A5080848884- RNA modifications and cancer
- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Cancer-related gene regulation
- RNA and protein synthesis mechanisms
- Plant Pathogenic Bacteria Studies
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Chromosomal and Genetic Variations
- Phytoplasmas and Hemiptera pathogens
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- HVDC Systems and Fault Protection
- Lipid metabolism and disorders
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Plant biochemistry and biosynthesis
- Plant Molecular Biology Research
- Insect symbiosis and bacterial influences
Gannan Normal University
2021-2025
China Pharmaceutical University
2011-2025
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Shandong Freshwater Fisheries Research Institute
2019-2024
Affiliated Hospital of Southwest Medical University
2024
Shandong Normal University
2021-2024
Urumqi 4th People's Hospital
2024
Xiamen University
2024
Suzhou Polytechnic Institute of Agriculture
2008-2023
During apoptotic cell death, surface ligands initiate phagocytosis of the dying cell. Clearance these cells is thought to occur without an immune response. Since a number autoantigens are located at or within blebs, we examined whether exposure mice syngeneic by intravenous route could induce autoantibody production. Normal injected with thymocytes developed antinuclear autoantibodies and anticardiolipin anti-ssDNA antibodies. The levels were generally lower than those observed in MRL/Faslpr...
Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, heterochromatin loss has been proposed to be one the causes aging. However, role in animal controversial. Here we show that formation prolongs lifespan controls ribosomal RNA synthesis Drosophila. Animals with decreased levels exhibit dramatic shortening lifespan, whereas increasing lifespan. The changes are associated muscle integrity. Furthermore, decrease normal essential for silencing rRNA transcription....
Increased expression of type I interferon (IFN) and a broad signature IFN-induced gene transcripts are observed in patients with systemic lupus erythematosus (SLE) other autoimmune diseases. To identify disease-relevant triggers the IFN pathway, this study sought to investigate whether endogenous virus-like genomic repeat elements, normally silent, expressed disease, these retroelements could activate an innate immune response induce IFN.Expression long interspersed nuclear element 1...
Reversible post-transcriptional modifications on messenger RNA emerge as prevalent phenomena in metabolism. The most abundant among them is N
N6-methyladenosine (m6A) plays crucial roles in regulating RNA metabolisms. METTL16 identified as a single-component methyltransferase catalyzes m6A formation the nucleus; whether it regulates cytoplasmic fate remains unknown. Here, we detected dual localization of nucleus and cytoplasm. depletion attenuates protein synthesis, but activity is not required for its translation-promoting function. Mechanistically, an interactor METTL16, eIF4E2, which represses translation by acting competitor...
Interferon (IFN) signature genes have been shown to be expressed highly in peripheral blood of patients with systemic lupus erythematosus (SLE), especially the presence active disease. However, expression this gene individuals incomplete forms and pathogenic relationship between IFN autoantibody production not explored fully. In present study, we examined profiles diagnosed (ILE) determine correlations production. Gene analysis was carried out on 24K Illumina Human Refseq-8 arrays using...
Copy-number variants (CNVs) reshape gene structure, modulate expression, and contribute to significant phenotypic variation. Previous studies have revealed CNV patterns in natural populations of Drosophila melanogaster suggested that selection mutational bias shape genomic CNV. Although previous focused on heterogeneous strains, here, we established a number second-chromosome substitution lines uncover characteristics when homozygous. The percentage genes harboring CNVs is higher than found...
Continuous exposure of breast cancer cells to adriamycin induces high expression P-gp and multiple drug resistance. However, the biochemical process underlying mechanisms for gradually induced resistance are not clear. To explore mechanism evaluate anti-tumor effect adriamycin, drug-sensitive MCF-7S drug-resistant MCF-7Adr were used treated with intracellular metabolites profiled using gas chromatography mass spectrometry. Principal components analysis data revealed that two cell lines...
Amino acids typically are encoded by multiple synonymous codons that not used with the same frequency. Codon usage bias has drawn considerable attention, and several explanations have been offered, including variation in GC-content between species. Focusing on a simple parameter-combined GC proportion of all for particular amino acid, termed GCsyn-we try to deepen our understanding relationship acid/codon more details. We analyzed 65 widely distributed representative species found close...
Abstract The ATP binding cassette (ABC) transporters superfamily is one of the largest classes membrane proteins. core ABC transporter protein composed transmembrane domains (TMDs) and nucleotide (NBD). Eukaryotes are classified into seven main families (ABCA to ABCG) based on sequence similarity domain organizations. With different number organizations, eukaryote show diverse structures: single structure (NBD or TMD), ABC2 (NBD-NBD), half (TMD-NBD NBD-TMD) full (TMD-NBD-TMD-NBD...
Significance Finding the genes that control a complex trait is difficult because each gene may have only minor phenotypic effects. Quantitative loci mapping and genome-wide association study techniques been developed for this purpose but are laborious time-consuming. Here we method combining pedigree analysis, whole-genome sequencing, CRISPR-Cas9 technology. By sequencing parents descendants of IR8, Green Revolution “miracle rice,” identified many had retained in by selection high yield....
The pathogenesis of acute kidney injury (AKI) is still not fully understood, and effective interventions are lacking. Here, we explored whether methyltransferase 3 (METTL3) was involved in the progression AKI via regulation cell death. We reported that PT(proximal tubule)-METTL3-knockout (KO) noticeably suppressed ischemic-induced inhibition renal apoptosis. Furthermore, also found expression mmu-long non-coding RNA (lncRNA) 121686 upregulated antimycin-treated Boston University mouse...
Although the Drosophila Y chromosome is degenerated, heterochromatic, and contains few genes, increasing evidence suggests that it plays an important role in regulating expression of numerous autosomal X-linked genes. Here we use 15 chromosomes originating from a single founder 550 generations ago to study rRNA gene transcription, position-effect variegation (PEV), link among rDNA copy number, global expression, chromatin regulation. Based on patterns transcription indicated by...
Background HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for infection currently available. However, PIs have now been linked to lipodystrophy and dyslipidemia, which major risk factors cardiovascular disease metabolic syndrome. Our previous studies shown that activate endoplasmic reticulum (ER) stress disrupt lipid metabolism in hepatocytes macrophages. Yet, little is known on how adipocytes, a cell type...
Starch is biosynthesised by a complex of enzymes including various starch synthases and branching debranching enzymes, amongst others. The role all these has been investigated using gene silencing or genetic knockouts, but there are few examples overexpression due to the problems either cloning large genomic fragments toxicity functional cDNAs bacteria during cloning. aim this study was investigate function potato STARCH BRANCHING ENZYME II (SBEII) in tubers. A hybrid SBEII intragene...
Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of modifications its machinery, including FTO, to development several forms cancers. However, functional role hepatic metabolism progression hepatocellular carcinoma (HCC), proteotypic obesity-associated cancer, remains unclear. Thus, we aimed reveal initiation HCC vivo. We generated mice deficiency (FTOL−KO). The effect on was...