A5110542423- Genomics and Chromatin Dynamics
- Hair Growth and Disorders
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Lipid metabolism and biosynthesis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Plant Molecular Biology Research
- Wound Healing and Treatments
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Proteoglycans and glycosaminoglycans research
- IoT and Edge/Fog Computing
- Cancer Genomics and Diagnostics
- Biomedical Ethics and Regulation
- Single-cell and spatial transcriptomics
- Protein Degradation and Inhibitors
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and disorders
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
Western Sydney University
2024-2025
Howard Hughes Medical Institute
2015-2023
Rockefeller University
2015-2023
Regeneron (United States)
2020-2023
University of Graz
2014
Royal London Hospital
1939
Willesden Community Rehabilitation Hospital
1939
Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway represents a promising therapeutic approach for individuals with homozygous familial hypercholesterolemia due to LDLR mutations. Yet, how levels is unknown. Here, we demonstrate in hyperlipidemic humans mice that controls VLDL catabolism upstream LDL. Using kinetic, lipidomic, biophysical studies,...
Abstract During development, progenitors simultaneously activate one lineage while silencing another, a feature highly regulated in adult stem cells but derailed cancers. Equipped to bind cognate motifs closed chromatin, pioneer factors operate at these crossroads, how they perform fate switching remains elusive. Here we tackle this question with SOX9, master regulator that diverts embryonic epidermal (EpdSCs) into becoming hair follicle cells. By engineering mice re-activate SOX9 EpdSCs,...
Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences reflect tumor microenvironment. By vivo super-enhancer transcriptional profiling, uncover a dynamic cancer-specific epigenetic network selectively enriched for binding motifs factor cohort expressed squamous cell carcinoma SCs...
Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E ( INHBE , activin E) loss-of-function variants are associated with lower waist-to-hip ratio protection from type 2 diabetes. Hepatic fatty acid sensing promotes expression during fasting in obese individuals, yet it unclear how the hepatokine governs body shape energy metabolism. Here, we uncover as regulator of adipose storage. By suppressing β-agonist-induced lipolysis,...
Fibroblast growth factor 21 (FGF21) is a PPARα-regulated gene elucidated in the liver of PPARα-deficient mice or PPARα agonist-treated mice. Mice globally lacking adipose triglyceride lipase (ATGL) exhibit marked defect TG catabolism associated with impaired PPARα-activated expression heart and liver, including drastic reduction hepatic FGF21 mRNA expression. Here we show that markedly increased ATGL-deficient accompanied by elevated endoplasmic reticulum (ER) stress markers, which can be...
The growing complexity and volume of genomic omics data present critical challenges for storage, transfer, analysis in edge–cloud platforms. Existing compression techniques often involve trade-offs between efficiency speed, requiring innovative approaches that ensure scalability cost-effectiveness. This paper introduces a lossless method integrates Trie-based shared dictionaries within an architecture. It presents software-centric scientific research process the design evaluation proposed...
Abstract V-set and immunoglobulin domain-containing 4 (VSIG4) is a complement receptor of the superfamily that specifically expressed on tissue resident macrophages, its many reported functions binding partners suggest complex role in immune function. VSIG4 to have surveillance as well modulating diverse disease phenotypes such infections, autoimmune conditions, cancer. However, mechanism(s) governing VSIG4’s complex, context-dependent regulation remains elusive. Here, we identify cell...
Introduction The healthcare landscape is rapidly evolving through the integration of diverse data sources such as electronic health records, omics, and genomic into patient profiles, enhancing personalized medicine system interoperability. However, this transformation faces challenges in analysis, compounded by technologic advancements increasing volume data. Methods This study introduces a novel hybrid edge-cloud framework designed to manage surge multidimensional omics sector. It combines...