Abstract Background Metastasis of breast cancer have caused the majority cancer-related death worldwide. The circRNAs are associated with tumorigenesis and metastasis in according to recent research. However, biological mechanism liver metastatic remains ambiguous yet. Methods Microarray analysis three pairs primary BC tissues matched hepatic specimens identified circEZH2. We used RT-qPCR FISH assays confirm circEZH2 existence, characteristics, expression. Both vivo vitro, played an...

Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are associated with carcinogenesis and metastasis many cancers. Nevertheless, biological mechanisms in breast cancer (BC) liver remain extremely ambiguous.In this study, we identified circROBO1 from three pairs primary BC metastatic sites by RNA sequencing. FISH assays RT-qPCR were conducted to validate existence expression circROBO1. The oncogenic role was demonstrated both...

Circular RNAs (circRNAs) is one kind of non-coding (ncRNAs) and exert crucial functions in biological processes intracellular gene expression modulation. However, the roles status majority circRNAs still remain unknown cervical cancer.In this study, circEPSTI1 (hsa_circRNA_000479) was significantly upregulated cancer. We first discovered impact circRNA on cell ferroptosis Interestingly, attenuates effect ferritin which mediated by SLC7A11 based lipid peroxidation measurements reduced...

Abstract Aim Pyroptosis is a type of programmed cell death characterized by pro‐inflammatory activity and an important factor in pre‐eclampsia (PE). Trimethylamine N‐oxide (TMAO) gut microbial metabolite closely associated with pyroptosis PE. This study aims to investigate the role TMAO trophoblast explore possible mechanisms. Methods Western blot qRT‐polymerase chain reaction (PCR) were used detect expression levels ten‐eleven translocation 2 (TET2), cytochrome b (CYTB), pyroptosis‐related...

Abstract Background/Aims RNA N6-methyladenosine (m6A) modification is widely implicated in immune and inflammatory regulation. However, it remains unclear whether m6A involved the regulation of phenotype M1 macrophages rheumatoid arthritis (RA) its clinical significance. Methods RNA-Seq was conducted on PBMCs-induced from healthy donors RA patients. The methylation status patients individuals detected using dot-blot analysis. were treated with 50 µM 3-deazadenosine, macrophage proliferation...

A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in syngeneic mouse model breast and colon carcinoma. The H-RT L-TBI potentially enhanced by infiltration CD8 + T cell altering immunosuppressive microenvironment...

We assessed the efficacy and safety of nimotuzumab plus neoadjuvant chemotherapy followed by concurrent chemoradiotherapy for Chinese patients with locoregionally advanced nasopharyngeal carcinoma. Clinical data from 210 nonmetastatic carcinoma diagnosed between May 2008 April 2014 were retrospectively reviewed. All initially treated chemoradiotherapy. Ninety-five received cisplatin-based adjuvant chemotherapy. The median follow-up duration was 48 months. Locoregional relapse distant...

Addition of induction chemotherapy (IC) to concurrent chemoradiotherapy (CC) is an encouraging first-line treatment strategy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We evaluated the clinical efficacy and toxicity addition gemcitabine plus cisplatin (GP) IC intensity-modulated radiotherapy (IMRT) CC NPC. At a median follow-up duration 48 months (10-59 months), 4-year local relapse-free survival (LRFS) was 86.9%, regional (RRFS) 90.6%, distant metastasis-free...

This study was conducted to assess the efficacy and safety of nimotuzumab combined with radiotherapy (RT) in elderly patients nasopharyngeal carcinoma.

// Wang Fangzheng 1, 2, 3, * , Jiang Chuner 4, Lei 2 Yan Fengqin Ye Zhimin Sun Quanquan Liu Tongxin Xu Min 5 Wu Peng 6 Long Bin 7 Rihito Aizawa 8 Masoto Sakamoto 3 and Fu Zhenfu 1 Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, People’s Republic China Key Laboratory Radiology, Japanese Red Cross Fukui Fukui, 918-8501 Japan 4 Breast Tumor Surgery, Physics, Pathology, Nuclear Medicine, Oncology Image-applied Therapy, Graduate School Kyoto University,...

