A5056452521- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- Immunodeficiency and Autoimmune Disorders
- Pancreatic and Hepatic Oncology Research
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Blood disorders and treatments
- Protein Tyrosine Phosphatases
- Cytomegalovirus and herpesvirus research
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Fungal Infections and Studies
Nihon University
2015-2024
Japanese Foundation For Cancer Research
2024
Kyoto University
2015-2024
Japanese Red Cross Nagoya Daiichi Hospital
2012-2024
Cancer Hospital and Research Institute
2024
Nagoya University
2003-2023
Waseda University
2023
Kansai Medical University
2023
Iwate University
2023
The Japanese Data Center for Hematopoietic Cell Transplantation
2023
Ikaros/IKZF1 is an essential transcription factor expressed throughout hematopoiesis. IKZF1 implicated in lymphocyte and myeloid differentiation negative regulation of cell proliferation. In humans, somatic mutations have been linked to the development B acute lymphoblastic leukemia (ALL) children adults. Recently, heterozygous germline identified patients with a immune deficiency mimicking common variable immunodeficiency. These demonstrated incomplete penetrance led haploinsufficiency....
The current treatment approach for severe aplastic anemia in children is based on studies performed the 1980s, and updated evidence required. We retrospectively compared outcomes of with acquired who received immunosuppressive therapy within prospective trials conducted by Japanese Childhood Aplastic Anemia Study Group or underwent bone marrow transplantation from an HLA-matched family donor registered Society Hematopoietic Cell Transplantation Registry. Between 1992 2009, 599 (younger than...
Purpose Acute lymphoblastic leukemia (ALL) makes up a significant proportion of all pediatric cancers, and relapsed ALL is leading cause cancer-associated deaths in children. Identification risk factors druggable molecular targets can lead to better stratification treatments subsequent improvement prognosis. Patients Methods We enrolled 59 children with or primary refractory who were treated our institutions. primarily performed RNA sequencing (RNA-seq) using patients’ leukemic cells...
To characterize childhood acute megakaryoblastic leukaemia (AMKL), we reviewed 45 children with AMKL diagnosed between 1986 and 2005 at Nagoya University Hospital Japanese Red Cross First Hospital. Twenty-four patients (53%) had associated Down syndrome (DS-AMKL) 21 (47%) non-DS-AMKL. The median age of the DS-AMKL was months (range, 8-38 months) that non-DS-AMKL 15 2-185 months). morphology blast cells categorized into three groups according to stage megakaryocyte maturation. were more...
Mutations in NF1, PTPN11, NRAS, KRAS and CBL have been reported to play a pathogenetic role juvenile myelomonocytic leukaemia (JMML), rare myelodyplastic/myeloproliferative neoplasm occurring children. Recently, mutations ASXL1 were identified chronic other myeloid malignancies. We sequenced exon 12 of ASLX1 49 JMML patients, found 2 novel heterozygous (nonsense frameshift) mutations, one as sole lesion, the was conjunction with PTPN11 mutation. cooperates KDM1A transcriptional repression...
Pancreatic ductal adenocarcinoma (PDAC), a poor prognostic cancer, commonly develops following activating mutations in the KRAS oncogene. Activation of WNT signaling is also observed PDAC. To ascertain impact postnatal activation WNT-stimulated pathways PDAC development, we combined Elastase-tva-based RCAS-TVA pancreatic cancer model with established LSL-KrasG12D, Ptf1a-cre model. Delivery RCAS viruses encoding β-cateninS37A and WNT1 stimulated progression premalignant intraepithelial...
In aplastic anemia, predictive markers of response to immunosuppressive therapy have not been well defined. We retrospectively evaluated whether clinical and laboratory findings before treatment could predict in a pediatric cohort from the multicenter AA-97 study Japan. Between 1997 2006, 312 newly diagnosed children were enrolled treated with combination antithymocyte globulin cyclosporine. multivariate analyses, lower white blood cell count was most significant marker better response;...
Background: Voriconazole is a triazole antifungal agent with potent activity against broad spectrum of pathogens, including Aspergillus and Candida species. In human adults, allelic polymorphisms CYP2C19 are known to correlate significant variation in voriconazole plasma concentration. Here, we report an analysis phenotype concentrations children. Methods: This retrospective study included 37 children who had measured from May 2006 June 2011. All single-nucleotide that define the 3 major...
Predicting the response to immunosuppressive therapy could provide useful information help clinician define treatment strategies for patients with aplastic anemia. In our current study, we evaluated relationship between telomere length of lymphocytes at diagnosis and in 64 children anemia, using flow fluorescence situ hybridization. Median age was ten years (range 1.5-16.2 years). Severity disease classified as very severe 23, 21, moderate 20 patients. All were enrolled multicenter studies...
Aplastic anaemia (AA) is defined as a pancytopenia caused by bone marrow failure, and its pathogenesis thought to involve autoimmune processes. Several predictive markers of the response immunosuppressive therapy (IST) have been proposed, which appear reflect immune pathophysiology. We prospectively investigated presence human leucocyte antigen (HLA)-DR15, minor population paroxysmal nocturnal haemoglobinuria (PNH)-type cells, antibodies recently identified autoantigen postmeiotic...
We assessed the clinical utility of next-generation sequencing (NGS)-based monitoring minimal residual disease (MRD) in a uniformly treated cohort 79 patients with paediatric B-cell acute lymphoblastic leukaemia. Bone marrow samples were collected at time diagnosis, days 33 and 80, pre- (4-5 months) post- (24 maintenance therapy points, relapse. identified leukaemia-specific CDR3 sequences 72 (91%) detected MRD 59 232 samples. Although was 28 55 (51%) on day 33, frequencies detection...
A macro-/mesoporous Co-N-C-decorated separator is proposed to confine and reutilize migrating polysulfides. Endowed with a desirable structure synchronous lithio- sulfiphilic chemistry, the Co-N-C interface manipulates large polysulfide adsorption uptake, enabling good kinetics, reversible electrocatalysis toward redox of anchored polysulfides, facile charge transport. It significantly boosts performance simple 70 wt % S/MWCNTs (MWCNTs=multi-walled carbon nanotubes) cathode, achieving high...