A5081306729- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Intracranial Aneurysms: Treatment and Complications
- Vector-borne infectious diseases
- Sarcoidosis and Beryllium Toxicity Research
- Hepatitis C virus research
- Cerebrovascular and Carotid Artery Diseases
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Vectors
- Traumatic Brain Injury and Neurovascular Disturbances
- Biosimilars and Bioanalytical Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mosquito-borne diseases and control
- HER2/EGFR in Cancer Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Disease Management Strategies
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
Boston University
2013-2024
Bristol-Myers Squibb (Germany)
2023
Eli Lilly (United States)
2023
Janssen (Belgium)
2023
Ragon Institute of MGH, MIT and Harvard
2023
Mallinckrodt (Ireland)
2023
Amgen (United States)
2023
Johnson & Johnson (Brazil)
2023
Interstitial lung disease (ILD), a leading cause of morbidity and mortality in rheumatoid arthritis (RA), is highly prevalent, yet RA-ILD underrecognized.To identify clinical risk factors, autoantibodies, biomarkers associated with the presence RA-ILD.Subjects enrolled Brigham Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) American College Rheumatology (ACR) cohorts were evaluated for ILD. Regression models used to assess association between variables interest RA-ILD....
To evaluate rheumatoid arthritis (RA) disease activity and risk of RA-associated interstitial lung (RA-ILD).We investigated RA-ILD using the Brigham RA Sequential Study (BRASS, 2003-2016). All patients were diagnosed as having according to accepted criteria. Disease Activity Scores in 28 joints (DAS28) covariate data measured prospectively at annual study visits. Diagnosis was determined by review images from clinically indicated chest computed tomography scans. We analyzed without baseline....
Objective: To ascertain the prevalence of and risk factors for long-term sequelae from acute Lyme disease. Design: Population-based, retrospective cohort study. Setting: A coastal region endemic Participants: Patients with a history disease who were previously treated antibiotics compared randomly selected controls. Measurements: standardized physical examination, health status measure (Short Form 36), psychometric test battery, serologic analysis. Results: Compared control group (n = 43),...
Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in RA patients according to Activity Score (DAS28-CRP4) and American College Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria.Data were analyzed from Brigham Rheumatoid Arthritis Sequential Study with data at baseline 1 year. DAS28 was defined DAS28-CRP4 <2.6. The...
To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA).
Quantitative assessment of disease activity in rheumatoid arthritis (RA) is important for patient management, and additional objective information may aid rheumatologists clinical decision making. We validated a recently developed multibiomarker (MBDA) test relative to diverse RA cohorts.Serum samples were obtained from the Index Rheumatoid Arthritis Measurement, Brigham Women's Hospital Sequential Study, Leiden Early Clinic cohorts. Levels 12 biomarkers measured combined according...
Background Disease activity measurement is a key component of rheumatoid arthritis (RA) management. Biomarkers that capture the complex and heterogeneous biology RA have potential to complement clinical disease assessment. Objectives To develop multi-biomarker (MBDA) test for arthritis. Methods Candidate serum protein biomarkers were selected from extensive literature screens, bioinformatics databases, mRNA expression microarray data. Quantitative assays identified optimized measuring...
Objectives One goal of remission in rheumatoid arthritis (RA) is to halt joint damage. The authors assessed the progression radiographic damage among RA patients by new ACR/EULAR criteria (Boolean approach) compared with thresholds for simplified disease activity index (SDAI), clinical (CDAI) and score based on 28 joints C-reactive protein (DAS28-CRP) an observational cohort, evaluated relationship between time Methods 535 underwent physical examination laboratory assessment at baseline, 1 2...
Although smoking is a known risk factor for intracranial aneurysm (IA) rupture, the exact relationship between IA rupture and intensity duration, as well duration of cessation, remains unknown.In this case-control study, we analyzed 4,701 patients with 6,411 IAs diagnosed at Brigham Women's Hospital Massachusetts General 1990 2016. We divided individuals into ruptured aneurysms controls unruptured aneurysms. performed univariable multivariable logistic regression analyses to determine...
Objective Among patients with rheumatoid arthritis (RA), pain may be attributed to peripheral inflammation or other causes, such as central mechanisms. The aim of this study was use self‐report measures and physical examination findings identify clusters RA who have different causes well prognoses treatment options. Methods Data from 169 scores >0 (on a 10‐point numeric rating scale) in the Brigham Women's Hospital Rheumatoid Arthritis Sequential Study were analyzed. completed...
To use natural language processing (NLP) in conjunction with the electronic medical record (EMR) to accurately identify patients cerebral aneurysms and their matched controls.ICD-9 Current Procedural Terminology codes were used obtain an initial data mart of potential aneurysm from EMR. NLP was then train a classification algorithm .632 bootstrap cross-validation for correction overfitting bias. The rule applied full mart. Additional validation performed on 300 classified as having...
Objective To determine the association between novel lifestyle factors on risk of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD), define threshold at which smoking increases RA-ILD risk, and calculate degree to known clinical predict RA-ILD. Methods This nested case-control study matched incident cases RA non-ILD controls age, sex, duration, factor, time from exposure assessment Exposures included education, BMI, smoking, anticyclic citrullinated peptide antibodies,...
Background: Previous follow-up studies of patients with Lyme disease suggest that disseminated infection may be associated long-term neurologic and musculoskeletal morbidity. Objective: To determine clinical functional outcomes in persons who were treated for the late 1980s. Design: Population-based, retrospective cohort study. Setting: Nantucket Island, Massachusetts. Participants: 186 had a history (case-patients) 167 did not (controls). Measurements: Standardized medical history, physical...
Abstract Objective To examine the association of biomarkers inflammation with preclinical rheumatoid arthritis (RA). Methods A nested case–control study was performed using samples from 2 large, prospectively studied cohorts women (the Women's Health Study [WHS] and Nurses' [NHS]). Blood obtained prior to symptom onset in who later developed RA were selected as incident cases, 3 controls per case randomly chosen, matched for age, menopausal status, postmenopausal hormone use, day, time,...
Anti-tumor necrosis factor alpha (anti-TNF) therapy is a mainstay of treatment in rheumatoid arthritis (RA). The aim the present study was to test established RA genetic risk factors determine whether same alleles also influence response anti-TNF therapy.A total 1,283 patients receiving etanercept, infliximab, or adalimumab were studied from among an international collaborative consortium 9 different cohorts. primary end point compared with good according European League Against Rheumatism...