CircRNAs (circRNAs) are a kind of non-coding RNAs which extensively distributed in tissues. Previous investigations reported that circRNAs harbor indispensable roles modulating the progress multiple cancers. Nevertheless, function along with molecular mechanism most cervical cancer progression was still not clear. Herein, we illustrated circEPSTI1 is remarkably upregulated circRNA, validated tissues cell lines. The biological role advancement probed via loss-of assessments. Silencing could...

Purpose: To determine whether postoperative radioiodine (RAI) combined with radiofrequency ablation (RFA) is an effective, safe, and feasible method for elimination of excessive postsurgical thyroid remnant differentiated carcinoma (DTC). Materials Methods: We took a prospective study treated 12 DTC patients (4 males, 8 females, age 20–78 years) who underwent thyroidectomy RFA followed by 131I ablation. The pretreatment requires iodine-free diet hormone withdrawal 3–4 week. All the showed...

// Wang Fangzheng 1, 2, 3, * , Jiang Chuner 4, Ye Zhimin 2 Sun Quanquan Liu Tongxin Xu Min 5 Wu Peng 6 Long Bin 7 Masoto Sakamoto 3 Yuezhen Yan Fengqin Fu Zhenfu and Yangming 8 1 Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, People’s Republic China Key Laboratory Radiology, Japanese Red Cross Fukui 918-8501, Japan 4 Breast Tumor Surgery, Physics, Pathology, Nuclear Medicine, Didital Earth, Institute Remote Sensing CAS, Beijing 100101, These authors have...

Aim: Tumor cell-derived microparticles (MP) can function as a targeted delivery carrier for anti-tumor drugs. Here, we aimed to generate paclitaxel-loaded (MP-PTX) from HeLa cells and examined its therapeutic potential on human cervical carcinoma. Methods: MP-PTX was generated by ultraviolet radiation subsequent centrifugation. The particle size, drug loading rate, stability of were in vitro. Flow cytometry the MTT assay performed test inhibitory effect using different cell lines....

In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two NPC were enrolled between May 2008 and April 2014 received radical IMRT simultaneous integrated boost technique using 6 MV photons; some patient groups also every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months all patients. At the last...

This study aimed to investigate the efficacy and safety of using metronomic S-1 adjuvant chemotherapy in locoregionally advanced nasopharyngeal carcinoma (LANPC).

Although induction chemotherapy (IC) combined with intensity-modulated radiotherapy (IMRT) plus concurrent (CC) is the new standard treatment option in locoregionally advanced nasopharyngeal carcinoma (NPC), many patients fail to receive CC. The aim of this study was investigate long-term survival outcomes and toxicities these who are treated IC before IMRT without CC.We retrospectively reviewed 332 untreated, newly diagnosed NPC received alone at our institution from May 2008 through April...

Autophagy, the process responsible for degrading cytoplasmic organelles to sustain cellular metabolism, has been associated with cancer initiation and progression. As TP53-induced glycolysis apoptosis regulator (TIGAR) is among important genes that can regulate autophagy, we aimed investigate correlation between expression levels of TIGAR autophagy-related protein microtubule-associated 1 light chain 3 (LC3B), as well their association clinical outcomes, in nasopharyngeal carcinoma (NPC)...

// Wang Fangzheng 1, 2, * , Jiang Chuner 3, Sun Quanquan 2 Ye Zhimin Liu Tongxin Jiping 4 Masoto Sakamoto 5 Wu Peng 6 Shi Kaiyuan 7 Qin Weifeng Fu Zhenfu and Yangming 8 1 Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, People’s Republic China Key Laboratory Oncology Province, 3 Breast Surgery, Physics, Radiology, Fukui Red Cross 918-8501, Japan Pathology, Ultrasonography, Digital Earth, Institute Remote Sensing CAS, Beijing 100101, These authors have...

Background: CircRNA plays an important role in cancer progression.However, the potential mechanism of circRNA gastric remains unknown.In this study, we aimed to investigate specific circALPL cancer.Methods: Using a high-throughput microarray, found that was upregulated cell lines.RT-qPCR used measure expression level lines and tissue.Transwell, CCK-8, metastasis assays were performed learn function after inhibited.Results: downregulation suppresses invasion proliferation ability...