A5030299290- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Blood transfusion and management
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Blood groups and transfusion
- Parvovirus B19 Infection Studies
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Hemoglobinopathies and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Neonatal Health and Biochemistry
- Neutropenia and Cancer Infections
- Cancer Immunotherapy and Biomarkers
- Blood donation and transfusion practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
Shinshu University Hospital
2016-2025
Shinshu University
2011-2024
Nagano Children's Hospital
2015-2024
Pediatrics and Genetics
2017-2018
Ōtani University
2004-2015
Texas Children's Hospital
2012-2014
Baylor College of Medicine
2012-2014
Methodist Hospital
2012-2014
Houston Methodist
2012-2014
Asahikawa Medical University
2012
Severe and fatal viral infections remain common after hematopoietic stem cell transplantation. Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for Epstein–Barr virus (EBV), cytomegalovirus (CMV), adenoviral antigens can treat that are impervious to conventional therapies, but broader implementation extension additional viruses is limited by competition between virus-derived time-consuming laborious manufacturing procedures. We now describe a system rapidly generates single...
The success of adoptively transferred tumor-directed T cells requires them to survive and expand in vivo. Most tumors, however, employ immune evasion mechanisms, including the production inhibitory cytokines that limit vivo T-cell persistence effector function. To protect from such negative influences, we generated a chimeric cytokine receptor which interleukin (IL) 4 exodomain was fused IL7 endodomain. We thereby inverted effects tumor-derived IL4 so proliferation activation tumor directed...
Background/Aim: Wilms9 tumor 1 (WT1) is a tumor-associated antigen highly expressed in cancer. We examined the safety of WT1-peptide pulsed dendritic cell (WT1-DC) vaccine combination with chemotherapy patients surgically resected pancreatic Patients and Methods: Eight resectable cancer undergoing surgery either combined S-1 or plus gemcitabine therapy were enrolled. Immunohistochemical analysis WT1 was performed 34 cases Results: No serious side-effects observed, except grade I fever five...
Epstein-Barr virus (EBV) is the pathogen that most commonly triggers infection-associated hemophagocytic lymphohistiocytosis (HLH) and ectopically infects CD8(+) T cells in EBV-associated HLH (EBV-HLH). We recently described an EBV-HLH patient who had a clonally expanded population of EBV-infected with CD5 down-regulation. To determine whether this finding could serve as useful marker for EBV-HLH, we investigated 5 additional patients. found significant increase subpopulation down-regulation...
Although the hematopoietic cell transplantation (HCT)-comorbidity index (HCT-CI) score is associated with an increased risk of mortality after allogeneic HCT, it remains unclear how pre-HCT liver dysfunction affects clinical outcomes. We retrospectively compared HCT outcomes among four groups stratified according to presence HCT-CI and other organ scores, using a Japan transplant registry database between 2010 2020. Of 14235 recipients, 1527 tested positive for including HBV or HCV hepatitis...
Background Diamond-Blackfan anemia is a rare, clinically heterogeneous, congenital red cell aplasia: 40% of patients have abnormalities. Recent studies shown that in western countries, the disease associated with heterozygous mutations ribosomal protein (RP) genes about 50% patients. There been no to determine incidence these Asian anemia.Design and Methods We screened 49 Japanese (45 probands) for six known anemia: RPS19, RPS24, RPS17, RPL5, RPL11, RPL35A. RPS14 was also examined due its...
Allergic transfusion reactions (ATRs) and febrile non-haemolytic (FNHTRs) are the two major types of transfusion-related adverse (TRARs). Although prestorage leucocyte reduction diversion first aliquot blood (LR/D) could reduce FNHTRs bacterial contamination in adult transfusion, ATRs still problematic. In addition, there is little information about TRARs paediatric population.We conducted a single-centre retrospective analysis all transfusions, except washing products, for 153 months to...
Background Allergic transfusion reactions ( ATR s), particularly those caused by plasma‐rich platelet concentrates P ‐ PC are an important concern in medicine. Replacing PCs with containing M ‐sol ‐sol‐ R s) is expected to prevent s. However, this has not yet been verified sufficient clinical evidence. Study Design and Methods A retrospective cohort study was performed between 2008 2011. Pediatric patients hematologic disorders, solid tumors, primary immunodeficiency or inherited metabolic...
To evaluate minimal residual disease (MRD) after chemotherapy and haematopoietic stem cell transplantation in juvenile myelomonocytic leukaemia (JMML), a locked nucleic acid-allele specific quantitative polymerase chain reaction (LNA-AS-qPCR) was developed for 13 patients (four types of PTPN11 mutation four RAS mutation). The post-transplant MRD detected by LNA-AS-qPCR analysis well correlated with chimerism assessed short tandem repeat PCR analysis. Non-intensive exerted no substantial...
Abstract Background and objectives Like adults, children can have allergic transfusion reactions (ATRs) febrile non‐haemolytic (FNHTRs). But published information about the incidence of paediatric ATR FNHTR is scarce. Materials methods This retrospective study was conducted from April 2002 to June 2018 on who had ATRs and/or FNHTRs platelet (PLT), red blood cell (RBC) or washed PLT/RBC concentrate transfusions. We analysed ATR/FNHTR clinical presentations, such as severity, time occurrence...