A5020538003- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Spinal Hematomas and Complications
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- Vascular Malformations Diagnosis and Treatment
- Vascular Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Fetal and Pediatric Neurological Disorders
- Pituitary Gland Disorders and Treatments
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Vascular anomalies and interventions
- Craniofacial Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cleft Lip and Palate Research
- Migraine and Headache Studies
- Aortic aneurysm repair treatments
- Neurological Complications and Syndromes
Erasmus University Rotterdam
2014-2024
Erasmus MC
2015-2024
Erasmus MC - Sophia Children’s Hospital
2013-2024
Stroke Association
2023
Leiden University Medical Center
2021-2022
Decision Sciences (United States)
2022
Harvard University
2015-2022
University of Michigan
2022
University Medical Center Utrecht
2022
Utrecht University
2022
Induced hypertension is widely used to treat delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but a literature review shows that its presumed effectiveness based on uncontrolled case-series only. We here report clinical outcome of hemorrhage patients with DCI included in randomized trial the induced hypertension.Aneurysmal symptoms were or no hypertension. Risk ratios for poor (modified Rankin Scale score >3) at 3 months, 95% confidence intervals, calculated and...
The role of glucocorticoids without surgical evacuation in the treatment chronic subdural hematoma is unclear.In this multicenter, open-label, controlled, noninferiority trial, we randomly assigned symptomatic patients with a 1:1 ratio to 19-day tapering course dexamethasone or burr-hole drainage. primary end point was functional outcome at 3 months after randomization, as assessed by score on modified Rankin scale (range, 0 [no symptoms] 6 [death]). Noninferiority defined lower limit 95%...
Computerized tomography (CT) scanning provides an objective assessment of the structural damage to brain following traumatic injury (TBI). We aimed describe and quantify relationship between CT characteristics 6-month outcome, assessed by Glasgow Outcome Scale (GOS). Individual patient data from IMPACT database were available on classification (N = 5209), status basal cisterns ( N 3861), shift 4698), subarachnoid hemorrhage (tSAH) 7407), intracranial lesions 7613). used binary logistic...
Although smoking is a known risk factor for intracranial aneurysm (IA) rupture, the exact relationship between IA rupture and intensity duration, as well duration of cessation, remains unknown.In this case-control study, we analyzed 4,701 patients with 6,411 IAs diagnosed at Brigham Women's Hospital Massachusetts General 1990 2016. We divided individuals into ruptured aneurysms controls unruptured aneurysms. performed univariable multivariable logistic regression analyses to determine...
♦ Objective Hypertension, reduced arterial distensibility, and left ventricular hypertrophy (LVH) are risk factors for mortality in hemodialysis patients. However, few studies have focused on the relation between fluid status, blood pressure (BP), cardiovascular abnormalities peritoneal dialysis (PD) This study was designed, first, to assess, using tracer dilution techniques, status PD patients compared a control population of stable renal transplant (RTx) patients; second, BP, wall...
Previously, we reported on our single centre results regarding the diagnostic yield of stereotactic needle biopsies brain lesions. The then (1996–2006) was 89.4%. In present study, review and evaluate experience with intraoperative frozen-section histopathologic diagnosis on-demand in order to improve yield. One hundred sixty-four consecutive frameless biopsy procedures 160 patients (group 1, 2006–2010) were compared historic control group 2, n = 164 procedures). Diagnostic yield, as well...
Chronic subdural hematoma (CSDH) is commonly seen in neurosurgical practice, and the incidence increasing. Treatment results are highly variable with respect to recurrences complications.To report our single-center experience surgical treatment of CSDH patients on preoperative corticosteroids assess possible predictors outcome.The medical reports 496 consecutive CSDHs treated burr hole craniostomy were analyzed retrospectively. Patient demographics, medication, hematoma, characteristics,...
The presumed effectiveness of induced hypertension for treating delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage is based on uncontrolled case-series only. We assessed the effect blood flow (CBF) in patients with a randomized clinical trial.Aneurysmal were to or no (control group) at onset. CBF was assessed, blinded treatment allocation, computed tomographic perfusion standardized predefined regions onset and 24 36 hours study treatment. Mean arterial pressure compared...
Multiple drugs targeting the calcitonin gene-related peptide (CGRP) receptor have been developed for migraine treatment. Here, effect of monoclonal antibody erenumab on CGRP-induced vasorelaxation was investigated in human isolated blood vessels, as well combining with small molecule drugs, namely rimegepant, olcegepant, or sumatriptan.
Background Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a involved in migraine pathophysiology, differ between men women, appear to be affected by changes sex hormones. The present study investigated the sex-specific responses CGRP human isolated arteries. Methods CGRP-induced relaxation 62 (28 34 women) middle meningeal arteries (HMMA) 139 (69 70 coronary (HCA) was compared women groups <50 years ≥50 age as proxy for pre- postmenopausal status well...
Purpose To compare the diagnostic performance of minimally invasive autopsy with that conventional autopsy. Materials and Methods For this prospective, single-center, cross-sectional study in an academic hospital, 295 2197 adult cadavers (mean age: 65 years [range, 18-99 years]; age range male cadavers: years; female 18-98 years) who died from 2012 through 2014 underwent Family consent for was obtained 139 cadavers; 99 those were included study. Those involved blinded to each other's...
Spinal intradural tumors can be classified as extramedullary or intramedullary tumors. meningiomas are among the most frequent intradural, (IDEMs), representing 12 % of all and 25–45 spinal To evaluate postoperative outcome, defined by mortality, tumor recurrence modified Rankin Scale in patients with meningiomas. Furthermore, to identify factors related these outcome measures define possible prognosticators. A large single center retrospective analysis 166 consecutive meningioma during a...
Abstract Background Previous randomised controlled trials could not demonstrate that surgical evacuation of intracerebral haemorrhage (ICH) improves functional outcome. Increasing evidence suggests minimally invasive surgery may be beneficial, in particular when performed early after symptom onset. The aim this study was to investigate safety and technical efficacy endoscopy-guided patients with spontaneous supratentorial ICH. Methods Dutch Intracerebral Haemorrhage Surgery Trial pilot a...