A5103217077- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Endometriosis Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Dental Education, Practice, Research
- Wound Healing and Treatments
- Biomedical Ethics and Regulation
- Immune responses and vaccinations
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Biofuel production and bioconversion
- Mesenchymal stem cell research
- Plant Molecular Biology Research
- Gynecological conditions and treatments
- Immune Response and Inflammation
- HIV Research and Treatment
- Extracellular vesicles in disease
- Cellular Mechanics and Interactions
- Medical and Biological Sciences
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
Plovdiv University
2024
National Center of Infectious and Parasitic Diseases
2024
Howard Hughes Medical Institute
2015-2022
Rockefeller University
2015-2022
Stem cells remember Tissue stem sense their surroundings, and this perception influences subsequent fate function. Gonzales et al . observed that accumulate epigenetic memories of diverse environmental events (see the Perspective by Hoste). By wounding skin monitoring temporal steps involved in mobilizing hair follicle to repair epidermis, authors found bear original niche, migration, encounters with inflammation, adaptation new tasks. During homeostasis, immigrant are functionally...
Abstract STUDY QUESTION What changes occur in the endometrium during aging, and do they impact fertility? SUMMARY ANSWER Both transcriptome cellular composition of endometrial samples from women advanced maternal age (AMA) are significantly different that young women, suggesting specific epithelial cells may affect receptivity. WHAT IS KNOWN ALREADY Aging is associated with accumulation senescent aging tissues. Reproductive mostly attributed to decline ovarian reserve oocyte quality, whereas...
The endometrium, the inner mucosal lining of uterus, undergoes complex molecular and cellular changes across menstrual cycle in preparation for embryo implantation. Transcriptome-wide analyses have mainly been utilized to study endometrial receptivity, prerequisite successful implantation, with most studies, so far, comparing transcriptomes between (i) secretory proliferative endometrium or (ii) mid-secretory early endometrium. In current study, we provide a complete transcriptome...
Embryo implantation depends on endometrial receptivity (ER). To achieve ER, the preparation of uterine lining requires controlled priming by ovarian hormones and expression numerous genes in tissue. microRNAs (miRs) have emerged as critical genetic regulators ER fertility diseases that are associated with infertility. With rapid development next-generation sequencing technologies, it has become clear miR can produce canonical miRs variants-isomiRs. Here, we describe miR/isomiR dynamics...
The endometrium, the inner mucosal lining of uterus, undergoes complex molecular and cellular changes across menstrual cycle in preparation for embryo implantation. Transcrip-tome-wide analyses have mainly been utilized to study endometrial receptivity, prerequisite successful implantation, with most studies, so far, comparing transcriptomes between (i) secretory versus proliferative endometrium or (ii) mid-secretory early-secretory endometrium. In current study, we provide complete...
The connection between the mother and child has been considered one of strongest bonds in nature. Though there are numerous factors that can influence establishment pregnancy, its essence three major: a good quality embryo, receptive endometrium successful cross-talk them. placenta, derives from trophoblast develops when implantation occurs. It is an ephemeral organ through which turnover nutrient, gas waste molecules realized. serves as barrier provide embryo with immune factors. Placental...
Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation better cope. The ISR has also been implicated in cancers, but redundancies stress-sensing kinases that trigger have posed hurdles dissecting physiological relevance. To overcome this challenge, we targeted regulatory node of these kinases, namely, S51 phosphorylation site eukaryotic initiation factor eIF2α genetically replaced with eIF2α-S51A mouse...
The human endometrium is a highly dynamic tissue. Increasing evidence has shown that microRNAs (miRs) play essential roles in development. Our previous assay, based on small RNA-sequencing (sRNA-seq) indicated the complexity and dynamics of numerous sequence variants miRs (isomiRs) can act together to control genes functional relevance receptive (RE). Here, we used greater average depth sRNA-seq detect poorly expressed RNAs. sequencing data confirmed up-regulation miR-449c uncovered other...
Introduction: Elevation of intracellular iron concentration triggers ferroptosis. Understanding the regulation and pathophysiological mechanisms this process in HIV infection may contribute to antiretroviral therapy (cART) monitoring. Aim: To perform a correlation analysis labile-bound pool (LIP) CD4+ CD8+ T cells association with CD4+, absolute count (AC) CD4/CD8 index HIV+ individuals on continuous cART sustained viral suppression. Material methods: Peripheral blood samples (Li heparin,...
Abstract MiRNAs are evolutionarily conserved small non-coding RNAs that orchestrate a wide spectrum of physiological and pathological processes in stem cells (SCs) human cancers. Intimately wired into oncogenic tumor suppressive networks, miRs valuable as not only diagnostic biomarkers but also therapeutic targets. Squamous cell carcinomas (SCCs) among the most life-threatening cancers world-wide. Using skin paradigm, we describe first panoramic view during development, homeostasis malignant...
Abstract MiRNAs are evolutionarily conserved small non-coding RNAs that orchestrate a wide spectrum of physiological and pathological processes in stem cells (SCs) human cancers. Intimately wired into oncogenic tumor suppressive networks, miRs valuable as not only diagnostic biomarkers but also therapeutic targets. Squamous cell carcinomas (SCCs) among the most life-threatening cancers world-wide. Using skin paradigm, we describe first panoramic view during development, homeostasis malignant...
Abstract When cells encounter stressful situations, they activate the integrated stress response (ISR), which limits total protein synthesis and redirects translation to proteins that help cope. The ISR has also been implicated in cancers, but redundancies stress-sensing kinases trigger have posed hurdles dissecting physiological relevance. To overcome this challenge, we targeted regulatory node of these kinases, namely S51 phosphorylation site eukaryotic initiation factor eIF2α genetically...