A5041807094- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- RNA modifications and cancer
- Advanced Glycation End Products research
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Microbial Metabolism and Applications
- Gastroesophageal reflux and treatments
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
- Acute Ischemic Stroke Management
- Phytochemistry and Bioactivity Studies
- Multiple Sclerosis Research Studies
- Heat shock proteins research
- Drug-Induced Hepatotoxicity and Protection
- Genetic Associations and Epidemiology
- Cholesterol and Lipid Metabolism
- Endoplasmic Reticulum Stress and Disease
Guangzhou University of Chinese Medicine
2013-2025
Shenzhen Pingle Orthopedic Hospital
2017-2024
Third Affiliated Hospital of Sun Yat-sen University
2016
Sun Yat-sen University
2016
Guangzhou University
2006
The heat shock protein 90 (HSP90s) family is composed of molecular chaperones four isoforms in humans, which has been widely reported as unregulated various kinds cancers. Nevertheless, the role each HSP90s isoform prognosis and immune infiltration distinct subtypes breast cancer (BRAC) remains unclear.Public online databases including Oncomine, UALCAN, Kaplan-Meier Plotter, Tumor IMmune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis (GEPIA), GeneMANIA, Database...
Background: High mobility group box (HMGB) proteins are DNA chaperones involved in transcription, repair, and genome stability. Extracellular HMGBs also act as cytokines to promote inflammatory immune responses. Accumulating evidence has suggested that implicated cancer pathogenesis; however, their prognostic immunological values pan-cancer not completely clear. Methods: Multiple tools were applied analyze the expression, genetic alternations, clinicopathological relevance of HMGB...
Compound Phyllanthus urinaria L (CP) is a traditional formula widely used in clinical practice for hepatocellular carcinoma (HCC), especially HBV-related HCC. HBx, HBV X gene encoded protein, has positive correlation with the abnormal SHH pathway So, we predicted that CP capability of anti-HBV-related HCC maybe via inactivating HBx-Hedgehog axis. HepG2-HBx cells, HBx overexpression, were treated (70 μ g/ml and 35 g/ml, respectively) 48 hours mice which received cells (625mg/kg 300 mg/kg, 17...
Background: Aberrant expression of NEU1 has been identified in many malignancies. Nevertheless, the clinical significance hepatocellular carcinoma (HCC) not fully elucidated. Methods: In our study, multiple databases, including ONCOMINE, The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), International Consortium (ICGC), Cell Line Encyclopedia (CCLE), Human Protein (HPA), Kaplan-Meier (KM) plotter, MethSurv, Profiling Interactive Analysis (GEPIA), and Metascape, etc., were...
<b><i>Objective:</i></b> To investigate the relationship between neuromyelitis optica spectrum disorder (NMOSD) and autoantibodies. <b><i>Methods:</i></b> Blood samples of 108 NMOSD patients 38 controls were collected from January 2012 to August 2014. Immunological parameters, including anti-aquaporin 4, antinuclear, anti-ribonucleoprotein, anti-SM, anti-SSA/Ro, anti-SSB/La anti-ribosomal P-protein autoantibodies examined....
The prognosis of patients with advanced hepatocellular carcinoma (HCC) is still poor, effective therapeutic targets are needed. ZW10 interacting kinetochore protein (Zwint) an essential component the mitotic spindle checkpoint and upregulated in cancers. Disappointing, role ZWINT HCC has not been fully illuminated.Multiple tools, including TIMER2.0, Oncomine, GEPIA2, UALCAN, LinkedOmics, Kaplan-Meier Plotter, cBioPortal, MethSurv, etc. were applied to comprehensively analyze expression,...
Liver metastasis (LM) stands as a primary cause of mortality in metastatic colorectal cancer (mCRC), posing significant impediment to long-term survival benefits from targeted therapy and immunotherapy. However, there is currently lack comprehensive investigation into how senescent exhausted immune cells contribute LM.
Objective . In this study, the data mining method was used to screen core Chinese materia medicas (CCMMs) against primary liver cancer (PLC), and potential mechanisms of CCMMs in treating PLC were analyzed based on network pharmacology. Methods Traditional medicine (TCM) prescriptions for obtained from a famous TCM doctor Shenzhen, China. According technique, Inheritance Support System (TCMISS) applied excavate prescriptions. Then, bioactive ingredients corresponding targets collected using...
