A5085847246- Advanced Chemical Physics Studies
- Speech Recognition and Synthesis
- Cell death mechanisms and regulation
- Semiconductor Quantum Structures and Devices
- Surface and Thin Film Phenomena
- Music and Audio Processing
- Speech and Audio Processing
- Cellular transport and secretion
- GaN-based semiconductor devices and materials
- Lipid Membrane Structure and Behavior
- Quantum and electron transport phenomena
- Semiconductor materials and devices
- Natural Language Processing Techniques
- NF-κB Signaling Pathways
- Electronic and Structural Properties of Oxides
- Immune Cell Function and Interaction
- Antimicrobial Resistance in Staphylococcus
- Erythrocyte Function and Pathophysiology
- interferon and immune responses
- Ga2O3 and related materials
- Phagocytosis and Immune Regulation
- Speech and dialogue systems
- Receptor Mechanisms and Signaling
- Antibiotic Resistance in Bacteria
- CAR-T cell therapy research
University Hospital Regensburg
2021-2025
Hospital IPO
2023
University Hospital Schleswig-Holstein
2013-2022
University of Lübeck
2013-2022
University of Regensburg
1998-2021
Kiel University
2010-2021
Karlsruhe Institute of Technology
1998-2012
University of Kassel
2003
Carnegie Mellon University
1996-2002
Arizona State University
1997-1999
Improvements to the Sankey-Niklewaki method [O. F. Sankey and D. J. Niklewski, Phys. Rev. B 40, 3979 (1989)] for computing total energies forces, within an ab initio tight-binding formalism, are presented here. In particular, improved (called FIREBALL) uses separable pseudopotential (Hamann or Troullier) goes beyond minimal ${\mathrm{sp}}^{2}$ basis set of Sankey-Niklewski method, allowing double numerical sets with addition polarization orbitals d set. A major improvement includes use more...
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through endothelial layer blood vessels escape hostile circulation and establish metastases at distant organ sites. Here, we identified membrane-bound metalloprotease ADAM17 on as a key driver metastasis. We show that TNFR1-dependent cell–induced cell death, extravasation, subsequent metastatic seeding dependent activity ADAM17. Moreover, reveal ADAM17-mediated TNFR1 ectodomain shedding...
Cell death induced by tumor necrosis factor (TNF) can be beneficial during infection helping to mount proper immune responses. However, TNF-induced also drive a variety of inflammatory pathologies. Protectives brakes, or cell-death checkpoints, normally repress TNF cytotoxicity protect the organism from its potential detrimental consequences. Thus, although kill, this only occurs when one checkpoints is inactivated. Here, we describe checkpoint that prevents apoptosis through detoxification...
In most of Europe and especially in Germany, there is currently a concerning rise the number hospital-acquired infections due to vancomycin-resistant Enterococcus faecium (VREfm). Therefore, need improve our understanding way VREfm spreads hospitals. this study, we investigated molecular epidemiology isolates from first appearance at university hospital 2004 until 2010. There only very scarce information about early time Germany. Our analysis includes all available each patient tertiary care...
In treating cancer, immunotherapy has been established as a later-line treatment option in clinical practice. That includes stem cell transplantation, modified or activated immune cells, and antibodies directed against aberrant cells. As an unconventional subgroup, γδ T cells have shown to provide effects malignant They exhibit MHC-independent activation process, which could diminish graft-versus-host disease after adoptive transfer of allogeneic Over the last years, efficacy therapeutic...
We have investigated the stoichiometry and atomic electronic structure of anion- cation-terminated (0001) surfaces wurtzite-phase GaN AlN, using ab initio local-orbital calculations based on local-density approximation pseudopotential method. All stable surface configurations studied differ in composition periodicity from ideal bulklike termination. compare total energy computed for various $p(2\ifmmode\times\else\texttimes\fi{}2)$ geometries AlN(0001). Vacancy structures are found to be...
Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce either cell survival or death. The selection between these diametrically opposed effects depends on the subcellular location TNF-R1: plasma membrane retention leads survival, while endocytosis How respective TNF-R1 associated signaling complexes are recruited distinct is not known. Here, we identify palmitoylation as a molecular mechanism achieve signal diversification.Human monocytic U937 cells were analyzed....
We have investigated the dynamics of relaxed GaAs(110) surface using an ab initio linear-response approach in framework density-functional theory. The relaxation geometry was found by minimizing total energy with help Hellmann-Feynman forces. In terms electronic ground-state properties we calculated full phonon dispersion along high symmetry lines Brillouin zone means a self-consistent first-order perturbation scheme without any adjustable parameters. Our results are excellent agreement all...
