A5100330845- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Biosensors and Analytical Detection
- Cytokine Signaling Pathways and Interactions
- Nitric Oxide and Endothelin Effects
- Bone Metabolism and Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- S100 Proteins and Annexins
- RNA Research and Splicing
- Rheumatoid Arthritis Research and Therapies
- Nuclear Receptors and Signaling
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Reproductive System and Pregnancy
- Nuclear Structure and Function
- Gene expression and cancer classification
Ningbo University
2023-2025
Sun Yat-sen University
2022-2025
Fuzhou University
2021-2025
Fujian Provincial Hospital
2023-2025
Fujian Medical University
2023-2025
Hebei General Hospital
2025
Third Affiliated Hospital of Sun Yat-sen University
2022-2025
Yanbian University
2023-2024
Yixing Tumor Hospital
2024
China Medical University
2019-2024
Early diagnosis of cancers relies on the sensitive detection specific biomarkers, but most current testing methods are inaccessible to home healthcare due cumbersome steps, prolonged time, and utilization toxic hazardous substances. Herein, we developed a portable self-powered photoelectrochemical (PEC) sensing platform for rapid prostate-specific antigen (PSA, as model disease-related protein) by integrating photoelectric signal output system catalyzed with chemiluminescence-functionalized...
Photoelectrochemical (PEC) biosensors incorporating biomolecular recognition with photon-to-electron conversion capabilities of the photoactive species have been developed for molecular diagnosis, but most involve difficulty in adjusting band gap positions and are unsuitable PEC biodetection. In this work, an innovative biosensor combined quantum size-controlled engineering based on confinement by controlling size was designed detection human papillomavirus-16 (HPV-16) through CRISPR-Cas12a...
Circular RNAs (circRNAs) is one kind of non-coding (ncRNAs) and exert crucial functions in biological processes intracellular gene expression modulation. However, the roles status majority circRNAs still remain unknown cervical cancer.In this study, circEPSTI1 (hsa_circRNA_000479) was significantly upregulated cancer. We first discovered impact circRNA on cell ferroptosis Interestingly, attenuates effect ferritin which mediated by SLC7A11 based lipid peroxidation measurements reduced...
Photoelectrochemical immunoassays incorporating specific antigen-antibody recognition reactions with the photon-electron conversion capabilities of photocatalysts have been developed for biomarker detection, but most involve bulky and expensive equipment are unsuitable point-of-care testing. Herein, a portable smartphone-based photoelectrochemical immunoassay was innovatively designed on-site detection breast cancer biomarkers (human epidermal growth factor receptor 2; HER2). The system...
Gastric cancer (GC) is a common malignant tumor of the digestive tract, and chemoresistance significantly impacts GC patients' prognosis. PANoptosis has been associated with oxaliplatin-induced cell death. However, direct regulatory role YBX1 in cellular through remains unclear. In this study, we investigated impact on regulating its influence resistance gastric cells to oxaliplatin. Through overexpression silencing experiments, assessed YBX1's effect proliferation regulation cells....
This work reports a photoelectrochemical (PEC) biosensing platform for the sensitive and specific screening of thrombin by using graphene oxide-coated copper-doped zinc oxide quantum dots (Cu0.3Zn0.7O-GO QDs) as photoactive materials glucose oxidase-encapsulated DNA nanoflowers (GOx-DFs) signal amplification. Interestingly, coated nanosheets on surface Cu0.3Zn0.7O QDs could cause charge to transfer rapidly ameliorate photocorrosion. The doped copper into enhance absorption visible light...
WRKY proteins play important regulatory roles in plant developmental processes such as senescence, trichome initiation and embryo morphogenesis. In strawberry, only FaWRKY1 (Fragaria × ananassa) has been characterized, leaving numerous genes to be identified their function characterized. The publication of the draft genome sequence strawberry allowed us conduct a genome-wide search for Fragaria vesca, compare with homologs model plants. Fifty-nine FvWRKY were annotated from F. vesca genome....
