A5100438887- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Influenza Virus Research Studies
- Malaria Research and Control
- Neurological disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Metabolomics and Mass Spectrometry Studies
- Respiratory viral infections research
- Fungal Biology and Applications
- Andrographolide Research and Applications
- Virology and Viral Diseases
- Microbial Metabolic Engineering and Bioproduction
- Immunotherapy and Immune Responses
- Tea Polyphenols and Effects
- HIV/AIDS drug development and treatment
- Glycosylation and Glycoproteins Research
- Ophthalmology and Visual Impairment Studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Bacillus and Francisella bacterial research
Shanghai Municipal Center For Disease Control Prevention
2025
Hangzhou Normal University
2025
Sinai Hospital
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2024
Chongqing Medical University
2018-2024
Chinese Academy of Sciences
2015-2024
Shanghai First People's Hospital
2024
Shanghai Eye Disease Prevention & Treatment Center
2024
Hangzhou Medical College
2020-2024
University of Chinese Academy of Sciences
2024
A window of opportunity for immune responses to extinguish human immunodeficiency virus type 1 (HIV-1) exists from the moment transmission through establishment latent pool HIV-1-infected cells. critical time study initial transmitted/founder is eclipse phase HIV-1 infection (time first appearance plasma virus), but, date, this period has been logistically difficult analyze. To probe B-cell immediately following transmission, we have determined envelope-specific antibody autologous and...
A multifunctional Nd-Ca-Si biomaterial is designed for fluorescence thermometry, photothermal therapy, and burn tissue repair.
ABSTRACT During primary infection, the number of HIV-1 particles in plasma increases rapidly, reaches a peak, and then declines until it set point level. Understanding kinetics its effect on establishment chronic is important defining early pathogenesis HIV. We studied viral dynamics very infection 47 subjects identified through donation screening. calculated how fast load variable this parameter among individuals. also estimated basic reproductive ratio, new infected cells generated by an...
A central goal of vaccine research is to identify a vaccine-induced immune response that predicts protection from infection or disease. The term "correlate protection" has been used refer at least 3 distinct concepts, which resulted in confusion surrounding this topic. We propose precise definitions these different concepts correlates, using the nomenclature risk," "level 1 surrogate protection," and 2 protection." suggest general framework for assessing levels correlates efficacy trials. To...
Background. Recombinant DNA and modified vaccinia virus Ankara (rMVA) vaccines represent a promising approach to an HIV/AIDS vaccine. This Phase 1 clinical trial compared the safety immunogenicity of rMVA vaccine administered with without priming Methods. GeoVax pGA2/JS7 (D) MVA/HIV62 (M) encode noninfectious virus-like particles. Intramuscular needle injections were used deliver placebo, 2 doses followed by (DDMM), one dose (DMM), or 3 (MMM) HIV-seronegative participants. Results. Local...
Tumor-associated macrophages (TAMs) are the most abundant immune cells within tumor stroma and play a crucial role in development. Although clinical investigations indicate that high levels of macrophage (MΦ) infiltration into tumors associated with poor prognosis, exact played by TAMs during development remains unclear. The present study aimed to investigate dynamic changes TAM major histocompatibility complex (MHC) class II expression assess effects these on progression.Significant...
Extracellular vesicles (EVs) are complex ecosystems that can be derived from all body cells and circulated in the fluids. Characterizing tissue-cellular source contributing to circulating EVs provides biological information about cell or tissue of origin their functional states. However, relative proportion fluid has not been thoroughly characterized. Here, we developed an approach for digital quantification, called EV-origin, enables enumerating contribution plasma extracellular long RNA...
Background Lung cancer is the most common malignancy in humans and its high fatality means that no effective treatment available. Developing new therapeutic strategies for lung urgently needed. Malaria has been reported to stimulate host immune responses, which are believed be efficacious combating some clinical cancers. This study aimed provide evidence malaria parasite infection cancer. Methodology/Principal Findings Antitumor effect of was examined both subcutaneously intravenously...
Significance It has been proposed, based on theory of complex gene regulatory networks, that cell types, including cancer cells, represent attractor states the network dynamics. Here, we characterize for first time, to our knowledge, detailed dynamics a at single-cell resolution. The results provide quantitative knowledge nongenetic intercellular heterogeneity and its within an isogenic population cancerous affording insights previously unidentified level resolution between molecular...
Significance Influenza A virus (IAV) is one of the most important human pathogens, and it crucial to understand its life cycle develop antiviral strategies. However, IAV uncoating, an essential step in viral infection, has remained incomprehensible. Here, via construction infectious virions encapsulating quantum dots, we tracked uncoating ribonucleoprotein complex (vRNP) dynamics single virions. Our results reveal that after fusion vRNP segments are released separately into cytosol,...
