A5047542052- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Renal and related cancers
- Extracellular vesicles in disease
- Chronic Myeloid Leukemia Treatments
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Oral health in cancer treatment
- Cancer Immunotherapy and Biomarkers
- Parvovirus B19 Infection Studies
- Mass Spectrometry Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Analytical Chemistry and Chromatography
Osaka Women's and Children's Hospital
2018-2025
Kanagawa Prefectural Hospital Organization
2021-2025
Kanagawa Cancer Center
2021-2025
keiyu Hospital
2011-2024
Universidade do Porto
2023
Osaka Medical Center for Cancer and Cardiovascular Diseases
2010-2020
Hakodate National Hospital
2020
Yamato Municipal Hospital
2020
Keio University
2020
Kitasato University
2020
// Koji Izumi 1 , Masataka Taguri 2 Hiroshi Miyamoto 3 Yoshinori Hara 4 Takeshi Kishida 5 Kimio Chiba 6 Tetsuo Murai 7 Kotaro Hirai 8 Suzuki 9 Kiyoshi Fujinami 10 Teiichiro Ueki 11 Koichi Udagawa 12 Kazuo Kitami 13 Masatoshi Moriyama 14 Yasuhide Miyoshi 15 Futoshi Tsuchiya 16 Ichiro Ikeda 17 Kazuki Kobayashi 18 Maho Sato Satoshi Morita 19 Kazumi Noguchi Hiroji Uemura Department of Urology, Yokohama City University Graduate School Medicine, Yokohama, Japan Biostatistics and Epidemiology,...
Abstract We investigated the efficacy of a Wilms' tumor gene 1 (WT1) vaccine combined with gemcitabine (GEMWT1) and compared it (GEM) monotherapy for advanced pancreatic ductal adenocarcinoma (PDAC) in randomized phase II study. randomly assigned HLA-A*02:01– or HLA-A*24:02–positive patients PDAC to receive GEMWT1 GEM. assessed WT1-specific immune responses via delayed-type hypersensitivity (DTH) WT1 peptide tetramer assay detect cytotoxic T lymphocytes (WT1-CTL). Of 91 enrolled, 85 were...
To compare the different stem cell sources used in salvage transplantation for graft failure (GF) after cord blood (CBT), we retrospectively analyzed data of 220 patients who developed GF undergoing CBT between January 2001 and December 2007 underwent a second hematopoietic (HSCT) within 3 months. The donor HSCT were (n = 180), peripheral cells (PBSCs; n 24), bone marrow (BM; 16). cumulative incidence neutrophil engraftment on day 30 was 39% with CB, 71% PBSCs, 75% BM. Multivariate analysis...
Abstract Anti-human leukocyte antigen (HLA) antibodies, particularly donor-specific HLA antibodies (DSA), negatively impact engraftment in hematopoietic cell transplantation. Past studies have proposed various interventions to reduce DSA, but these were primarily from single centers and not large-scale registry data. Therefore, we conducted a retrospective analysis of nationwide data examine the effects anti-HLA on engraftment. Evaluable patients classified into an antibody-negative group (...
Although chemoradiotherapy is considered an efficacious treatment option for patients with locally advanced rectal cancer, the associated radiological toxicities and late anal dysfunction are concerning issues. Herein, we examined efficacy safety of folinic acid, 5-fluorouracil, oxaliplatin, irinotecan (FOLFOXIRI) as upfront therapy marginally unresectable local cancers without distant metastasis. This multicenter, prospective, observational study was designed by Yokohama Colorectal Cancer...
Background Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of infancy or early childhood. To clarify the incidence and subtypes FHL in Japan, we performed genetic functional analyses cytotoxic T lymphocytes (CTLs) Japanese patients with FHL. Design Methods Among children (HLH) registered at our laboratory, those more than one following findings were eligible for study entry under diagnosis FHL: positive known mutations, family history HLH, impaired CTL-mediated...
Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for juvenile myelomonocytic leukemia (JMML), but few large studies of HSCT JMML exist. Using data from Japan Society Cell Transplantation registry, we analyzed outcomes 129 children with who underwent between 2000 and 2011. The 5-year overall survival (OS) rate cumulative incidence relapse were 64% 34%, respectively. A regimen busulfan/fludarabine/melphalan was most commonly used (59 patients) provided best...
Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent young adult (AYA) patients remain unclear. We compared after HSCT ALL among children (age 1 to 9 years; n = 607), adolescents 10 19 783), adults 20 29 years old, 603), based on Japanese nationwide registry data. The 5-year overall survival (OS) rate AYA was worse than that of children, at 64% (95% confidence...
The effects of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on systemic chronic active Epstein-Barr virus infection (sCAEBV) are yet to be analyzed in a large number patients. Using the Japanese registry database, Transplant Registry Unification Management Program, we investigated outcomes 102 sCAEBV patients who underwent allo-HSCT. median age at HSCT was 21 years, and three-year overall survival (3-year OS) rate 72.5%. Of 90 whose viral load after allo-HSCT evaluated, 56...
Summary Patients with acute megakaryoblastic leukaemia of Down syndrome (DS‐AMKL) have an excellent survival rate; however, patients non‐DS‐AMKL experience poor outcomes. Therefore, this study retrospectively analysed 203 children who underwent their first haematopoietic cell transplantation (HCT) from 1986 to 2015 using a nationwide Japanese HCT registry data assess outcomes for non‐DS‐AMKL. The 5‐year overall (OS) and event‐free (EFS) rates were 43% 38% respectively. OS rate was...
The clinical course of age-related macular degeneration (AMD) is related to choroidal conditions, and can be determined by the evaluation central thickness (CCT). aim this study was determine association between axial length (AL) in AMD measuring these parameters patients with without AMD. Seventy eyes 70 (34 men 36 women; age, 64–88 years; mean 77.0 ± 6.5 years) who underwent cataract surgery from February 2015 March 2020 at Department Ophthalmology, Keio University School Medicine were...
Simpson-Golabi-Behmel syndrome is a congenital malformation associated with mutations in GPC3, which located the Xq26 region. Three new loss-of-function and global X-chromosome rearrangement involving GPC3 were identified. A female sibling of patient, who presented cleft palate hepatoblastoma, carries same chromosomal paradoxical pattern inactivation. These findings support variable alterations, possible mechanism patients.
The breakthrough effects of tyrosine kinase inhibitors (TKIs) have lessened indications for allogeneic hematopoietic stem cell transplantation (HSCT) in chronic myeloid leukemia (CML). However, HSCT is still attractive children and adolescents/young adults (AYAs) requiring lifelong TKI therapy. Nevertheless, little has been reported on the outcomes large clinical studies targeting these age groups. This study aimed to identify prognostic factors HSCT, including reduced-intensity conditioning...