The aim of this paper is to identify the differentially expressed lncRNAs (DELs) that could serve as markers for prognosis early-stage (stage I-II) lung squamous cell carcinoma (SCC).lncRNAs expression data and corresponding clinical information 395 patients with stage I-II SCC were obtained from Cancer Genome Atlas (TCGA). Univariate Cox regression analysis LASSO used screen key lncRNAs, which then subjected a multivariate analysis. Furthermore, based on results analysis, statistical...
A Chinese Herbal Formula (CHF) has acquired a certain therapeutic effect on chronic HBV infection. To assess the efficacy and safety of CHF replication in carriers, we performed randomized, double-blind, placebo-controlled trial involving patients from 16 centers. total 300 confirmed carriers were randomized at baseline ratio 2 : 1 to receive either or placebo for 52 weeks. The results showed that greater proportion than treated achieved virological response week 52; mean decline serum HBsAg...
Nonalcoholic fatty liver disease (NAFLD) is a rising global public health concern due to its prevalence. Danning Tablets (DNt), composite prescription of Chinese herbal medicine, shows significant curative effects on NAFLD in clinical application. This study aimed decipher the bioactive substances and potential mechanisms action DNt treatment NAFLD, applying an integrated network pharmacology approach. First, compounds were screened based their pharmacokinetic properties, corresponding drug...
Objective . Chinese herbs play a positive role in the management of hepatocellular carcinoma (HCC) China. However, it is not clear which are critical for treatment HCC. Besides, mechanisms CCHs HCC remain unclear. Hence, our goal to identify core (CCHs) treating and explore their antitumor mechanism. Methods Firstly, clinical traditional medicine (TCM) prescriptions were collected from National Knowledge Infrastructure (CNKI) database, then, data mining software was used CCHs. After that,...
Colorectal cancer (CRC) is now the second most deadly globally. Chinese herbal medicine (CHM) plays an indispensable role in CRC treatment China. However, core herbs (the CHs) of and their underlying therapeutic mechanisms remain unclear. This study aims to uncovering CHs action treatment, applying data mining network pharmacology approach. First, CHM prescriptions treating were collected from clinical studies National Knowledge Infrastructure (CNKI) MEDLINE databases, identified through...
Objective. Traditional Chinese medicine (TCM) is an important part of the comprehensive treatment hepatocellular carcinoma (HCC), and materia medica formulas with effect “Yiqi Jianpi” (replenishing qi strengthening spleen) or “Jiedu” (removing toxicity) have been proved to be effective in treating HCC. However, mechanisms these HCC remain unclear. In this paper, our goal explore antitumor activity its molecular Yiqi Jianpi Jiedu (YQJPJD) formula against Methods. The bioactive ingredients...
Distant metastasis is the leading cause of cancer-related mortality, and achieving survival benefits through advancements in systemic therapy remains challenging. Mast cells play a dual role shaping tumor microenvironment (TME) influencing distant metastasis, underscoring significant research value targeting mast for advanced cancer. We investigated variations cell infiltration levels primary metastatic malignancies using immunocyte analysis. subsets were identified from pan-cancer...
The objective of this study was to explore the causal relationship between use proton pump inhibitors (PPIs) and 16 types digestive system tumors. We utilized a 2-sample Mendelian randomization (MR) approach investigate relationship. obtained exposure outcome data from UK Biobank Finland Biobank, respectively. genetic used in analysis were derived genome-wide association studies (GWAS) conducted on European populations. screened single nucleotide polymorphisms significantly associated with...
The prognosis of patients with advanced hepatocellular carcinoma (HCC) remains poor. Lipid remodeling modulators are considered promising therapeutic targets cancers, owing to their functions facilitating cancer cells' adaption the limited environment. Lysophosphatidylcholine acyltransferases (LPCATs) enzymes regulating bio-membrane remodeling, whose roles in HCC have not been fully illuminated.Multiple bioinformatic tools were applied comprehensively evaluate expression, genetic...