A5027231574- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Vitamin D Research Studies
- Adrenal Hormones and Disorders
Paracelsus Medizinische Privatuniversität
2022-2025
In treating cancer, immunotherapy has been established as a later-line treatment option in clinical practice. That includes stem cell transplantation, modified or activated immune cells, and antibodies directed against aberrant cells. As an unconventional subgroup, γδ T cells have shown to provide effects malignant They exhibit MHC-independent activation process, which could diminish graft-versus-host disease after adoptive transfer of allogeneic Over the last years, efficacy therapeutic...
The transformation of chronic lymphocytic leukemia to an aggressive lymphoma, called Richter transformation, is often accompanied by resistance chemotherapy and high mortality. Thus, novel therapeutic strategies are required for the successful treatment these patients. One possibility cellular immunotherapy with chimeric antigen receptor T cells. However, time delay until cells available limited number effector due impaired immune system patients potentially compromises efficacy this...
γδ T cells, with their properties of both the innate and acquired immune systems, are suitable candidates for cellular immunotherapy in cancer. Because non-major histocompatibility complex (MHC) binding cell receptor, allogenic transfer is feasible without relevant graft versus host reactions. In recent years, much experience has been gained ex vivo expansion stimulation cells using bisphosphonates Interleukin 2. Unfortunately, many current protocols based on use xenogenic materials other...
The immune modulatory effects of vitamin D and the impact deficiency on various diseases are a subject current scientific research. However, there few data directly linking to hard endpoints in clinical studies, apart from its well-known bone health. It is therefore interest, that effectiveness therapeutic antibody rituximab connected serum level patients with B cell lymphomas. Rituximab exerts effect via dependent mediated cytotoxicity (ADCC), NK cells γδ T acting as effector cells. Here we...