A5057541113- Evolution and Genetic Dynamics
- Modular Robots and Swarm Intelligence
- Origins and Evolution of Life
- Gene Regulatory Network Analysis
- Evolutionary Game Theory and Cooperation
- Advanced biosensing and bioanalysis techniques
- Electrowetting and Microfluidic Technologies
- RNA and protein synthesis mechanisms
- Microfluidic and Capillary Electrophoresis Applications
- DNA and Biological Computing
- Evolutionary Algorithms and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cellular Automata and Applications
- Advanced Thermodynamics and Statistical Mechanics
- Advanced Sensor and Energy Harvesting Materials
- DNA and Nucleic Acid Chemistry
- Micro and Nano Robotics
- Advanced Memory and Neural Computing
- Advanced Materials and Mechanics
- Analytical Chemistry and Sensors
- Molecular Junctions and Nanostructures
- Spectroscopy and Quantum Chemical Studies
- Computability, Logic, AI Algorithms
- Photoreceptor and optogenetics research
- Bacteriophages and microbial interactions
Chemnitz University of Technology
2023-2024
European Centre for Living Technology
2006-2024
Ca' Foscari University of Venice
2018-2024
Ruhr University Bochum
2007-2018
University of Southern Denmark
2009-2016
University of Oxford
1981-2009
Santa Fe Institute
2007
Expro (United States)
2007
Fraunhofer Institute for Applied Information Technology
2001-2002
FZI Research Center for Information Technology
2000-2002
A novel application of dynamic programming to the folding problem for RNA enables one calculate full equilibrium partition function secondary structure and probabilities various substructures. In particular, both all base pairs are computed by a recursive scheme polynomial order N3 in sequence length N. The temperature dependence gives information about melting behavior structure. pair binding probabilities, computation which depends on function, visually summarized "box matrix" display this...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular quasi-speciesManfred Eigen, John McCaskill, and Peter SchusterCite this: J. Phys. Chem. 1988, 92, 24, 6881–6891Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/j100335a010https://doi.org/10.1021/j100335a010research-articleACS PublicationsRequest reuse permissionsArticle Views1524Altmetric-Citations433LEARN ABOUT THESE METRICSArticle...
Abstract Microscale organisms and specialized motile cells use protein-based spring-like responsive structures to sense, grasp move. Rendering this biomechanical transduction functionality in an artificial micromachine for applications single-cell manipulations is challenging due the need a bio-applicable nanoscale spring system with large programmable strain response piconewton-scale forces. Here we present three-dimensional nanofabrication monolithic integration, based on acrylic elastomer...
Choreographing the adaptive shapes of patterned surfaces to exhibit designable mechanical interactions with their environment remains an intricate challenge. Here, a novel category strain-engineered dynamic-shape materials, empowering diverse multi-dimensional shape modulations that are combined form fine-grained microarchitectures is introduced. Using micro-origami tessellation technology, heterogeneous materials provided strategic creases featuring stimuli-responsive micro-hinges morph...
This article lists fourteen open problems in artificial life, each of which is a grand challenge requiring major advance on fundamental issue for its solution. Each problem briefly explained, and, where deemed helpful, some promising paths to solution are indicated.
We describe a stochastic dynamics of tissue cells with special emphasis on epithelial and fibro- blasts fibrocytes the connective tissue. Pattern formation growth characteristics such cell populations in culture are investigated numerically by Monte Carlo simulations for quasi-two-dimensional systems cells. A number quantitative predictions obtained which may be confronted experimental results. Furthermore we introduce several biologically motivated variants our basic model briefly discuss...
Localization in the space of mutant sequences an equilibrium distribution independently self-replicating macromolecules or quasispecies, as described by deterministic evolution equations Eigen (1971) is necessary for a dynamically stable, finite population and simple Darwinian selection particular genotype. In this work, localization properties are investigated functional probability (possibly continuous) replication rates different mutants, including neutral mutation extreme. The central...
Populations of short self-replicating RNA variants have been confined to one side a reaction-diffusion traveling wave front propagating along thin capillary tubes containing the Q beta viral enzyme. The propagation speed is accurately measurable with magnitude about 1 micron/sec, and persists for hundreds generations (of duration less than min). Evolution occurs in wavefront, as established by velocity changes gel electrophoresis samples drawn from capillary. high population numbers...
The error threshold for quasispecies in 1, 2, 3, and infinity dimensions is investigated by stochastic simulation analytically. results show a monotonic decrease the maximal sustainable probability with decreasing diffusion coefficient, independently of spatial dimension. It thereby established that physical interactions between sequences are necessary order effects to enhance stabilization biological information. analytically tractable behavior an infinity-dimensional (simplex) space...
Abstract Drilling wells in high-pressure, high-temperature (HPHT) reservoirs is often characterized by a narrow operating window between formation pore pressure and fracture pressure. Depletion further reduces this window. Managed Pressure (MPD) provides methods for within safe limits the HPHT windows. Exceptional control over downhole pressures can be achieved with advanced MPD technologies that are uniquely suited environment. Such extend achievable targets, yet still have flexibility to...
We here present and characterize a programmable nanoliter scale droplet-on-demand device that can be used separately or readily integrated into low cost single layer rapid prototyping microfluidic systems for wide range of user applications. The passive allows external (off-the-shelf) electronically controlled pinch valves to program the delivery aqueous droplets from up 9 different inputs central outlet channel. either continuous fluid streams microliter plugs embedded in carrier fluid,...
The addressable potential-controlled release of metal ions into electrolyte solutions containing mixtures nucleic acids leads to the ion-guided generation different DNAzymes and activation DNA cascades.
Microelectronic morphogenesis is the creation and maintenance of complex functional structures by microelectronic information within shape-changing materials. Only recently has in-built technology begun to be used reshape materials their functions in three dimensions form smart microdevices microrobots. Electronic that controls morphology inheritable like its biological counterpart, genetic information, set open new vistas leading artificial organisms when coupled with modular design...
Recently, new types of coupled isothermal polynucleotide amplification reactions for the investigation in vitro evolution have been established that are based on multi-enzyme 3SR reaction. Microstructured thin-film open bioreactors constructed our laboratory to run these spatially resolved flow experiments. Artificial DNA/RNA chemistries close biochemistry systems developed, which we studied computer simulations configurable hardware (NGEN). These artificial described level individual...