Herein, an in situ amplified photoelectrochemical (PEC) immunoassay with ZnO microflowers (ZnO MFs) decorated gold nanoparticles (Au NPs) was developed to determine human prostate-specific antigen (PSA) using l-cysteine-loaded liposomes for signal amplification. Initially, MFs smooth and well-defined morphology were synthesized under hydrothermal conditions. The heterostructured formed by depositing Au NPs on trisodium citrate. l-Cysteine (l-Cys)-encapsulated conjugated detection antibodies...
Cancer nanovaccines have emerged as an indispensable weapon for tumor treatment. However, insufficient immunogenicity and immunosuppression hamper the therapeutic effects of nanovaccines. Here, biodegradable (OMPP) composed ovalbumin (OVA)-manganese oxide nanoparticles, amphiphilic poly(γ-glutamic acid) (γ-PGA), ε-polylysine (PL) are constructed to realize enhanced cancer immunotherapy. Interestingly, γ-PGA PL could serve both carriers immunoadjuvants promote cytosolic delivery antigens...
Objective: Gastric cancer is one of the most common malignant tumors in world.IGHG1 a differentially expressed protein screened out gastric early stage subject group.This topic explores expression IGHG1 and effect on proliferation, migration, invasion EMT SGC7901 cells its mechanism action.Methods: Twenty cases were purified by laser Capture Microdissection.The isotopic tags for relative absolute quantification was used to label proteins, then analyzed identified them quantitative...
Dictyophora indusiata, commonly known as bamboo fungus, is a type of edible mushroom that highly popular worldwide for its rich flavor and nutritional value. It also recognized pharmaceutical efficacy, with medicinal benefits attributed to consumption. One the most important components indusiata polysaccharide, which has been acknowledged promising regulator biological response due immunostimulatory anti-inflammatory properties. However, specific roles polysaccharide in modulating NOD-like...
Coxsackievirus B (CVB) is one of the major viral pathogens human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it necessary to develop a safe efficacious vaccine against CVB. Immunoinformatics methods are both economical convenient as in-silico simulations can shorten development time. Herein, we design novel multi-epitope for prevention CVB by using immunoinformatics methods. With help advanced approaches, predicted different B-cell, cytotoxic T...
Abstract This study utilized data from 140,294 prostate cancer cases the Surveillance, Epidemiology, and End Results (SEER) database. Here, 10 different machine learning algorithms were applied to develop treatment options for predicting patients with cancer, differentiating between surgical non‐surgical treatments. The performances of measured using area under receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, positive predictive value, negative value....
Rotated object detection has made significant progress in the optical remote sensing. However, advancements Synthetic Aperture Radar (SAR) field are laggard behind, primarily due to absence of a large-scale dataset. Annotating such dataset is inefficient and costly. A promising solution employ weakly supervised model (e.g., trained with available horizontal boxes only) generate pseudo-rotated for reference before manual calibration. Unfortunately, existing models exhibit limited accuracy...
Objectives The prognostic value of thyroglobulin antibody (TgAb) and its trends during follow-up periods may guide the treatment plans in patients with differentiated thyroid cancer (DTC) following surgery, however, there is still a lack sufficient data. This study aims to evaluate impact change TgAb levels on prognosis DTC explore potential application clinical practice. Materials methods A retrospective analysis was conducted medical records 2,981 who underwent surgery followed by 131 I...
<title>Abstract</title> TM9SF1, a transmembrane protein, has been linked to several cancers, but its role in oncology remains understudied. This study employed machine learning, TCGA, GTEx, and UALCAN databases investigate TM9SF1 expression across various cancers. Prognostic value was assessed using Cox regression Kaplan–Meier methods. Further analyses explored mutations, methylation, immune infiltration, drug sensitivity. Results revealed that significantly elevated multiple tumors...
Abstract Circular RNAs (circRNAs) are crucial regulators of targeted drug resistance in hepatocellular carcinoma (HCC). However, the specific mechanisms underlying that significantly hampers effectiveness HCC treatments remain unclear. Here, it is found circRNA‐mTOR highly expressed and strongly correlated with patient prognosis. Furthermore, enhances stemness cells, thereby promoting progression contributing to lenvatinib resistance. Mechanistically, promotes nuclear translocation...