A5072773831- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Liver Disease and Transplantation
- Cancer Research and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Lipid metabolism and disorders
- Cancer-related Molecular Pathways
- Phytochemistry and Bioactivity Studies
- Liver Diseases and Immunity
- Healthcare and Venom Research
- Medical Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- vaccines and immunoinformatics approaches
- Inflammatory mediators and NSAID effects
- Ubiquitin and proteasome pathways
- Neurological Disease Mechanisms and Treatments
- Bacterial Infections and Vaccines
- Medicinal Plants and Bioactive Compounds
- Radiation Therapy and Dosimetry
- Rheumatoid Arthritis Research and Therapies
- Hepatocellular Carcinoma Treatment and Prognosis
Shenzhen Pingle Orthopedic Hospital
2008-2024
Nanjing University
2014-2024
Nanjing General Hospital of Nanjing Military Command
2024
Shenzhen Bao'an District People's Hospital
2020
Guangzhou University of Chinese Medicine
2011-2019
XinHua Hospital
2015
Nanjing Medical University
2013-2014
Changzhou No.2 People's Hospital
2013
Guangzhou University
2006-2009
CM Hospital
2003
Nucleotide analogs treatment can reverse liver fibrosis in chronic hepatitis B (CHB). However, it has limited effect on resolution patients with CHB, particularly preventing progression to hepatocellular carcinoma (HCC). Ruangan granule (RG), a Chinese herbal formula, proven produce therapeutic against animal experiment. Thus, we aimed evaluate the of our formula (RG) combined entecavir (ETV) advanced fibrosis/early cirrhosis from CHB. A total 240 CHB histologically confirmed 12 centers were...
// Weichao Zhong 1, 2, * , Lei Gao Zhenting Zhou 1 Haiyan Lin Chun Chen 3 Peng Huang Weiliang Chuying Shaohui Linghui Nie Ye Liu 4 Youming Daqiao 2 and Zhiping Lv School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China Department Liver Diseases, Shenzhen Medicine Hospital, Shenzhen, 518033, Pharmacology, Shantou University College, Shantou, 515041, The Third Affiliated Hospital 510630, These authors contributed equally to this work...
Background The aim of this study is to reveal the clinical and histopathological features HBsAg-positive HBeAg-positive chronic hepatitis B infected patients with high level HBV DNA, from 17 hospitals medical centres in China, alanine aminotransferase levels within lower region normal range versus those upper investigate risk factors for requirement treatment through examination liver biopsy. Methods Liver biopsy was performed on DNA 455 infection persistently level. necroinflammation...
A library of Tn916-generated, tetracycline-resistant (Tc) mutants the group B Neisseri meningitidis strain NMB was screened by using monoclonal antibodies (MAbs) that recognize structural differences in neisserial lipooligosaccharide (LOS). The LOS parental had a relative molecular mass 4.5 kDa, reacted with MAbs 3F11 and 6B4 but not MAb 4C4 or 6E4, contained lacto-N-neotetrose unit. Two phenotypically stable mutants, SS3 R6, altered LOS, were identified colony immunoblots, electrophoresis,...
Compound Phyllanthus urinaria L (CP) is a traditional formula widely used in clinical practice for hepatocellular carcinoma (HCC), especially HBV-related HCC. HBx, HBV X gene encoded protein, has positive correlation with the abnormal SHH pathway So, we predicted that CP capability of anti-HBV-related HCC maybe via inactivating HBx-Hedgehog axis. HepG2-HBx cells, HBx overexpression, were treated (70 μ g/ml and 35 g/ml, respectively) 48 hours mice which received cells (625mg/kg 300 mg/kg, 17...
Background and Aims: Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are at risk of disease progression. Currently, liver biopsy is suggested to identify this population. We aimed establish a non-invasive diagnostic model significant inflammation. Method: A total 504 CHB who had undergone ALT were randomized into training set ( n = 310) validation 194). Independent variables analyzed by stepwise logistic regression analysis. After the predictive for...
Apart from individual genetic background, unhealthy lifestyle and diet, etc., nutrition also plays an important role in the occurrence progression of gastrointestinal tumors. Although some patients with tumors can be satisfied traditional nutritional support, it is apparently inadequate for systemic management all patients. Precision known as personalized refers to safe efficient individualized intervention based on investigation life characteristics, metabolic indicators, intestinal...
No guideline recommends antiviral therapy for hepatitis B e antigen (HBeAg)-positive chronic patients with persistently normal alanine aminotransferase levels and a high virus (HBV) DNA viral load.To evaluate the feasibility safety of Chinese herbal formula as therapeutic option HBV infection.In total, 395 (30-65 years old) confirmed HBeAg-positive infection were randomized to receive either or placebo 96 wk. Endpoints efficacy included: (1) decreased less than 4 log10 IU/mL at weeks 48 96;...
A Chinese Herbal Formula (CHF) has acquired a certain therapeutic effect on chronic HBV infection. To assess the efficacy and safety of CHF replication in carriers, we performed randomized, double-blind, placebo-controlled trial involving patients from 16 centers. total 300 confirmed carriers were randomized at baseline ratio 2 : 1 to receive either or placebo for 52 weeks. The results showed that greater proportion than treated achieved virological response week 52; mean decline serum HBsAg...
This study aimed to investigate the effects of Shugan Xiaozhi decoction (SX) on nonalcoholic steatohepatitis (NASH) induced by high-fat diet in rats. The rats were randomly divided into 6 groups, namely, control, model, fenofibrate, and three different dosage SX (10, 20, 40 g/kg/day, p.o.). After establishing NASH at 8 weeks experiment, treatments administrated intragastrically fenofibrate groups. All killed after 4 treatment. Compared with model group, alanine aminotransferase (ALT),...
Abstract Number connection test A (NCT-A) and digit symbol (DST), the preferential neuropsychological tests to detect minimal hepatic encephalopathy (MHE) in China, haven’t been standardized Chinese population. We aimed establish norms based on a multi-center cross-sectional study MHE cirrhotic patients. NCT-A DST were administered 648 healthy controls 1665 The regression-based procedure was applied develop demographically adjusted for controls. Age, gender, education, age by education...
Bushen Jianpi formula (BSJPF, also known as Lingmao formula) is a traditional Chinese medicine for chronic hepatitis B (CHB). The previous study has suggested that the treatment combination of BSJPF and entecavir (ETV) can achieve significant loss e antigen (HBeAg) decrease in serum level virus (HBV) DNA HBeAg-positive CHB patients with mildly elevated alanine aminotransferase.This aimed to evaluate efficacy safety combined ETV treating HBeAg-negative patients.A total 640 were assigned...