A5013299897- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced Nanomaterials in Catalysis
- Network Security and Intrusion Detection
- Advancements in Battery Materials
- Advanced Proteomics Techniques and Applications
- DNA Repair Mechanisms
- Advanced Battery Materials and Technologies
- Cancer Research and Treatments
- Crystallization and Solubility Studies
- Cancer-related Molecular Pathways
- Advanced Malware Detection Techniques
- Ferroptosis and cancer prognosis
- Metabolomics and Mass Spectrometry Studies
- Internet Traffic Analysis and Secure E-voting
- S100 Proteins and Annexins
- Microtubule and mitosis dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Ubiquitin and proteasome pathways
- X-ray Diffraction in Crystallography
- Anomaly Detection Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Hepatitis B Virus Studies
- Nanocluster Synthesis and Applications
University of Pittsburgh
2016-2025
Hunan University of Technology
2023-2025
Fujian Normal University
2022-2025
Wenzhou University
2023-2025
Zunyi Medical University
2024
Yantai University
2024
Harbin Engineering University
2024
Hunan Normal University
2018-2024
Hunan Provincial People's Hospital
2024
Children's Hospital of Pittsburgh
2024
Abstract Synergistic phototherapy has the potential to conquer extreme heterogeneity and complexity of difficult tumors result in better cancer treatment outcomes than monomodal photodynamic therapy (PDT) or photothermal (PTT). However, previous approaches combining PDT PTT are mainly focused on primary tumor obliteration while neglecting metastasis, which is responsible for about 90% deaths. It shown that a combined PDT/PTT approach, based upconversion‐polymer hybrid nanoparticles with...
Cuproptosis is dependent on mitochondrial respiration modulation by targeting lipoylated tricarboxylic acid cycle (TCA) proteins, showing great potential in cancer treatment. However, the specific release of copper ions at highly needed and still a major challenge to trigger cellular cuproptosis. Herein, metal-organic framework-based nanoplatform (ZCProP) designed for mitochondrial-targeted ATP/pH-responsive Cu
Patients with Alzheimer's disease (AD) little or no quantifiable insoluble brain tau neurofibrillary tangle (NFT) pathology demonstrate stronger clinical benefits of therapies than those advanced NFTs. The formation NFTs can be prevented by targeting the intermediate soluble assemblies (STAs). However, biochemical understanding and biomarkers STAs are lacking. We show that Tris-buffered saline-soluble aggregates from autopsy-verified AD tissues include core sequence ~tau258-368. In...
Heart attack is a global health problem that leads to significant morbidity, mortality, and care burden. Adult human hearts have very limited regenerative capability after injury. However, evolutionarily primitive species generally higher capacity than mammals. The extracellular matrix (ECM) may contribute this difference. Mammalian cardiac ECM not be optimally inductive for regeneration because of the fibrotic, instead regenerative, responses in injured adult mammalian hearts. Given high...
Ubiquitination mediates endocytosis and endosomal sorting of various signaling receptors, transporters, channels. However, the relative importance mono- versus polyubiquitination role specific types polyubiquitin linkages in endocytic trafficking remain controversial. We used mass spectrometry-based targeted proteomics to show that activated epidermal growth factor receptor (EGFR) is ubiquitinated by one two short (two three ubiquitins) chains mainly linked via lysine 63 (K63) or conjugated...
Recent large-scale genetic sequencing efforts have identified rare coding variants in genes the triglyceride-rich lipoprotein (TRL) clearance pathway that are protective against coronary heart disease (CHD), independently of LDL cholesterol (LDL-C) levels. Insight into mechanisms protection these may facilitate development new therapies for lowering TRL The gene APOC3 encodes apoC-III, a critical inhibitor triglyceride (TG) lipolysis and remnant clearance. Here we report detailed...
Abstract The colon tumor microenvironment has a high concentration of H 2 S and glutathione, which is highly immunosuppressive adverse to multiple therapeutic methodologies such as ferroptosis. Here, an engineered microbial nanohybrid based on Escherichia coli ( E. ) Cu O nanoparticles specific therapy immunosuppression reversion reported. as‐prepared @Cu hybrid can accumulate in sites upon intravenous injection, convert x by consuming the endogenous S, exhibits strong photothermal...
This paper established hybrid prediction models based on variational mode decomposition (VMD), empirical (EMD), and ensemble (EEMD) combined with the backpropagation neural network model (BPNN) to improve accuracy of reference crop evapotranspiration (ET0) time series characteristics nonlinearity instability. The daily ET0 data 11 representative stations in Xinjiang from 1993 2016 were selected for training testing compared results support vector regression (SVR) gradient boosting tree...
To meet the ever-increasing demand for high-energy lithium-ion batteries (LIBs), it is imperative to develop next-generation anode materials. Compared conventional carbon-based anodes, Si-based materials are promising due their high theoretical capacity and reasonable cost. SiO
Abstract Development of ferroptosis-inducible nanoplatforms with high efficiency and specificity is highly needed challenging in tumor ferrotherapy. Here, we demonstrate effective ferrotherapy using iron (II)-based metal-organic framework (Fe ss MOF) nanoparticles, assembled from disulfide bonds ferrous ions. The as-prepared Fe MOF nanoparticles exhibit peroxidase-like activity pH/glutathione-dependent degradability, which enables tumor-responsive catalytic therapy glutathione depletion by...
Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death subsequent antitumor immune responses. However, dysregulated metabolism in cells maintains homeostatic balance, while hypoxic microenvironments hinder therapeutic efficacy. In this study, we present a nanozyme system, termed CussOMEp, comprising copper-based nanovector (CussNV) that is PEGylated loaded with omeprazole, transporter inhibitor, enhance synergistic immunotherapy by promoting...
We have identified a novel centromere-associated gene product from Saccharomyces cerevisiae that plays role in spindle assembly and stability. Strains with deletion of SLK19 (synthetic lethal Kar3p gene) exhibit abnormally short mitotic spindles, increased numbers astral microtubules, require the presence kinesin motor for viability. When cells are deprived both Slk19p Kar3p, rapid breakdown arrest is observed. A functional fusion to green fluorescent protein (GFP) localizes kinetochores...
Targeted glycoproteomics represents an attractive approach for conducting peripheral blood based cancer biomarker discovery due to the well-known altered pattern of protein glycosylation in and reduced complexity resultant glycoproteome. Here we report its application a set pooled nonsmall cell lung (NSCLC) case sera (9 adenocarcinoma 6 squamous carcinoma pools from 54 patients) matched controls pools, including 8 clinical control with computed tomography detected nodules but being...
Abstract Biomimetic mineralization of live organisms shows extraordinary promise in biotechnology. However, their therapeutic applications have been insufficiently explored. Herein, it is demonstrated that metal–organic framework (MOF)‐engineered bacteria are powerful carriers for tumor‐targeted delivery. Specifically, Escherichia coli (MG1655) coated with a zeolitic imidazolate framework‐8 layer coloaded photosensitizer and chemical drug through one‐step situ method. The as‐prepared...