A5083642653- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Mast cells and histamine
- Vasculitis and related conditions
- Musculoskeletal synovial abnormalities and treatments
- Eosinophilic Disorders and Syndromes
- Primary Care and Health Outcomes
- Orthopedic Infections and Treatments
- Dermatologic Treatments and Research
- Infectious Diseases and Tuberculosis
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Celiac Disease Research and Management
- Extracellular vesicles in disease
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Skin Diseases and Diabetes
- Renal Diseases and Glomerulopathies
- Occupational exposure and asthma
Soonchunhyang University
2015-2025
Brigham and Women's Hospital
2024-2025
Harvard University
2025
Seoul National University
1987-2024
Center for Rheumatology
2024
Soonchunhyang University Hospital
2015-2023
Chungnam National University
2018
Seoul St. Mary's Hospital
2018
Seoul National University Bundang Hospital
2014-2018
National University College
2015-2018
Objective To investigate baseline and change of pulmonary damage biomarkers (serum Krebs von den Lungen 6 [KL-6], human surfactant protein D [hSP-D], matrix metalloproteinase 7 [MMP-7]) with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) progression. Methods In the Korean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) cohort, a prospective we enrolled patients RA ILD confirmed by chest computed tomography imaging followed annually. progression was defined as...
To explore the course of lung function and RA disease activity predictive factors for deteriorating in patients with RA-interstitial (ILD).The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients RA-ILD were enrolled followed up annually 3 years ILD status assessment. Group-based modelling was used to cluster similar predicted percentage forced vital capacity (FVC%) patterns into trajectories.This study included 140 who...
Abstract Introduction Rheumatic diseases (RDs) are associated with different cancers; however, it is unclear whether particular cancers more prevalent in certain RDs. In the present study, we examined relative incidence of several a single homogeneous cohort patients Methods Patients ( N = 3,586) diagnosed rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), sclerosis (SSc), dermatomyositis (DM) or polymyositis were included. Cancer diagnosis was based on histopathology. The 2008...
Background/Objectives: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) significantly affects prognosis and patient survival. The impact of conventional synthetic DMARDs (csDMARDs) biologic/targeted (b/tsDMARDs) on RA-ILD prognoses remains unclear. This study aimed to investigate the effects csDMARDs b/tsDMARDs progression based pulmonary function tests (PFTs), high-resolution computed tomography (HRCT), symptom changes. Methods: multicenter, retrospective, observational...
Abstract Objective To examine the association between MTX, LEF and tacrolimus use progression of RA-associated interstitial lung disease (ILD). Methods The Korean RA-ILD cohort prospectively enrolled patients with ILD at multiple centres from 2015 to 2018 followed up them for 3 years. was defined by any followings: a decrease ≥10% in forced vital capacity, ≥15% diffusing capacity carbon monoxide, or death respiratory failure. Results Of 143 patients, 64 experienced during median follow-up...
To compare the outcomes of gastric, colon, lung, and breast cancer patients with without rheumatic diseases (RD).This retrospective study compared survival rates a cohort 122 rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), dermatomyositis/polymyositis (DM/PM), or sclerosis that 366 age-, sex-, and, type-matched RD who received medical care from 2000 to 2014. Staging, comorbidities, functional status were ascertained. Survival was using Kaplan-Meier method. Relative risk death...
We aimed to evaluate the prevalence of foot and/or ankle arthritis (FAA) and its impact on clinical indices in patients with rheumatoid (RA).This cross-sectional study used data from Korean College Rheumatology Biologics & Targeted therapy registry observe outcomes undergoing biologics conventional therapy. FAA was defined as ≥1 tender or swollen joint 1st-5th metatarsophalangeal (MTP) joints. Disease Activity Score 28 (DAS28), Routine Assessment Patient Index Data 3 (RAPID3), Simplified...
Diffuse alveolar hemorrhage (DAH) is a rare but devastating complication of systemic lupus erythematosus (SLE) with high early mortality rate. DAH seldom occurs without active organ involvement. Recently, rituximab (RTX), B cell-targeted therapy, has been reported to be effective for life-threatening autoimmune diseases. We describe SLE patient who presented acute respiratory failure due other This condition was dramatically improved RTX cyclophosphamide.
Background/Aims To investigate the rate of detection monosodium urate (MSU) crystals in synovial fluid (SF) patients with acute gouty arthritis and factors associated false-negative results. Methods A total 179 who had undergone SF crystal examination were identified from data warehouse two university hospitals. Clinical laboratory obtained medical records. Results The overall MSU was 78.8%. In univariate analyses, only significant differences between variables crystal-negative...
We aimed to investigate demographic and clinical features predictors of mortality in Korean patients with systemic sclerosis (SSc).We performed a retrospective multicenter medical chart review diagnosed SSc from 1986 2016 at 11 university hospitals representing each geographic area Korea. were defined according the American College Rheumatology preliminary classification criteria subtyped as limited cutaneous (lcSSc) or diffuse (dcSSc) SSc.We enrolled 751 (female, 86.7%; mean age diagnosis,...
Background: Although microbes have been suggested to play a role in the pathogenesis of ankylosing spondylitis (AS), several studies present contradictory results regarding association between AS and chronic periodontitis (CP). Methods: Clinical, laboratory, medication data were collected from 84 patients with age‐ sex‐matched controls. Periodontal measurements, including probing depths (PDs), clinical attachment loss (AL), serum anti‐ Porphyromonas gingivalis titers, detection P. DNA...
The present study aimed to investigate the clinical implication of F-18 sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) for assessing disease activity rheumatoid arthritis.Seventeen patients with arthritis according 2010 American College Rheumatology/European League Against Rheumatism classification criteria were prospectively enrolled. All enrolled underwent NaF PET/CT along physical examination, blood test, and ultrasonography. On images, two quantitative...
The increase in mortality rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) is well known However, there are few studies on serum markers that can evaluate acute exacerbation or prognosis RA-ILD purpose of this study was to identify the association between biomarkers and lesions RA-ILD.We analyzed 153 samples a prospective, multicenter cohort Korean levels biomarkers, matrix metalloproteinase (MMP-7), surfactant protein-D (SP-D), Krebs von den Lungen-6 (KL-6) were...
Abstract Background Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease (ILD) featuring dense fibrosis of the visceral pleura and subpleural parenchyma, mostly in upper lobes. PPFE can present other ILDs, including rheumatoid arthritis-associated ILD (RA-ILD). The aim this retrospective study was to investigate prevalence clinical implications coexistent RA-ILD. Methods Overall, 477 patients with RA-ILD were recruited from two cohorts; their data HRCT images analysed....