A5100333659- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Innovative Energy Harvesting Technologies
- Banana Cultivation and Research
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Smart Agriculture and AI
- Inhalation and Respiratory Drug Delivery
- MXene and MAX Phase Materials
- Agriculture Sustainability and Environmental Impact
- Vibration Control and Rheological Fluids
- Chemistry and Stereochemistry Studies
- Immune cells in cancer
- Environmental Engineering and Cultural Studies
- Salivary Gland Disorders and Functions
- Ginseng Biological Effects and Applications
- Antimicrobial agents and applications
- Kruppel-like factors research
- Whipple's Disease and Interleukins
- PI3K/AKT/mTOR signaling in cancer
Shanghai Tenth People's Hospital
2018-2025
Chongqing University
2024
Jiangsu University
2014-2024
Tongji University
2018-2024
Chongqing Cancer Hospital
2024
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2024
Affiliated Hospital of Jiangsu University
2014-2023
Sun Yat-sen University
2022
Sun Yat-sen University Cancer Center
2022
Jiangsu Province Hospital
2021-2022
Abstract Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles largely unknown. Here, we identified that circRNA_104075 (circ_104075) was highly HCC tissues, cell lines serum. Mechanistically, HNF4a bound to the −1409 −1401 region circ_104075 promoter stimulate expression circ_104075. Moreover, acted as a ceRNA upregulate YAP by absorbing miR-582-3p. Interestingly, an N...
Abstract Background Metastasis of breast cancer have caused the majority cancer-related death worldwide. The circRNAs are associated with tumorigenesis and metastasis in according to recent research. However, biological mechanism liver metastatic remains ambiguous yet. Methods Microarray analysis three pairs primary BC tissues matched hepatic specimens identified circEZH2. We used RT-qPCR FISH assays confirm circEZH2 existence, characteristics, expression. Both vivo vitro, played an...
Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are associated with carcinogenesis and metastasis many cancers. Nevertheless, biological mechanisms in breast cancer (BC) liver remain extremely ambiguous.In this study, we identified circROBO1 from three pairs primary BC metastatic sites by RNA sequencing. FISH assays RT-qPCR were conducted to validate existence expression circROBO1. The oncogenic role was demonstrated both...
Antibiotic resistance has become a critical health crisis globally. Traditional strategies using antibiotics can lead to drug-resistance, while inorganic antimicrobial agents cause severe systemic toxicity. Here, we have developed dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which achieve controlled release of clinical levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant P. aeruginosa. Benefiting from the...
The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms pathogenesis EHI have not been fully understood. Circular RNAs (circRNAs) verified as "microRNA sponges" that regulate gene expression through competing endogenous RNA (ceRNA) networks, circRNA profiles their contribution still unclear. Two different libraries were constructed with from human peripheral blood mononuclear cells 3 HARRT-naive patients healthy...
Visual recognition is the most critical function of a harvesting robot, and accuracy action based on performance visual recognition. However, unstructured environment, such as severe occlusion, fruits overlap, illumination changes, complex backgrounds, even heavy fog weather, pose series serious challenges to detection algorithm. Hence, this paper proposes an improved YOLO v4 model, called v4+, cope with brought by environment. The output each Resblock_body in backbone processed using...
Recombinant collagen offers an attractive alternative to the animal-derived collagens in cosmetics and tissue engineering. But its anti-skin-aging effect as food remains unclear. Compared fish bovine collagens, recombinant human (RHC) digestates had a higher Pro content average molecular weight (7222.96 Da). In UVA-damaged skin fibroblasts, RHC increased proliferation 133.41 % migration by 3.23-fold. They decreased ROS levels 54.02 via enhancing activities of superoxide dismutase glutathione...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer deaths worldwide. Significantly activated uridine nucleotide and fatty acid metabolism in HCC cells promote malignant proliferation immune evasion. Herein, it demonstrated that tripartite motif 65 (TRIM65) E3 ubiquitin-protein ligase, O-GlcNAcylated via O-GlcNAcylation transferase, highly expressed facilitated metabolic remodeling to accumulation products related uracil palmitic acid, driving progression HCC. Mechanistically,...
Various polysaccharides purified from plants are considered to be biological response modifiers and have been shown enhance immune responses. Ficus carica L. is a Chinese traditional plant has widely used in Asian countries for its anti-tumor properties. (FCPS), one of the most essential effective components L., beneficial immunomodulator may immunotherapy. However, immunologic mechanism FCPS still unclear. Dectin-1 non-toll-like pattern recognition receptor, predominately expressed on...
