Olivier Elemento
A5061702711- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Computational Drug Discovery Methods
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Immune Cell Function and Interaction
Lander Institute
2016-2025
Weill Cornell Medicine
2016-2025
Cornell University
2016-2025
New York Hospital Queens
2016-2025
NewYork–Presbyterian Hospital
2016-2025
Presbyterian Hospital
2016-2025
MIND Research Institute
2021-2024
Institute of Molecular Biology and Biophysics
2020-2023
Institute for Biomedicine
2015-2023
Hospital for Special Surgery
2023
Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. Although the prevalence germline among men localized cancer who unselected for family predisposition is insufficient to warrant routine testing, frequency patients metastatic has not been established.
Cancer chromatin accessibility landscape The Genome Atlas (TCGA) provides a high-quality resource of molecular data on large variety human cancers. Corces et al. used recently modified assay to profile determine the accessible in 410 TCGA samples from 23 cancer types (see Perspective by Taipale). When were integrated with other omics available for same tumor samples, inherited risk loci predisposition revealed, transcription factors and enhancers driving subtypes patient survival differences...
Abstract Precision medicine is an approach that takes into account the influence of individuals' genes, environment, and lifestyle exposures to tailor interventions. Here, we describe development a robust precision cancer care platform integrates whole-exome sequencing with living biobank enables high-throughput drug screens on patient-derived tumor organoids. To date, 56 tumor-derived organoid cultures 19 xenograft (PDX) models have been established from 769 patients enrolled in...
Getting all stressed out by vitamin C Few experimental cancer therapies have incited as much debate C. Yet the mechanistic effect of on cells is still poorly understood. Yun et al. studied human colorectal with KRAS or BRAF mutations and found that they “handle” in a different way than other cells, ultimately to their detriment (see Perspective Reczek Chandel). Because certain receptor up-regulated mutant take up oxidized form (dehydroascorbate). This leads oxidative stress, inactivation...
The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some cancers escape dependence and are often associated with aggressive phenotype. oestrogen alpha (ERα) is expressed cancers, independent of AR status. However, the ERα remains elusive. Using combination chromatin immunoprecipitation (ChIP) RNA-sequencing data, we identified ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic...
Abstract Protein phosphorylation is one of the most widespread post-translational modifications in biology 1,2 . With advances mass-spectrometry-based phosphoproteomics, 90,000 sites serine and threonine have so far been identified, several thousand associated with human diseases biological processes 3,4 For vast majority events, it not yet known which more than 300 protein serine/threonine (Ser/Thr) kinases encoded genome are responsible 3 Here we used synthetic peptide libraries to profile...
Visual morphology assessment is routinely used for evaluating of embryo quality and selecting human blastocysts transfer after in vitro fertilization (IVF). However, the produces different results between embryologists as a result, success rate IVF remains low. To overcome uncertainties quality, multiple embryos are often implanted resulting undesired pregnancies complications. Unlike other imaging fields, embryology have not yet leveraged artificial intelligence (AI) unbiased, automated...