Disruption of disulfide homeostasis during biological processes can have fatal consequences. Excess disulfides induce cell death in a novel manner, termed as "disulfidptosis." However, the specific mechanism disulfidptosis has not yet been elucidated. To determine cancer types sensitive to and outline corresponding treatment strategies, we firstly investigated crucial functions regulators pan-cancer at multi-omics levels. We found that different tumor expressed dysregulated levels...

Lung cancer is the leading cause of death world-wide and its treatment remains a challenge in clinic, especially for non-small cell lung (NSCLC). Thus, more effective therapeutic strategies are required NSCLC treatment. Quercetin (Que) as natural flavonoid compound has gained increasing interests due to anticancer activity. However, poor water solubility, low bioavailability, short half-life, weak tumor accumulation hinder vivo applications antitumor effects Que. In this study, we developed...

Immunotherapy has emerged as a promising therapeutic strategy for cancer therapy. However, the efficacy been distracted due to poor immunogenicity and immunosuppressive tumor microenvironment. In this study, self-augmented reactive oxygen species (ROS) responsive nanocarrier with immunogenic inducer paclitaxel (PTX) indoleamine 2,3-dixoygenase 1 (IDO1) blocker 1-methyl-D, L-tryptophan (1-MT) co-entrapment was developed rejection. The carrier composed of poly (ethylene glycol) (PEG)...

Lung cancer was often accompanied by depression and anxiety. Nowadays, most investigations for anxiety were concentrated in western medical hospitals, while few related studies have been carried out the tradition Chinese medicine (TCM) ward. It necessary to understand proportion factors of inpatients with lung TCM hospital.This study adopted cross-sectional research method, which enrolled a total 222 hospital. PHQ-9 GAD-7 scales used assess inpatients, respectively. Demographic clinical data...

Triple negative breast cancer (TNBC) is one of the most aggressive tumors with high metastasis and mortality, which constitutes 15~20% all cancers. Chemotherapy remains main therapeutic option in treatment patients TNBC.We developed reactive oxygen species (ROS)-responsive galactosylated nanoparticles (DOX@NPs) as an efficiently targeted carrier for doxorubicin (DOX) delivery to inhibit growth TNBC vitro vivo. DOX@NPs were composed polyacrylate galactose phenylboronic derivatives...

Insomnia is increasingly emerging as a significant concern in public health, with longstanding emphasis on its relationship overall well-being. Nevertheless, few research has been devoted to investigating the between insomnia and female reproductive health. In our study, we conducted Mendelian randomization (MR) study estimate causal diseases. A total of 268 independent genetic variants associated at genome-wide significance level (P < 5×10-8) were used instrumental variables. Summary-level...

This study aims to develop optimal predictive models for perioperative neurocognitive disorders (PND) in hip arthroplasty patients, thereby advancing clinical practice. Data from all patients the MIMIC-IV database were utilized predict PND. With 62 variables, we applied multiple logistic regression, artificial neural network (ANN), Naive Bayes, support vector machine, and decision tree (XgBoost) algorithms forecast Feature analysis, receiver operating characteristic curve (ROC) calibration...

The purpose of this study is to determine the incidence and severity symptoms patients with cervical cancer within 6 months after radiotherapy chemotherapy, form a symptom burden report, evaluate distribution characteristics symptoms, identify clusters, provide basis for clinical doctors nurses improve management chemotherapy.The chemotherapy were recruited investigate their burden. Exploratory factor analysis was used clusters.A total 250 participated in study. found that most common among...

Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment IS are unclear, then we carried out this study. 52 incoming blood components were resolved by UHPLC-MS/MS from rat serum, including 45 prototype components. The potential active hydroxysafflor yellow A, ginsenoside F1, quercetin, ferulic acid caffeic screened network pharmacology showed strongly binding...

