A5038555930- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- Atherosclerosis and Cardiovascular Diseases
- Drug-Induced Hepatotoxicity and Protection
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Soybean genetics and cultivation
- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Phytoestrogen effects and research
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- Celiac Disease Research and Management
- Epigenetics and DNA Methylation
The University of Texas Southwestern Medical Center
2003-2020
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that characterized by defective immune tolerance combined with cell hyperactivity resulting in the production of pathogenic autoantibodies. Previous gene expression studies employing whole blood or peripheral mononuclear cells (PBMC) have demonstrated majority patients active increased type I interferon (IFN) inducible transcripts known as IFN signature. The goal current study was to assess profiles isolated leukocyte subsets...
The finding of antinuclear antibody (ANA) positivity in a healthy individual is usually unknown significance and most cases benign. However, subset such individuals at risk for development autoimmune disease. We examined demographic immunological features that are associated with ANA clinically persons to develop insights into when this marker carries progression lupus. Biological samples from patients systemic lupus erythematosus (SLE) were obtained the Dallas Regional Autoimmune Disease...
Interferon (IFN) signature genes have been shown to be expressed highly in peripheral blood of patients with systemic lupus erythematosus (SLE), especially the presence active disease. However, expression this gene individuals incomplete forms and pathogenic relationship between IFN autoantibody production not explored fully. In present study, we examined profiles diagnosed (ILE) determine correlations production. Gene analysis was carried out on 24K Illumina Human Refseq-8 arrays using...
Drug-induced liver injury (DILI) sometimes presents with an autoimmune hepatitis-like phenotype (AI-DILI), and it is challenging to distinguish from de novo hepatitis (AIH). We conducted a study identify autoantibodies unique AI-DILI by profiling serum autoantibodies. Autoantibodies were quantified using autoantigen array containing 94 autoantigens four groups: (n = 65), DILI controls 67), AIH 17), healthy (HCs; n 30). In 37 patients AI-DILI, samples also collected 6 months after...
Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome characterized by various co-existing autoantibodies (autoAbs) in patients’ blood. However, the full spectrum of autoAbs SLE has not been comprehensively elucidated. In this study, commercial platform bearing 9400 antigens (ProtoArray) was used to identify that were significantly elevated sera patients. By comparing autoAb profiles patients with those healthy controls, we identified 437 IgG and 1213 IgM expression...
Motivation: While the mechanism for regulating alternative splicing is poorly understood, secondary structure has been shown to be integral this process. Due their propensity forming complementary hairpin loops and elevated mutation rates, tandem repeated sequences have potential influence regulation. Results: An analysis of human intronic reveals a strong correlation between prevalence mono- through hexanucleotide repeats that may engage in pairing introns flank alternatively spliced exons....
Obesity, as a metabolic disorder, can be either cause or consequence of epigenetic alterations, but their temporal relationship is unknown. This study assessed the hypothesis that BMI and DNA methylation changes mutually influence each other, dependent on different sites in human genome. Peripheral leukocyte data 294,840 CpG filtered from 485,577 generated by Illumina 450K BeadChip were analyzed two discovery cohorts (585 whites 245 blacks) longitudinal cohort (95 43 blacks followed 3.2...
Abstract Antinuclear antibodies (ANA) are serological hallmarks of SLE. Studies have shown that healthy individuals also develop ANA, raising questions on relevance ANA positivity and autoimmune disease. We screened 2223 controls (HC) 143 SLE patients for by ELISA found 26% HC positive, with 17% moderate (20-40 AU) 9% high (>40 levels. To elucidate the autoantibody profiles associated in SLE, we performed autoantigen arrays to profile over 90 autoAbs positive make significant amount...
Abstract Systemic erythematosus lupus (SLE) is an autoimmune disease characterized by presence of autoantibodies against a broad spectrum self-antigens. In order to identify novel serum associated with SLE, we utilized protoarray bearing 10,000 antigens screen IgG and IgM autoAbs in sera SLE patients. 446 1218 were significantly increased compared health controls (p<0.05), which 367 autAbs overlapped IgM. Except the previously identified patients, such as anti-DNA, Ro, La, etc., also...
It is our belief that the genomic annotations and data formats will eventually converge into more standardized forms. At such time, an effective retrieval confluence can be attained elaborate annotation heuristics may not necessary. This has begun to happen already with LocusLink project where several databases are linked provide a "one-stop-shopping" resource for genomic, genetic, phenotypic information tied together by single gene locus identifier. Overall, we were able identify number of...