A5055454866- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Geological and Geochemical Analysis
- Geochemistry and Geologic Mapping
- MicroRNA in disease regulation
- Immune cells in cancer
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Acupuncture Treatment Research Studies
- Micro and Nano Robotics
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- earthquake and tectonic studies
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Traditional Chinese Medicine Studies
Shenzhen University
2016-2025
Sun Yat-sen University
2015-2025
Jilin University
2012-2025
Southern Medical University Shenzhen Hospital
2023-2025
Jiangyin People's Hospital
2011-2025
Shenzhen Luohu People's Hospital
2016-2025
First Hospital of Jilin University
2012-2025
Changchun University
2025
Jining Medical University
2025
Nottingham Trent University
2021-2025
Abstract The utility of circulating tumor DNA (ctDNA) as a biomarker in patients with advanced cancers receiving immunotherapy is uncertain. We therefore analyzed pretreatment (n = 978) and on-treatment 171) ctDNA samples across 16 advanced-stage types from three phase I/II trials durvalumab (± the anti-CTLA4 therapy tremelimumab). Higher variant allele frequencies (VAF) were associated poorer overall survival (OS) other known prognostic factors, but not objective response, suggesting role...
Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for site-specific treatment of tumors with great depth penetration. The design nano-sonosensitizers suitable SDT bladder cancer (BCa) post-intravesical instillation has not yet been reported. Herein, transmucosal oxygen-self-production nanoplatform developed to achieve highly efficient against BCa. In this system, fluorinated chitosan (FCS) synthesized as effective nontoxic delivery carrier assemble...
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly the Asian patient population. Here we conducted whole exome (WES) and transcriptomic primary tumors from 99 Chinese SCLC patients. Dysregulation tumor suppressor TP53 RB1 was observed 82% 62% patients, respectively, more than half patients (62%)...
Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain have an extremely poor prognosis and low response rates to anti-PD-1/L1 immune checkpoint therapy compared those at other sites. Therefore, it is urgent investigate underlying mechanism resistance develop more effective immunotherapy strategies these patients. Using single-cell RNA sequencing, a high-resolution map entire tumor ecosystem based on 44 473 cells from cancer metastases...
Circular RNA (circRNA) represents a broad and diverse endogenous RNAs that can regulate gene expression in cancer. However, the regulation function of bladder cancer (BC) circRNAs remain largely unknown. Here we generated circRNA microarray data from three BC tissues paired non-cancerous matched tissues, detected circular RNA-cTFRC up-regulated correlated with tumor grade poor survival rate patients. We subsequently performed functional analyses cell lines an animal model to support clinical...
Abstract Background Metastasis of breast cancer have caused the majority cancer-related death worldwide. The circRNAs are associated with tumorigenesis and metastasis in according to recent research. However, biological mechanism liver metastatic remains ambiguous yet. Methods Microarray analysis three pairs primary BC tissues matched hepatic specimens identified circEZH2. We used RT-qPCR FISH assays confirm circEZH2 existence, characteristics, expression. Both vivo vitro, played an...
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression greatly facilitated by circKIF4A, but uncertainty remains regarding its role in brain and molecular mechanism. In this study, we found notable upregulation circKIF4A cell lines metastases. Inhibition impaired ability to proliferate, migrate, metastasis. Luciferase reporter assays confirmed competed for binding miR-637 STAT3 3’ UTR....
Fatty acid metabolism has been deciphered to augment tumorigenesis and disease progression in addition therapy resistance via strengthened lipid synthesis, storage, catabolism. Breast cancer is strongly associated with the biological function of fatty owing abundant presence adipocytes breast tissue. It unraveled that tumor cells exhibit considerable plasticity based on metabolism, responding extra-tumoral a range metabolic signals, which microenvironment plays pivotal role. However,...
Breast cancer (BC) is the most common and top cause of female mortality worldwide. The prognosis for patients with breast liver metastasis (BCLM) remains poor. Emerging studies suggest that circular RNAs (circRNAs) are associated progression BC. Exploration circRNAs presents a promising avenue identifying metastasis-targeting agents improving BCLM. Microarray bioinformatic analyses were used to analyze differentially expressed between three pairs BCLM primary roles hsa_circ_0060467...
Nanorobotic manipulation to access subcellular organelles remains unmet due the challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as mitochondria, are an emerging therapeutic target with selective targeting and curative efficacy. We report autonomous nanorobot capable of active mitochondria-targeted drug delivery, prepared by facilely encapsulating mitochondriotropic doxorubicin-triphenylphosphonium (DOX-TPP) inside zeolitic imidazolate framework-67...
Abstract N6-Methyladenosine (m6A) is the most prevalent internal modification of mammalian mRNAs. Recent studies have shown that m6A methyltransferases METTL3 and METTL14 play important roles in urothelial bladder carcinoma (BLCA). To provide a more comprehensive understanding regulatory landscape cancer, we investigated role YTHDF2, crucial reader, BLCA. YTHDF2 was frequently upregulated at both RNA protein level Functionally, promoted proliferation tumor growth BLCA cells vitro vivo,...
Abstract Microscale organisms and specialized motile cells use protein-based spring-like responsive structures to sense, grasp move. Rendering this biomechanical transduction functionality in an artificial micromachine for applications single-cell manipulations is challenging due the need a bio-applicable nanoscale spring system with large programmable strain response piconewton-scale forces. Here we present three-dimensional nanofabrication monolithic integration, based on acrylic elastomer...