A5100390232- interferon and immune responses
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- COVID-19 diagnosis using AI
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- Reproductive Biology and Fertility
- Lung Cancer Diagnosis and Treatment
- Medical Research and Treatments
- Immune Cell Function and Interaction
- Sodium Intake and Health
- Nutritional Studies and Diet
- Sperm and Testicular Function
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects and Toxicity Studies
- Studies on Chitinases and Chitosanases
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Stroke Rehabilitation and Recovery
- Tuberculosis Research and Epidemiology
- Attention Deficit Hyperactivity Disorder
Panzhihua Central Hospital
2024-2025
The University of Texas Southwestern Medical Center
2024-2025
First Affiliated Hospital of Henan University
2024
Harbin Medical University
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Nanjing Medical University
2022-2024
Shenzhen Research Institute of Big Data
2023-2024
Capital Medical University
2024
Pathogen infection and tissue injury are universal insults that disrupt homeostasis. Innate immunity senses microbial infections induces cytokines/chemokines to activate resistance mechanisms. Here, we show that, in contrast most pathogen-induced cytokines, interleukin-24 (IL-24) is predominately induced by barrier epithelial progenitors after independent of microbiome or adaptive immunity. Moreover, Il24 ablation mice impedes not only epidermal proliferation re-epithelialization but also...
Stem cells remember Tissue stem sense their surroundings, and this perception influences subsequent fate function. Gonzales et al . observed that accumulate epigenetic memories of diverse environmental events (see the Perspective by Hoste). By wounding skin monitoring temporal steps involved in mobilizing hair follicle to repair epidermis, authors found bear original niche, migration, encounters with inflammation, adaptation new tasks. During homeostasis, immigrant are functionally...
To compare the efficacy and safety of low-level red light (LRL) in controlling myopia progression at 3 different powers: 0.37 mW, 0.60 1.20 mW.Single-center, single-masked, randomized controlled trial.Two hundred children aged 6-15 with -0.50 diopter (D) or more astigmatism -2.50 D less were enrolled from April to May 2022. Follow-up ended December 2022.Participants assigned randomly intervention groups 1 control group (1:1:1:1). All participants wore single-vision spectacles. Moreover,...
The stimulator of interferon genes (STING) plays a pivotal role in orchestrating innate immunity, and dysregulated activity STING has been implicated the pathogenesis autoimmune diseases. Recent findings suggest that bacterial infection activates STING, relieving ER stress, triggers non-canonical autophagy by spatially regulating STX17. Despite these insights, precise mechanism governing dynamics autophagosome fusion elicited remains unclear. In this study, we demonstrate dynamic activation...
Abstract Aims Excessive influx of manganese (Mn) into the brain across blood–brain barrier induces neurodegeneration. CYP1B1 is involved in metabolism arachidonic acid (AA) that affects vascular homeostasis. We aimed to investigate effect on Mn‐induced neurotoxicity. Method Brain Mn concentrations and α‐synuclein accumulation were measured wild‐type knockout mice treated with MnCl 2 (30 mg/kg) biotin (0.2 g/kg) for 21 continuous days. Tight junctions oxidative stress analyzed hCMEC/D3...
Abstract The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). ChP–CSF system not only provides necessary cushion for brain but also works as a sink waste clearance. During sepsis, pathogens and host immune cells can weaken ChP barrier enter brain, causing cerebral dysfunctions known sepsis‐associated encephalophagy. Here, we used human organoid (ChPO) to model herpes simplex virus type 1 (HSV‐1) infection found epithelial were highly susceptible HSV‐1. Since current ChPO...
The anthocyanins from Aronia melanocarpa (AAM) have captured the interest of researchers because their potential health-related functionalities. However, application is limited by poor stability. Therefore, to improve physical and oxidative stability, single factor orthogonal tests were designed optimize preparation conditions chitosan/β-Lactoglobulin encapsulating AAM (M-AAM) evaluated nanocapsules in terms physicochemical characteristics, storage oxidant stability during vitro simulated...
Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic...
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, particularly among older adults. Identifying modifiable dietary factors associated with CVD prevalence is essential for prevention. This cross-sectional study analyzed 7,341 adults aged ≥ 65 years from NHANES 2007-2018. was defined based on self-reported physician-diagnosed conditions, including coronary heart disease, failure, angina, attack, or stroke. A nutrient-wide association (NWAS) evaluated associations...
The aim of this study was to leverage volumetric quantification airspace disease (AD) derived from a superior modality (computed tomography [CT]) serving as ground truth, projected onto digitally reconstructed radiographs (DRRs) (1) train convolutional neural network (CNN) quantify AD on paired chest (CXRs) and CTs, (2) compare the DRR-trained CNN expert human readers in CXR evaluation patients with confirmed COVID-19.We retrospectively selected cohort 86 COVID-19 (with positive reverse...
Background Executive dysfunction in children with attention deficit hyperactivity disorder (ADHD) is thought to be closely related the prefrontal cortex (PFC). However, there controversy over activation of PFC ADHD. Differences could subtype. Meanwhile, no study date has used functional near-infrared spectroscopy (fNIRS) explore differences between subtypes. Thus, this aimed different subtypes ADHD during executive function task. Methods Participants include typically developing (TD) ( n =...
Finger technique is crucial in piano learning; hand exoskeleton mechanisms assist novice players maintaining correct technique. A novel robot for assistance addresses current issues like limited correction ability and weight. joint angle sensors gather data on finger movements, enabling quantitative analysis of playing characteristics. This guides design to maintain vertical strikes the distal segment. 6-bar double-closed-loop mechanism with an end equivalent sliding pair chosen. Analytical...
Autophagy is a highly conserved catabolic pathway that vital for cells; however, the effects of autophagy on biofilm formation and antifungal resistance Candida albicans are still unknown. In this study, potential molecular mechanisms in were investigated. It was found 3536 genes differentially expressed between planktonic C. albicans. ATG gene expression activity higher than Autophagic activities matured biofilms pre-matured biofilms. involved its increased during maturation. Further, ALP...
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disrupts the blood-testis barrier (BTB), resulting in alterations spermatogenesis. However, whether BTB-related proteins (such as ZO-1, claudin11, N-cadherin, and CX43) are targeted by SARS-CoV-2 remains to be clarified. BTB is a physical between blood vessels seminiferous tubules of animal testis, it one tightest blood-tissue barriers mammalian body. In this study, we investigated effects viral proteins, via ectopic expression...
Context.— Fondaparinux monitoring is not required among noncritically ill patients due to a predictable dose-response effect. However, this debatable critically patients, because fondaparinux bioavailability can be influenced by complicated medical conditions. Objective.— To investigate the ill. Design.— Retrospective analysis of admitted in intensive care unit from February 2021 December who received prophylactic and had anti-Xa activity tests. Results.— Of 156 values, 86 (55.1%) were...
Finger technique is a crucial aspect of piano learning, and hand exoskeleton mechanisms effectively assist novice players in maintaining correct finger consistently. Addressing current issues with robots, such as the inability to provide continuous correction their considerable weight, novel robot has been developed enhance through reduced weight. Initial data are gathered using joint angle sensors analyze movements during playing, focusing on trajectory angular velocity key strikes. This...