Mathieu van der Jagt
A5051621488- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
- Intracranial Aneurysms: Treatment and Complications
- Anesthesia and Sedative Agents
- Neurosurgical Procedures and Complications
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Cerebrospinal fluid and hydrocephalus
- Family and Patient Care in Intensive Care Units
- Healthcare Decision-Making and Restraints
- Thermal Regulation in Medicine
- Hemodynamic Monitoring and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Long-Term Effects of COVID-19
- Takotsubo Cardiomyopathy and Associated Phenomena
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Organ Donation and Transplantation
- Music Therapy and Health
Erasmus MC
2016-2025
Erasmus University Rotterdam
2014-2025
Medisch Centrum Haaglanden
2025
University of Milano-Bicocca
2022
University of Antwerp
2022
University of Cambridge
2021-2022
Addenbrooke's Hospital
2022
University of Groningen
2016-2022
Antwerp University Hospital
2022
Innsbruck Medical University
2020-2021
Induced hypertension is widely used to treat delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but a literature review shows that its presumed effectiveness based on uncontrolled case-series only. We here report clinical outcome of hemorrhage patients with DCI included in randomized trial the induced hypertension.Aneurysmal symptoms were or no hypertension. Risk ratios for poor (modified Rankin Scale score >3) at 3 months, 95% confidence intervals, calculated and...
Importance Blood transfusions are commonly administered to patients with acute brain injury. The optimal hemoglobin transfusion threshold is uncertain in this patient population. Objective To assess the impact on neurological outcome of 2 different thresholds guide red blood cell Design, Setting, and Participants Multicenter, phase 3, parallel-group, investigator-initiated, pragmatic, open-label randomized clinical trial conducted 72 intensive care units across 22 countries. Eligible had...
No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential benefits risks of different pressure (ICP) management strategies, resulting practice variation. The aim this study was to examine variation monitoring treatment policies for TBI.A 29-item survey ICP developed the basis literature expert opinion, it pilot-tested 16 centers....
Abstract Background The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy safety. We sought to determine whether when compared placebo in critically ill adults with reduces days coma improves delirium-related sequelae. Methods This multi-center double-blind, placebo-controlled randomized trial at eight mixed medical-surgical Dutch ICUs included (Intensive Care Delirium Screening...
The use of arterial partial pressure carbon dioxide (PaCO2) as a target intervention to manage elevated intracranial (ICP) and its effect on clinical outcomes remain unclear. We aimed describe targets for PaCO2 in acute brain injured (ABI) patients assess the occurrence abnormal values during first week intensive care unit (ICU). secondary aim was association with in-hospital mortality. carried out analysis multicenter prospective observational study involving adult invasively ventilated...
The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and moderate TBI who deteriorate require admission the intensive care unit for intracranial pressure (ICP) management.
Abstract Background Sepsis and septic shock are significant global healthcare challenges with high mortality rates. Effective management requires timely adequate antimicrobial therapy. Beta-lactam antibiotics, commonly used in patients sepsis, crucial for treating these infections. However, standard dosing often leads to insufficient plasma levels due dynamic physiological changes critically ill patients. Previous randomized controlled trials highlighted the need dose adjustments improve...
To assess whether cardiac abnormalities after aneurysmal subarachnoid hemorrhage (aSAH) are associated with delayed cerebral ischemia (DCI) and clinical outcome, independent from known risk factors for these outcomes.In a prospective, multicenter cohort study, we performed echocardiography ECG measured biochemical markers myocardial damage in patients aSAH. Outcomes were DCI, death, poor outcome (death or dependency activities of daily living) at 3 months. With multivariable Poisson...
The presumed effectiveness of induced hypertension for treating delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage is based on uncontrolled case-series only. We assessed the effect blood flow (CBF) in patients with a randomized clinical trial.Aneurysmal were to or no (control group) at onset. CBF was assessed, blinded treatment allocation, computed tomographic perfusion standardized predefined regions onset and 24 36 hours study treatment. Mean arterial pressure compared...
ABSTRACT Background Delirium is a common form of vital organ dysfunction in intensive care unit (ICU) patients and associated with poor outcomes. Adherence to guideline recommendations pertaining delirium still suboptimal. Aims We performed survey aimed at identifying barriers for implementation that should be addressed tailored intervention targeted improved ICU adherence. Design The was conducted among professionals. Methods An online 360 health professionals (nurses, physicians...
Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use early preventive strategies and stratification ICU patients by risk clinical research, but optimal model to is unclear. We compared predictive performance user convenience for (PRE-DELIRIC) (E-PRE-DELIRIC) determined value a two-stage calculation.This 7-country, 11-hospital, prospective cohort study evaluated consecutive adults admitted who could be reliably assessed using Confusion Assessment...
Respiratory insufficiency occurs in 20 % of Guillain–Barré syndrome (GBS) patients, and the duration mechanical ventilation (MV) ranges widely. We identified predictors prolonged MV to guide clinical decision-making on tracheostomy. analyzed prospectively collected data from 552 patients with GBS context two trials three cohort studies The Netherlands. Potential for MV, defined as ≥14 days, were considered using crosstabs. Selected Cox regression analysis. On a total 150 (27 %) requiring 106...
In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting too early could result death despite the possibility an acceptable functional outcome, whereas delaying unnecessarily burden patients, families, clinicians, and hospital resources. We aimed to describe occurrence timing WLSM, factors associated European ICUs traumatic injury (TBI). The CENTER-TBI Study prospective multi-center...
Abstract Background Although blood transfusions can be lifesaving in severe hemorrhage, they also have potential complications. As anemia has been associated with poor outcomes critically ill patients, determining an optimal transfusion trigger is a real challenge for clinicians. This even more important patients acute brain injury who were not specifically evaluated previous large randomized clinical trials. Neurological may particularly sensitive to anemic hypoxia because of the exhausted...
Abstract Acute brain injuries, such as traumatic injury and ischemic hemorragic stroke, are a leading cause of death disability worldwide. While characterized by clearly distict primary events—vascular damage in strokes biomechanical injuries—they share common secondary mechanisms influencing long-term outcomes. Growing evidence suggests that more personalized approach to optimize energy substrate delivery the injured prognosticate towards families could be beneficial. In this context,...