A5066808172- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Cell Function and Interaction
- Health, psychology, and well-being
- Pneumocystis jirovecii pneumonia detection and treatment
- Gout, Hyperuricemia, Uric Acid
- Biochemical and Molecular Research
- Spondyloarthritis Studies and Treatments
- Peripheral Neuropathies and Disorders
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Infectious Diseases and Tuberculosis
- Eosinophilic Disorders and Syndromes
- Effects of Vibration on Health
- Bone and Joint Diseases
- Flavonoids in Medical Research
- Biomedical Ethics and Regulation
- Vasculitis and related conditions
- Ocular Surface and Contact Lens
University of Washington
2016-2025
Center for Rheumatology
2018-2020
Cooper University Hospital
2017
Cooper Medical School of Rowan University
2012-2016
Rowan University
2013-2015
National University College
2014
University Medical Center Groningen
2014
Seoul National University Hospital
2014
The University of Texas Southwestern Medical Center
2004-2013
Johnson University
2012
The Fibromyalgia Impact Questionnaire (FIQ) is a commonly used instrument in the evaluation of fibromyalgia (FM) patients. Over last 18 years, since publication original FIQ, several deficiencies have become apparent and cumbersome scoring algorithm has been barrier to widespread clinical use. aim this paper describe validate revised version FIQ: FIQR.The FIQR was developed response known FIQ with help patient focus group. same 3 domains as (that is, function, overall impact symptoms). It...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that characterized by defective immune tolerance combined with cell hyperactivity resulting in the production of pathogenic autoantibodies. Previous gene expression studies employing whole blood or peripheral mononuclear cells (PBMC) have demonstrated majority patients active increased type I interferon (IFN) inducible transcripts known as IFN signature. The goal current study was to assess profiles isolated leukocyte subsets...
Objective To validate the 2011 modification of 2010 American College Rheumatology (ACR) preliminary criteria for diagnosis fibromyalgia (2011ModCr) and develop alternative in a sample patients with diverse pain disorders that are commonly seen everyday practice by specialists, rheumatologists, psychologists. Methods Eight clinicians from geographically varied locations US evaluated chronic psychiatric using standard set questions included 2011ModCr questions, Symptom Impact Questionnaire...
Objectives To investigate whether biomarkers related to B cell activation and autoantibody production are associated with the response abatacept in rheumatoid arthritis (RA) patients. Methods Twenty-five patients RA were enrolled this study. Responders (n=10) subjects who achieved ACR50 at week 24. Serum levels of soluble measured ProcartaPlex by Luminex or ELISA. Peripheral blood mononuclear cells isolated analysed for T subsets flow cytometry. Patients genotyped human leukocyte antigen...
Reference 1. Bennett RM, Friend R, Jones KD, Ward Han BK, Ross RL: The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties. Arthritis Res Ther 2009, 11:R120. Correction Correction: properties Robert M Bennett1, Ronald Friend1,2, Kim D Jones1, Rachel Ward1, Bobby K Han3 Rebecca L Ross1
TNF inhibitors have been used as a treatment for moderate to severe RA patients. However, reliable biomarkers that predict therapeutic response are lacking. In this study, we investigated whether chemokines may represent useful the inhibitor therapy in RA.RA patients (n = 29) who were initiating adalimumab or etanercept recruited from rheumatology clinics at Cooper University Hospital. evaluated baseline and 14 weeks after therapy, serum levels of CXCL10, CXCL13, CCL20 measured by ELISA....
Objective . The study goals were to evaluate performance of SLE classification criteria, define patients with incomplete lupus erythematosus (ILE), and probe for features in these that might be useful as indicators disease status hydroxychloroquine response. Methods Patients ILE (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle="italic">70</mml:mn></mml:math>) id="M2"><mml:mi>N</mml:mi><mml:mo>=</mml:mo><mml:mn...
Objective Neutrophils contribute to the SLE pathogenesis. Neutrophil lymphocyte ratio (NLR) is reported correlate with disease activity in SLE. The aim of study was evaluate whether NLR reflects underlying immunopathogenic SLE, as well determine contribution each component NLR, neutrophil and count. Methods Data were obtained from a cohort patients (n=141) recruited at Lund University, Sweden. levels compared between healthy controls (n=79). relationship clinical immunological markers...
Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance. A hallmark SLE the presence autoantibodies resulting from B cell hyperactivity. Previous studies have shown that abnormal subsets in periphery, such as CD27highCD20- cells, correlate with disease activity. We examined relationship between expression CD70, ligand for CD27 expressed activated T and indicators significant increase median CD70+CD4+ frequencies memory CD45RA-CD4+ was observed samples compared to...
Objective. CD70-expressing CD4 T cells are enriched in RA and promote autoimmunity via co-stimulatory CD70-CD27 interaction. This study aimed to explore the phenotype cytokine production of CD70+ RA. Methods. Peripheral blood mononuclear from 32 patients were isolated frequencies within different subsets analysed using flow cytometry. IFN-γ IL-17 compared between CD70− cells. Expression master transcription factors T-bet, GATA3 retinoic acid–related orphan receptor gamma t (RORγt) examined...
To evaluate the relationship between chondrocalcinosis and pain or synovitis in knee joints by examining data from Osteoarthritis Initiative (OAI).Data were obtained OAI public-use sets. The on baseline radiograph at 4 years was examined. Analyses adjusted for age, sex, body mass index, Kellgren-Lawrence (K/L) grade correlation 2 knees a subject controlled using generalized estimating equations. magnetic resonance imaging (MRI) examined comparing with K/L grade-matched no chondrocalcinosis....
Despite the importance of early detection glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for diagnosis in Korea. Forty-two volunteers with/without open-angle were enrolled from January through October 2015—divided into a control or group, which was further divided normal-tension (NTG) and high-tension (HTG) groups—and underwent assessments myelin basic protein (MBP), heat shock 60, anti-Sjögren’s-syndrome-related antigen A (SSA) B...
Yachoui, Ralph MD; Kolasinski, Sharon L. Han, Bobby Kwanghoon MD Author Information
In Brief Polyarteritis nodosa (PAN) is a vasculitis of small- and medium-sized vessels, characterized by vascular aneurysms that can lead to ischemia infarction. We present the case patient with classic polyarteritis in abdominal organs who additionally demonstrated antitreponemal antiphospholipid antibodies, resulting severe cerebral thrombosis. This highlights: 1. The potential for false-positive syphilis serology PAN patients, 2. rare coexistence catastrophic syndrome. occasional...
<h3>Background</h3> CD70 expressing CD4 T cells are enriched in rheumatoid arthritis (RA) and promote autoimmunity via costimulatory CD70-CD27 interaction. To date, it is unknown whether CD70+ contribute to RA pathogenesis <i>via</i> other mechanisms than the <h3>Objectives</h3> explore phenotype cytokine production of RA. <h3>Methods</h3> Peripheral blood mononuclear (PBMCs) from 32 patients were isolated frequencies within different subsets analyzed using flow cytometry. Interferon (IFN)-γ...
From the Division of Rheumatology, Cooper Medical School Rowan University, Voorhees, NJ. The authors declare no conflict interest. Correspondence: Ralph Yachoui, MD, 900 Centennial Blvd Bldg 2 Ste 201, NJ 08043. E-mail: [email protected].
Liew, Jean W. MD; Struthers, Sarah A. Cormack, Fionnuala C. Bays, Alison M. MD, MPH&TM; Han, Bobby Kwanghoon MD Author Information
In the article by Bennett et al in September 2014 issue of Arthritis Care & Research (pages 1364–1373), text top section Figure 1 was omitted. The corrected appears below. We regret error.
<h3>Background</h3> The syndrome of incomplete lupus erythematosus (ILE) likely includes individuals at risk for development systemic (SLE). Studies interventions to lower or prevent further disease in ILE are interest. Design such trials will require methods classify patients and assess risk. goals the present study were evaluate performance updated SLE classification criteria define probe other features these that might be useful as indicators status. A long term goal is develop prognostic...
Liew, Jean W. MD∗; Struthers, Sarah A. MD†; Cormack, Fionnuala C. Bays, Alison M. MD, MPH&TM∗; Han, Bobby Kwanghoon MD∗ Author Information