A5084129737- Cell death mechanisms and regulation
- Pancreatic and Hepatic Oncology Research
- GaN-based semiconductor devices and materials
- Cancer Genomics and Diagnostics
- Functional Brain Connectivity Studies
- Cancer Cells and Metastasis
- Semiconductor materials and devices
- Phagocytosis and Immune Regulation
- Genetic factors in colorectal cancer
- Schizophrenia research and treatment
- MicroRNA in disease regulation
- Ga2O3 and related materials
- Recycling and Waste Management Techniques
- NF-κB Signaling Pathways
- Cancer Research and Treatments
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- ZnO doping and properties
- Ferroelectric and Piezoelectric Materials
- Colorectal Cancer Surgical Treatments
- Semiconductor Quantum Structures and Devices
- Psychosomatic Disorders and Their Treatments
- Metal and Thin Film Mechanics
- Colorectal Cancer Treatments and Studies
- Mental Health and Psychiatry
University Hospital Schleswig-Holstein
2012-2024
University of Lübeck
2012-2024
Fraunhofer Institute for Integrated Systems and Device Technology
2024
Kiel University
2003-2024
University of Tübingen
2023-2024
TU Bergakademie Freiberg
2015-2024
University Medical Center Utrecht
2020-2023
Utrecht University
2020-2023
Schön Klinik Hamburg Eilbek
2018-2022
Institute of Clinical Cancer Research
2017
Background Body image distortion is a key symptom of anorexia nervosa. In behavioral research two components body have been defined: attitudes towards the and size experience. Neuroimaging studies concerning own distortions in nervosa revealed an inconsistent pattern results are constrained by fact that no direct distinction between different parts has made. Method The present study therefore set out to investigate neural correlates using functional magnetic resonance imaging (fMRI):...
The dissemination of cancer cells is a prerequisite in the development micrometastases and solid metastases. Our previous examinations these were based on immunocytological staining tumor-associated antigens cytokeratins. We have now developed highly sensitive specific detection method nested reverse-transcriptase-polymerase-chain reaction (RT-PCR) cytokeratin-20 (CK-20) mRNA. Using this method, we examined bone marrow 57 patients with colorectal detected increasing numbers CK-20-positive...
Sentinel lymph node (SN) biopsy is part of the staging procedure in breast cancer patients. In this study, we compared an intraoperative tool named one-step nucleic acid amplification (OSNA) to our routine histological investigation. OSNA consists a short homogenization step followed by cytokeratin (CK) 19 mRNA directly from lysate. To evaluate performance comparison histology, analysis 343 axillary nodes (ALN) 93 patients was performed with both methods. Discordant samples were subjected...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive stroma being also present in chronic pancreatitis (CP). Using immunohistochemistry, the of CP and PDAC was comprehensively analyzed correlated with epithelial/carcinoma-related alterations clinicopathological patient characteristics. While there were no significant differences between regarding distribution CD3+ T cells α-SMA+ fibroblasts, proportions CD4+ CD8+ significantly lower numbers CD25+(CD4+) FoxP3+(CD4+)...
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through endothelial layer blood vessels escape hostile circulation and establish metastases at distant organ sites. Here, we identified membrane-bound metalloprotease ADAM17 on as a key driver metastasis. We show that TNFR1-dependent cell–induced cell death, extravasation, subsequent metastatic seeding dependent activity ADAM17. Moreover, reveal ADAM17-mediated TNFR1 ectodomain shedding...
Polymers represent around 25% of total waste from electronic and electric equipment. Any successful recycling process must ensure that polymer-specific functionalities are preserved, to avoid downcycling. This requires a precise characterization particle compounds moving at high speeds on conveyor belts in processing plants. We present an investigation using imaging point measurement spectral sensors 23 polymers including ABS, PS, PC, PE-types, PP, PVC, PET-types, PMMA, PTFE assess their...
Pancreatic adenocarcinoma represents a tumor type with extremely poor prognosis. High apoptosis resistance and strong invasive early metastatic potential contribute to its highly malignant phenotype. Here we identified the death receptor adaptor molecule TRAF2 as key player in pancreatic cancer pathophysiology. Using immunohistochemistry Western blot analysis found overexpressed 34 of 36 samples well cell lines resistant CD95-mediated apoptosis. The high protein level was not related...
<i>Background:</i> Depersonalization (DP) is characterized by persistent or recurrent episodes of detachment from one’s self with reduced pain perception being a common feature. Alterations in the body schema similar to cortico-limbic disconnection syndrome asymbolia are suggested be responsible for DP. In this study we used hypnosis induce DP healthy subjects and examine neural patterns state means functional magnetic resonance imaging (fMRI). <i>Methods:</i> Pain...
In recent years, special interest has been focused on impairments of executive functions in patients with obstructive sleep apnoea syndrome (OSAS). However, the majority studies have not clearly separated deficits from other cognitive processes involved task solving. present study, working memory (WM) 20 OSAS were compared those 10 age-, sex- and education-matched healthy subjects. Cognitive measured four times a day; each these measurements was accompanied by an assessment subjective...
Background Recent studies have suggested that deregulated AKT1 signaling is associated with schizophrenia. We hypothesized if this indeed the case, we should observe both decreased expression as well deregulation of regulated pathways in Peripheral Blood Mononuclear Cells (PBMCs) schizophrenia patients. Objectives To examine PBMC levels patients versus controls, and to whether functional biological processes which plays an important role are Methods/Results A case-control study,...
Abstract Background The cytokine TRAIL represents one of the most promising candidates for apoptotic elimination tumor cells, either alone or in combination therapies. However, its efficacy is often limited by intrinsic acquired resistance cells to apoptosis. Programmed necrosis an alternative, molecularly distinct mode programmed cell death that elicited under conditions when classical apoptosis machinery fails actively inhibited. potential TRAIL-induced therapy is, however, almost...
Highly insulating layers are a prerequisite for gallium nitride (GaN)‐based power electronic devices. For this purpose, carbon doping is one of the currently pursued approaches. However, its impact on optical and electrical properties GaN has been widely debated in scientific community. further improvement device performance, better understanding role related defects essential. To study optically active point defects, photoluminescence most frequently used experimental characterization...