Tea is known to be one of the most popular beverages enjoyed by two-thirds world’s population. Concern variability in tea quality increasing among consumers. It great significance control for commercialized products. As a rapid, noninvasive, and nondestructive instrumental technique with simplicity sample preparation, near-infrared reflectance (NIR) spectroscopy has been proved advanced efficient tools products recent years. In this article, we review advances applications NIR chemometrics...
Chronic hepatitis B (CHB) and liver fibrosis are associated with a high risk of hepatocellular carcinoma (HCC) development. We assessed whether entecavir (ETV) plus Biejia-Ruangan compound (BRC), an anti-fibrotic traditional Chinese medicine, can further reduce the HCC in treatment-naïve patients CHB Ishak score ≥3 points derived from our parent double-blind randomized placebo-controlled trial.After 72-week comparison between ETV+BRC ETV+placebo treatment, participants were eligible to enter...
Rucheng Baimao (Camellia pubescens) is an excellent raw material for manufacturing white tea. Drying the last step in tea processing and essential tea's aroma. In this study, aroma sensory evaluation combined with volatile compound analysis reveals characteristic differences of oven drying (OD), air (AD), sun (SD) treatments. Sensory results showed that OD samples had a stronger floral grassy aroma, AD exhibited more pronounced fresh pekoe SD unique sunshine odor. Thirty compounds were...
To compare the efficacy and safety of low-level red light (LRL) in controlling myopia progression at 3 different powers: 0.37 mW, 0.60 1.20 mW.Single-center, single-masked, randomized controlled trial.Two hundred children aged 6-15 with -0.50 diopter (D) or more astigmatism -2.50 D less were enrolled from April to May 2022. Follow-up ended December 2022.Participants assigned randomly intervention groups 1 control group (1:1:1:1). All participants wore single-vision spectacles. Moreover,...
The escalating global consumption of tetracyclines (TCs) as broad-spectrum antibiotics necessitates innovative approaches to mitigate their pervasive environmental persistence and associated risks. While initiatives such China's antimicrobial reduction efforts highlight the urgency responsible TC usage, need for efficient degradation methods remains paramount. Microbial emerges a promising solution, offering novel insights into pathways mechanisms. Despite challenges, including optimization...
Ergothioneine is a histidine thiol derivative. Its mycobacterial biosynthetic pathway has five steps (EgtA-E catalysis) with two novel reactions: mononuclear nonheme iron enzyme (EgtB) catalyzed oxidative C–S bond formation and PLP-mediated lyase (EgtE) reaction. Our bioinformatic biochemical analyses indicate that the fungus Neurospora crassa more concise ergothioneine because its enzyme, Egt1, makes use of cysteine instead γ-Glu-Cys as substrate. Such change substrate preference eliminates...
Macrophages are one of the major targets human immunodeficiency virus (HIV-1), but viral entry pathway remains poorly understood in these cells. Noninvasive labeling and single-virus tracking effective tools for studying entry. Here, we constructed a quantum dot (QD)-encapsulated infectious HIV-1 particle to track at single-particle level live primary macrophages. QDs were encapsulated virions by incorporating accessory protein Vpr-conjugated during assembly. With particles encapsulating...
IMPORTANCE Digital health applications have been shown to be effective in the management of chronic diseases with simple treatment targets. The potential clinical value digital rheumatoid arthritis (RA) has not well studied. OBJECTIVE To investigate whether assessing patient-reported outcomes using could result disease control for patients RA. DESIGN, SETTING, AND PARTICIPANTS This is a multicenter, open-label randomized trial 22 tertiary hospitals across China. Eligible participants were...
The death of CD4(+) CCR5(+) T cells is a hallmark human immunodeficiency virus (HIV) infection. We studied the plasma levels cell mediators and products--tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), Fas ligand, TNF receptor type 2 (TNFR-2), microparticles--during earliest stages infection following HIV 1 (HIV-1) transmission in samples from U.S. donors. Significant TRAIL level elevations occurred mean 7.2 days before peak viral load (VL), while TNFR-2, microparticle...
ABSTRACT The major hydrophilic region (MHR) of hepatitis B surface antigen (HBsAg) harbors conformational B-cell epitopes and is the target neutralizing antibodies to HBsAg (anti-HBs). Mutant (mtHBsAg) with amino acid substitutions such as G145R known affect binding specific anti-HB their detection by conventional diagnostic assays. In present study, we focused on role positions 120 123, which are around MHR 2 according spectrum recently identified, naturally occurring mtHBsAg. Strikingly,...
The liver plays a central role in cholesterol homeostasis. It exclusively receives and metabolizes oxysterols, which are important metabolites of more cytotoxic than free cholesterol, from all extrahepatic tissues. Hepatocellular carcinomas (HCCs) impair certain functions cause pathological alterations many processes including metabolism. However, the link between an altered metabolism HCC development is unclear. Human ACAT2 abundantly expressed intestine fetal liver. Our previous studies...