A5027434200- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Ocular Diseases and Behçet’s Syndrome
- Biosimilars and Bioanalytical Methods
- Cutaneous lymphoproliferative disorders research
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Tryptophan and brain disorders
- Vasculitis and related conditions
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Tissue Engineering and Regenerative Medicine
Seoul National University Hospital
2001-2024
Seoul National University
2024
University of California, Davis
1998
Background Tissue-engineered heart valve leaflets are a promising way to overcome the inherent limitations of current prosthetic valves. The aim this study was compare biological responses an autologous cell seeded scaffold and acellular implanted in pulmonary leaflet same animal. Methods Myofibroblasts endothelial cells were isolated cultured from ovine artery. A synthetic biodegradable consisting polyglycolic acid polylactic initially with myofibroblasts, then coated cells. Cells using...
Junha Park, Min Soo Byun, Dahyun Yi, Hyejin Ahn, Joon Hyung Jung, Nayeong Kong, Yoon Young Chang, Gijung Jun-Young Lee, Yu Kyeong Kim, Yun-Sang Koung Mi Kang, Chul-Ho Sohn, Dong Lee; for the KBASE Research Group. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.24.1189
<h3>Background</h3> Bruton tyrosine kinase (BTK), a Tec family kinase, is involved in B cell activation and osteoclast formation. As BTK plays central role receptor (BCR) signaling development, might be an attractive therapeutic target for autoimmune diseases including rheumatoid arthritis (RA) [1–3]. <h3>Objectives</h3> To investigate the effects of HM7122, novel inhibitor, on human <h3>Methods</h3> In vitro biochemical inhibition assay was performed using Invitrogen assay. Peripheral blood...
<h3>Background</h3> The clinical importance of rheumatoid arthritis-associated interstitial lung disease has been increased because the usual pneumonia (UIP) is most common subtype (ILD) on high-resolution computed tomography (HRCT) in arthritis (RA)and poor survival rate compared to other forms ILD related connective tissue disease. <h3>Objectives</h3> characteristics and laboratory data RA patients with without were order clarify risk factors for patients. Furthermore, mortality group...
<h3>Background</h3> CD70 expressing CD4 T cells are enriched in rheumatoid arthritis (RA) and promote autoimmunity via costimulatory CD70-CD27 interaction. To date, it is unknown whether CD70+ contribute to RA pathogenesis <i>via</i> other mechanisms than the <h3>Objectives</h3> explore phenotype cytokine production of RA. <h3>Methods</h3> Peripheral blood mononuclear (PBMCs) from 32 patients were isolated frequencies within different subsets analyzed using flow cytometry. Interferon (IFN)-γ...
<h3>Background</h3> Takayasu arteritis (TA) affects the aorta and its major branches. The damage to arterial wall by chronic inflammation often results in vascular complications including aneurysm formation or luminal stenosis which can be benefited from interventions. <h3>Objectives</h3> aim of this study was investigate outcomes surgical percutaneous intervention identify factors associated with restenosis requiring a reintervention. <h3>Methods</h3> In retrospective study, patients TA...
<h3>Background</h3> Interstitial lung disease (ILD) is the most common cause of mortality in patients with dermatomyositis (DM). Cyclosporine has been reported to improve clinical outcome some DM-associated ILD. <h3>Objectives</h3> To investigate benefit early introduction cyclosporine on survival <h3>Methods</h3> All ILD, who were treated at Seoul National University Hospital (SNUH) and Bundang (SNUBH) between 1990 2013, enrolled. Enrolled diagnosed DM according Bohan-Peter9s classification...
<h3>Background</h3> Interstitial lung disease (ILD) is a common cause of death in patients with dermatomyositis (DM). Especially, clinically amyopathic DM (CADM) have worse outcome due to ILD which often refractory corticosteroids. Lung involvement as an additional target inflammation increases the total inflammatory burden DM. <h3>Objectives</h3> To investigate whether erythrocyte sedimentation rate (ESR) elevation associated and prognosis <h3>Methods</h3> All including CADM receiving...
<h3>Background</h3> Chemokines are multifunctional mediators that control leukocyte recruitment into the inflammatory sites and enhance immune responses. It remains to be investigated which chemokines important in Behcet9s disease (BD). <h3>Objectives</h3> The objective of this study was investigate serum levels neutrophil lymphocyte chemoattractants BD patients its association with activity symptoms. <h3>Methods</h3> We collected sera from (n=64) age-, sex matched healthy controls (n=21)....
<h3>Background</h3> Osteoarthritis (OA) in the hand often associates with considerable disability and a reduced quality of life that is comparable to effects rheumatoid arthritis. GCSB-5 mixture six purified oriental herb extracts, which have anti-inflammatory, analgesic, chondroprotective effects. <h3>Objectives</h3> To investigate efficacy safety for treating OA, prospective, double-blind, placebo-controlled, randomized, multicenter trial was conducted. <h3>Methods</h3> Patients OA who had...
<h3>Background</h3> Since 2004, Korean national health insurance began to cover the cost of biologic agents in rheumatoid arthritis (RA) patients experiencing treatment failure by conventional disease modifying antirheumatic agents. However, real-world issues such as selecting or switching among clinical practice became more complicated types increased. <h3>Objectives</h3> To evaluate 1) first choice agents, 2) drug retention rate and duration 3) before each agent RA. <h3>Methods</h3> We...
<h3>Background</h3> Adult onset of Still9s disease (AOSD) is a systemic inflammatory characterized by fever, arthritis, salmon pink rash and elevated serum markers. The classical fever AOSD intermittent with quotidian or double-quotidian pattern. However, significant subset exhibits persistently high little temperature fluctuation. It remains unclear as to whether the certain pattern associated specific clinical manifestations. <h3>Objectives</h3> To investigate association between...
<h3>Background</h3> Patients with systemic lupus erythematosus (SLE) are at an increased risk of developing a cardiovascular disease which not solely explained by the traditional (CV) factors. This higher CV might be associated chemical and functional alteration lipoproteins in SLE patients. <h3>Objectives</h3> study aimed to investigate lipoprotein modification from patients its effects on oxidative stress <i>in vivo</i> vitro</i>. <h3>Methods</h3> A total 35 15 age sex matched heathy...
<h3>Background</h3> Measuring severity of interstitial lung disease (ILD) usually depends on the extent or pattern imaging findings computed tomography (CT) and parameters pulmonary function test. Krebs von den Lungen 6 (KL-6) is a sialylated glycoprotein mainly expressed surface membrane type II pneumocytes bronchiolar epithelial cells. Serum level KL-6 had been reported to be associated with presence outcome ILD connective tissue diseases (CTD-ILD). <h3>Objectives</h3> We aimed evaluate as...