Abstract Colorectal cancer (CRC) is the fourth most common in men and third women worldwide. The incidence mortality of CRC was increasing rapidly China. Lymph node-negative colorectal patients with synchronous liver metastasis (LNLM1) defined as “skip” lymph vascular invasion on hepatic metastasis, who presenting poor prognosis. We aiming to investigate potential mechanism for cancer. microarray applied screening transcription landscape circRNA node negative or without (LNLM0). identified...
Angiogenesis is a crucial event in the pathogenesis of rheumatoid arthritis (RA). Arsenic trioxide (ATO, As 2 O 3 ) has been reported to inhibit synovial angiogenesis via vascular endothelial growth factor (VEGF)-centered functional module. However, exact mechanisms ATO on VEGF modulation remain unclear. Circular RNAs (circRNAs) are emerging as important regulators RA, and detailed largely unknown. Here, we circRNA (circHIPK3), expression which was significantly increased RA fibroblast-like...
The role of circular RNAs (circRNAs) in rheumatoid arthritis (RA) remains to be elucidated. To determine the expression circRNAs peripheral blood mononuclear cells (PBMCs) and identify novel biomarkers for RA explore their potential effects RA, present study conducted high‑throughput RNA sequencing analyze circRNA profiles PBMCs from 4 patients 3 healthy controls (HCs). Reverse transcription‑quantitative PCR was used verify circPTPN22 42 patients, 44 HCs 45 systemic lupus erythematosus (SLE)...
Abstract Background Accumulating studies have shown that La‐related protein 1 (LARP1) is involved in the occurrence and development of various tumours. However, expression pattern biological role LARP1 hepatoblastoma (HB) remain unclear so far. Methods level HB adjacent normal liver tissues was analysed by qRT‐PCR, Western blotting immunohistochemistry assays. The prognostic significance evaluated Kaplan–Meier method multivariate Cox regression analysis. In vitro vivo functional assays were...
Background: Postoperative cognitive dysfunction (POCD) is one of the severe complications inducing low life quality and high mortality after surgery, especially in elderly patients. However, underlying molecular mechanism POCD remains largely unknown ideal biomarker for clinical diagnosis prognosis lacking. Circular RNAs (circRNAs), as a unique class noncoding (ncRNAs), was characterized by its stably conservativeness serving novel biomarkers various disease. Nevertheless, role circRNAs...
This study proposes a bluff body non-rotational galloping-based piezoelectric wind energy harvester (BNRGH) for overall output performance enhancement. The used in this structure is designed to be available rotate with respect the free end of two cantilever beams by connection rotatable hinges. A series comparisons are conducted experimentally tunnel between proposed and conventional harvester, which commonly configured single beam. results show that capable preventing variation attack angle...
Gastric cancer is a common malignant tumor worldwide. N-methyl-N-nitro-N-nitroguanidine (MNNG) one of the most important inducing factors gastric cancer. Autophagy can affect occurrence and development cancer, but mechanism not clear. Chemoprevention has been shown to be rational very promising approach prevention Hesperidin citrus flavone, an abundant polyphenol in fruits traditional Chinese medicine. It excellent phytochemistry that plays intervention role However, it unclear whether...
Breast cancer is the most common type of worldwide. There are great challenges in prevention and treatment breast cancer. In this study, we explored molecular biological mechanisms circular RNA circEPSTI1 (has_circ_0000479) regulation HER2-positive cells. The expression CircEPSTI1, microRNA miR-145, ERBB3 cells was evaluated by qRT-PCR western blot assays. Cell proliferation assessed CCK-8. Wound-healing transwell migration assays were performed to evaluate cell migration. A invasion assay...
The incidence and mortality of colorectal cancer (CRC) are ranked in the top three worldwide 2020. Abundant studies have reported that circular RNAs (circRNAs) act critical roles genesis development tumors, including CRC. Nevertheless, detailed regulation mechanisms circRNAs related to initiation CRC not been fully found clarified. This research primarily revealed circTMEM59 was greatly downregulated tissues cell lines via qRT-PCR. In addition, decreased expression closely adverse...
Gastric cancer (GC) is a malignant with the highest global rates of morbidity and death. Dietary factors have close relationship occurrence GC. Circular RNAs (circRNAs) N6-methyladenine (m6A) are important in onset progression GC other malignancies. However, little known about role circRNA m6A modifications development Initially, transformed cell model generated by chemical carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) was established this investigation. Furthermore, following...