Signaling by tumor necrosis factor (TNF) receptor 1 (TNF-R1), a prototypic member of the death family, mediates pleiotropic biological outcomes ranging from inflammation and cell proliferation to death. Although many elements specific signaling pathways have been identified, main question how these selective fate decisions are regulated is still unresolved. Here we identified TNF-induced K63 ubiquitination TNF-R1 mediated ubiquitin ligase RNF8 as an early molecular checkpoint in regulation...
The involvement of ceramide in death receptor-mediated apoptosis has been widely examined with most studies focusing on the role generated from sphingomyelin hydrolysis. We now analyze effect acyl chain length by studying tumor necrosis factor α receptor-1 (TNFR1)-mediated a synthase 2 (CerS2) null mouse, which cannot synthesize very-long ceramides. CerS2 mice were resistant to lipopolysaccharide/galactosamine-mediated fulminant hepatic failure even though TNFα secretion macrophages was...
// Jürgen Fritsch 1 , Ricarda Fickers Jan Klawitter Vinzenz Särchen Philipp Zingler Dieter Adam Ottmar Janssen Eberhard Krause 2 Stefan Schütze Institute of Immunology, Christian-Albrechts-University Kiel, Germany Leibniz for Molecular Pharmacology, Berlin, Correspondence to: Fritsch, email: Juergen.Fritsch@uksh.de Keywords: TNF-R1, apoptosis, HSP90, cathepsin D Received: August 08, 2016 Accepted: September 20, Published: October 03, ABSTRACT During apoptosis induction by TNF, the extrinsic...
Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology clinical conditions including ischemia-reperfusion injury, myocardial infarction, sepsis, multiple sclerosis. In particular, kinase activity receptor-interacting serine/threonine protein 1 (RIPK1) is crucial for fate in inflammation death. However, despite its involvement pathological conditions, no pharmacologic inhibitor RIPK1-mediated death currently use. Herein, we screened a...
An ab initio linear-response approach based on the density-functional theory has been used to investigate dynamics of bulk InP and InP(110) surface. The plane-wave pseudopotential method together with slab supercell description for surface have employed in order determine complete phonon spectrum, atomic geometry surface, dispersion a consistent formalism. calculated structural dynamical properties both compare very well all available experimental data. Furthermore, we examine influence...
In Rhodobacter capsulatus wild-type strains, the 23S rRNA is cleaved into [16S] and [14S] molecules. Our data show that a region predicted to form hairpin-loop structure removed from during this processing step. We have analyzed of in wild type mutant strain Fm65, which does not cleave rRNA. addition lack processing, Fm65 shows impeded larger 5.6-kb precursor slow maturation 16S rRNAs pre-23S pre-16S species. Similar effects also been described previously for Escherichia coli RNase III...
Recently, a type of regulated necrosis (RN) called necroptosis was identified to be involved in many pathophysiological processes and emerged as an alternative method eliminate cancer cells. However, only few studies have elucidated components TRAIL-mediated useful for anticancer therapy. Therefore, we compared this cell death tumor factor (TNF)-mediated found similar signaling through acid neutral sphingomyelinases, the mitochondrial serine protease HtrA2/Omi, Atg5, vacuolar H+-ATPase....
The functional plasticity and anti-tumor potential of human γδ T cells have been widely studied. However, the epigenetic regulation T-cell/tumor cell interactions has poorly investigated. In present study, we show that treatment with histone deacetylase inhibitor Valproic acid (VPA) significantly enhanced expression and/or release NKG2D ligands MICA, MICB ULBP-2, but not ULBP-1 in pancreatic carcinoma line Panc89 prostate PC-3. Under vitro tumor co-culture conditions, full length truncated...
Since completion of genome sequencing the malarial parasite Plasmodium falciparum, proteomic tools for identification proteins have become particularly attractive as they allow a more thorough interpretation these data. Recent advances in 2-D PAGE, MS, and bioinformatics created great opportunities mapping characterization protein populations. We employed improvements approach analysis detected two blood stages P. (i) schizont stage (ii) merozoite stage. For isolation merozoites, we...
Here we describe a novel approach for the isolation and biochemical characterization of pathogen-containing compartments from primary cells: We developed lipid-based procedure to magnetically label surface bacteria visualized by scanning transmission electron microscopy (SEM, TEM). performed infection experiments with labeled Mycobacterium avium, M. tuberculosis Listeria monocytogenes isolated magnetic bacteria-containing phagosomes using strong field in free-flow system. Magnetic labeling...