A5009684011- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Neurogenetic and Muscular Disorders Research
- HIV/AIDS drug development and treatment
- CAR-T cell therapy research
- Alzheimer's disease research and treatments
- Chronic Myeloid Leukemia Treatments
- HIV Research and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Circular RNAs in diseases
- Lymphoma Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Neuroblastoma Research and Treatments
- Mechanical Circulatory Support Devices
- Neuroinflammation and Neurodegeneration Mechanisms
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
Nagoya University
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
University of Oxford
2022-2024
John Radcliffe Hospital
2022-2024
National Heart Lung and Blood Institute
2024
Zhengzhou University
2021
Shenzhen Luohu People's Hospital
2021
Shenzhen University
2021
Peking Union Medical College Hospital
2018-2019
Second Affiliated Hospital of Zhengzhou University
2019
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant hexanucleotide repeat expansion (HRE) mutation in C9orf72 . Here, we study its consequences for microglial function using human iPSC-derived By RNA-sequencing, identify enrichment pathways associated immune cell activation and...
Liver cancer is the sixth most prevalent cancer, and third frequent cause of cancer-related deaths. Circular RNAs (circRNAs), a kind special endogenous ncRNAs, have been coming back to forefront genomics research. In this study, we used systems biology approach construct analyze circRNA molecular regulatory networks in context liver cancer. We detected total 127 differentially expressed circRNAs 3,235 mRNAs. selected top-5 upregulated circRNA-miRNA-mRNA network. enriched pathways gene...
Abstract Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor degeneration with additional involvement of non-neuronal cells, in particular, microglia. In previous work, we have established protocols for the differentiation iPSC-derived spinal neurons and Here, combine both cell lineages establish a novel co-culture microglia, which is compatible identity function. Co-cultured microglia express key markers transcriptomically resemble primary human...
// Zhendong Su 1 , Satoshi Kishida Shoma Tsubota Kazuma Sakamoto Dongliang Cao Shinichi Kiyonari Miki Ohira 2 Takehiko Kamijo Atsushi Narita 3 Yinyan Xu Yoshiyuki Takahashi and Kenji Kadomatsu Department of Biochemistry, Nagoya University Graduate School Medicine, Nagoya, Aichi, Japan Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Pediatrics, Correspondence to: Kadomatsu, email: kkadoma@med.nagoya-u.ac.jp Keywords: NCAN; CSPG; neuroblastoma; tumor sphere Received:...
Urothelial bladder cancer (UBC) is a common malignant tumor of the urogenital system with high rate recurrence. Due to sophisticated and largely unexplored mechanisms tumorigenesis UBC, classical therapeutic approaches including transurethral resection radical cystectomy combined chemotherapy have remained unchanged for decades. However, increasingly in-depth understanding microenvironment composition tumor-infiltrating lymphocytes novel immunotherapeutic strategies been developed. Bacillus...
Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is intractable pediatric myeloid neoplasm. Epigenetic regulation transcription, particularly by CpG methylation, plays important role in tumor progression, mainly repressing tumor-suppressor genes. To clarify the clinical importance aberrant DNA we studied hypermethylation status 16 target genes genomes 92 patients with JMML bisulfite conversion and pryosequencing technique. Among candidate...
To characterize the patterns of brain atrophy and perfusion as measured by arterial spin labeling (ASL)-MRI, in amyotrophic lateral sclerosis (ALS) patients with varying levels cognitive deficit, including ALS frontotemporal dementia (FTD).A total 55 20 healthy controls (HCs) were included, all participants underwent neuropsychological assessments MRI scans. According to their performance, further subclassified into normal cognition (ALS-Cn, n = 27), impairment (ALS-Ci, 17), ALS-FTD (n 11)....
Induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) from patients with amyotrophic lateral sclerosis (ALS) and the C9ORF72 hexanucleotide repeat expansion (HRE) have multiple cellular phenotypes, but which of these accurately reflect biology underlying cell-specific vulnerability ALS is uncertain. We therefore compared phenotypes due to HRE in MNs sensory (SNs), are relatively spared ALS. The iPSC models were able partially reproduce differential gene expression seen between...
Background: Ongoing efforts have been made to identify new neuroimaging markers track amyotrophic lateral sclerosis (ALS) progression. This study aimed explore the monitoring value of multimodal magnetic resonance imaging (MRI) in disease progression ALS. Methods: From September 2015 March 2017, ten patients diagnosed with ALS Peking Union Medical College Hospital completed head MRI scans at baseline and during follow-up. Multimodal analyses, including gray matter (GM) volume measured by...
Myelodysplastic/myeloproliferative uclassifiable (MDS/MPN-U) is a rare myeloid neoplasm characterized by myelodysplasia and myeloproliferation at the time of initial presentation, which usually diagnosis exclusion. The molecular pathogenesis MDS/MPN-U patients remains to be elucidated. Among five diagnosed with MDS/MPN-U, three harboured RUNX1 (AML1) mutations; one carried somatic mosaicism mutation JAK2(V617F) had dual FLT3-internal tandem duplication mutations progression acute leukaemia...
Introduction Paraquat (PQ) is a widely used herbicide which inexpensive and easily accessible for people in rural areas. A small amount of PQ ingestion could be lethal, yet currently, the optimal treatment still controversial. Extracorporeal therapies (ECTR) have been practised poisoning management, though limited evidence obtained to suggest its superiority over conservative therapy. Haemodialysis (HD) haemoperfusion (HP) are most commonly used, while some institutions also choose HP–HD...
To compare the accuracy of magnetic resonance-guided prostate biopsy (MR-GPB) and template-guided transperineal saturation (TTPSB).A total 219 patients with elevated prostate-specific antigen, abnormal digital rectal examination or ultrasound findings were enrolled. All underwent multiparametric resonance image (mpMRI). Patients a Prostate Imaging Reporting Data System (PI-RADS) score 3 to 5 MR-GPB using 2 cores then immediately an 11-region TTPSB. PI-RADS 1 TTPSB alone. We compared...
The clinical presentation in Chinese patients with sporadic Creutzfeldt-Jakob disease (sCJD) may be unique due to the big difference codon 129 polymorphism of prion protein gene ( PRNP ). This study retrospectively reviewed 26 cases sCJD diagnosed a single center recent years. All received brain magnetic resonance imaging scan, cerebrospinal fluid 14-3-3 detection, electroencephalogram, and screening. were all homozygous MM patients. main onset symptoms rapidly progressive dementia, visual...
Background Distinguishing hypocellular refractory cytopenia of childhood (RCC) from aplastic anemia (AA) is challenging. Thus far, no studies have compared the cytokine profiles in patients with AA to those RCC. In present study, we addressed whether thrombopoietin (TPO) and interleukin 17 (IL‐17) plasma levels are useful for differentiating between two diseases. Methods We measured endogenous concentrations TPO IL‐17 29 AA, 34 RCC, 31 healthy controls using sensitive enzyme‐linked...
Cerebral amyloid angiopathy (CAA)-related inflammation (CAA-RI) is a rare CAA variant characterized by acute or subacute encephalopathy, headache, epilepsy, focal neurological deficits. Radiologically, CAA-RI presents with widespread white matter lesions on brain magnetic resonance imaging in addition to the hemorrhagic features of CAA. Previous studies have found that apolipoprotein E (ApoE) ε4 allele and ε4/ε4 genotype were over-represented CAA-RI. The role ApoE ε2 CAA-RI, however, largely...