Breast cancer is the most common type of worldwide. There are great challenges in prevention and treatment breast cancer. In this study, we explored molecular biological mechanisms circular RNA circEPSTI1 (has_circ_0000479) regulation HER2-positive cells. The expression CircEPSTI1, microRNA miR-145, ERBB3 cells was evaluated by qRT-PCR western blot assays. Cell proliferation assessed CCK-8. Wound-healing transwell migration assays were performed to evaluate cell migration. A invasion assay...

Osteosarcoma (OS) is the most prevalent human bone malignancy, and presents a global annual morbidity of approximately five cases per million. Notably, precise efficient targeted therapy has become promising strategy for treatment OS; however, there still an urgent need identification suitable therapeutic targets. Metastasis-associated in colon cancer 1 (MACC1) was first identified tumors by differential display RT-PCR, shown to be involved regulation tumor growth metastasis through...

Background. Cancer-related fatigue (CRF) is an increasingly appreciated complication in cancer patients, which severely impairs their quality of life for a long time. Astragali Radix (AR) safe and effective treatment to improve CRF, but the related mechanistic studies are still limited. Objective. To systematically analyze mechanism AR against CRF by network pharmacology. Methods. TCMSP was searched obtain active compounds targets AR. The compound-target (AC-T) established exhibited...

The efficacy of chemotherapy is often reduced due to the resistance tumor cells, which usually caused by abnormal gene overexpression. Herein, multifunctional nanocomplexes (Que/siBCL2@BioMICs) were developed deliver quercetin (Que) and BCL-2 siRNA (siBCL2) synergistically inhibit growth. composed an amphiphilic triblock copolymer poly(ethylene glycol) methyl ether methacrylate-poly[2-(dimethylamino) ethyl acrylate]-polycaprolactone (PEGMA-PDMAEA-PCL)...

Obesity has been reported to be a risk factor for breast cancer, but how obesity affects cancer (BC) remains unclear. Although body mass index (BMI) is the most commonly used reference obesity, it insufficient evaluate obesity-related pathophysiological changes in tissue. The purpose of this study establish DNA-methylation-based biomarker BMI (DM-BMI) and explore connection between BC. Using DNA methylation data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), we developed...

Two-pore domains potassium channel subunits, encoded by KCNK genes, play vital roles in breast cancer progression. However, the characteristics of most genes has yet to be clarified. In this study, we comprehensively analyzed expression, alteration, prognosis, and biological functions various KCNKs cancer. The expression KCNK1/4/6/9/10/13 were significantly upregulated, while KCNK2/3/5/7/17 downregulated tissues compared normal mammary tissues. Increased KCNK1/3/4/9 was correlated with poor...

Long noncoding RNAs (lncRNAs) play important roles in the regulation of immunological and apoptotic function. This study aimed to explore critical immune- apoptosis-related lncRNAs occurrence development Henoch-Schönlein purpura nephritis (HSPN) children.Differential analysis was employed identify differentially expressed lncRNAs, as well mRNAs children with HSPN. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses were used validate mRNAs. Spearman's correlation...

Background: Matrix metalloproteinase 14 (MMP14) has been reported to be upregulated in some types of cancer and promote cell invasion metastasis.However, the expression profile functional role MMP14 kidney renal clear carcinoma (KIRC) remains unknown.This study investigated association between level prognosis KIRC. Methods:The messenger RNA (mRNA) clinical data (including T stage, N M pathologic gender, race, age, histologic grade, serum calcium, hemoglobin) were obtained fromThe Cancer...

Circular RNAs (circRNAs) have played an essential role in cancer development. This study aimed to illustrate the impact and potential mechanism of circRACGAP1 action NSCLC The expression patterns circRACGAP1, miR-1296, CDK2 tissues cell lines were analysed by RT-qPCR. function proliferation apoptosis was investigated using CCK-8 assay, flow cytometry, TUNEL staining, Western blot. interaction among clarified dual-luciferase reporter assay while correlation confirmed Pearson coefficient....