studies
Tokyo Medical University
2022-2025
Yokohama City University
2015-2024
The Institute of Statistical Mathematics
2018-2024
University of Tokyo Health Sciences
2009-2024
Tokyo Metropolitan Geriatric Hospital
2023
Sendai Kousei Hospital
2020-2022
Yokohama City University Medical Center
2011-2021
Shimane University
2020-2021
Yokohama City University Hospital
2014-2020
Kyoto University
2020
Noninvasive methods have been evaluated for the assessment of liver fibrosis and steatosis in patients with nonalcoholic fatty disease (NAFLD). We compared ability transient elastography (TE) M-probe, magnetic resonance (MRE) to assess fibrosis. Findings from imaging (MRI)-based proton density fat fraction (PDFF) measurements were those TE-based controlled attenuation parameter (CAP) steatosis.We performed a cross-sectional study 142 NAFLD (identified by biopsy; mean body mass index, 28.1...
Obesity defined by body mass index (BMI) significantly increases the risk of hepatocellular carcinoma (HCC). In contrast, not only obesity but also underweight is associated with poor prognosis in patients HCC. Differences composition rather than BMI were suggested to be true determinants prognosis. However, this hypothesis has been demonstrated conclusively.We measured skeletal muscle (SMI), mean attenuation (MA), visceral adipose tissue index, subcutaneous and area ratios (VSR) via...
RNF213 was recently reported as a susceptibility gene for moyamoya disease (MMD). Our aim to clarify the correlation between genotype and MMD phenotype.The entire coding region of sequenced in 204 patients with MMD, corresponding variants were checked 62 pairs parents, 13 mothers 4 fathers patients, 283 normal controls. Clinical information collected. Genotype-phenotype correlations statistically analyzed.The c.14576G>A variant identified 95.1% familial 79.2% sporadic 1.8% controls, thus...
To determine clinical and genetic features of individuals with relapsing polychondritis (RP) likely caused by pathogenic somatic variants in ubiquitin-like modifier activating enzyme 1 (UBA1).Fourteen patients RP who met the Damiani Levine criteria were recruited (12 men, 2 women; median onset age (IQR) 72.1 years (67.1-78.0)). Sanger sequencing UBA1 was performed using genomic DNA from peripheral blood leukocytes or bone marrow tissue. Droplet digital PCR (ddPCR) peptide nucleic acid...
Breastfeeding self-efficacy interventions are important for improving breastfeeding outcomes. However, the circumstances that may influence effectiveness of unclear, especially in context hospitals with suboptimal infant feeding practices. Thus, we aimed to evaluate effect a intervention on and exclusive breastfeeding, further assessed difference its by hospital-routine type. In this study control group, 781 pregnant women were recruited from 2 "Baby-Friendly"-certified (BFH)...
Background Endothelial dysfunction is a key component of vascular vulnerability. Reactive hyperemia index ( RHI ), as assessed by the peripheral arterial tonometry, can noninvasively evaluate endothelial function. This study was designed to determine additional prognostic value function Synergy Between PCI With Taxus and Cardiac Surgery Score SYNTAX sc) Framingham Risk FRS ) in predicting cardiovascular events high‐risk patients. Methods Results We undertook two‐center prospective 528 stable...
Abstract Kabuki syndrome is a congenital anomaly characterized by developmental delay, intellectual disability, specific facial features including long palpebral fissures and ectropion of the lateral third lower eyelids, prominent digit pads, skeletal visceral abnormalities. Mutations in MLL2 KDM6A cause syndrome. We screened 81 individuals with for mutations these genes conventional methods (n = 58) and/or targeted resequencing 45) or whole exome sequencing 5). identified mutation 50...
// Koji Izumi 1 , Masataka Taguri 2 Hiroshi Miyamoto 3 Yoshinori Hara 4 Takeshi Kishida 5 Kimio Chiba 6 Tetsuo Murai 7 Kotaro Hirai 8 Suzuki 9 Kiyoshi Fujinami 10 Teiichiro Ueki 11 Koichi Udagawa 12 Kazuo Kitami 13 Masatoshi Moriyama 14 Yasuhide Miyoshi 15 Futoshi Tsuchiya 16 Ichiro Ikeda 17 Kazuki Kobayashi 18 Maho Sato Satoshi Morita 19 Kazumi Noguchi Hiroji Uemura Department of Urology, Yokohama City University Graduate School Medicine, Yokohama, Japan Biostatistics and Epidemiology,...
The authors sought to investigate the prevalence, risk factors, and mid-term mortality in Asian patients with prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR).Little information is available on PPM TAVR patients.The included 1,558 enrolled OCEAN-TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry from October 2013 July 2016 excluding who died following before discharge. was defined as moderate if ≧0.65 but ≦0.85 cm2/m2, or...
Glutathione plays crucial roles in the detoxification and antioxidant systems of cells has been used to treat acute poisoning chronic liver diseases by intravenous injection. This is a first study examining therapeutic effects oral administration glutathione patients with nonalcoholic fatty disease (NAFLD). The was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD diagnosed using ultrasonography were prospectively evaluated. All underwent intervention improve their...
The treatment of diabetes has a significant impact on the pathogenesis non-alcoholic fatty liver disease (NAFLD). We compared effectiveness tofogliflozin, selective sodium-glucose cotransporter 2 inhibitor, and pioglitazone for NAFLD patients with type mellitus.
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with nonalcoholic fatty liver disease (NAFLD). In cohorts 409 NAFLD from multiple global regions, we defined and validated hepatic transcriptome serum secretome signatures predictive long-term HCC NAFLD. A 133-gene signature, prognostic signature (PLS)–NAFLD, predicted incident over up to 15 years longitudinal observation. High-risk PLS-NAFLD was associated IDO1 + dendritic cells dysfunctional CD8 T...
Information has been sparse on the comparison of 4 blood pressure (BP) indexes (systolic BP [SBP], diastolic BP, pulse pressure, and mean [MBP]) in relation to long-term incidence stroke myocardial infarction, particularly middle-aged older Asians.The Japan Arteriosclerosis Longitudinal Study Group conducted a meta-analysis 16 cohort studies Japan. A total 48,224 men women 40 89 years age participated at baseline, 1231 events 220 infarction occurred during an average 8.4-year follow-up....
One of the main purposes a phase I dose‐finding trial in oncology is to identify an optimal dose (OD) that both tolerable and has indication therapeutic benefit for subjects subsequent II III trials. Many methods based solely on toxicity considerations have been proposed under assumption efficacy monotonically increase with level. Such may not be necessarily case, however, when evaluating OD molecular targeted, cytostatic, biological agents, as well immune‐oncology therapy. To address this...
Abstract Droplet digital PCR (ddPCR), a method for measuring target nucleic acid sequence quantity, is useful determining somatic mutation rates using TaqMan probes. In this study, the detection limit of copy numbers test DNA by ddPCR was determined based on Poisson distribution. Peptide (PNA), which strongly hybridises to lesions, can inhibit amplification PCR. Therefore, combination with PNA and (PNA–ddPCR), could be lowered. We reanalysed GNAQ (c.548G > A) in patients Sturge–Weber...