A5080579201- MicroRNA in disease regulation
- Hematological disorders and diagnostics
- Cold Atom Physics and Bose-Einstein Condensates
- Probiotics and Fermented Foods
- Clinical Nutrition and Gastroenterology
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Flexible and Reconfigurable Manufacturing Systems
- Immune Cell Function and Interaction
- Genital Health and Disease
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Circular RNAs in diseases
- Advanced Frequency and Time Standards
- Meat and Animal Product Quality
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Chromatin Remodeling and Cancer
- Animal Nutrition and Physiology
- Atomic and Subatomic Physics Research
- Digestive system and related health
- Corporate Governance and Management
- RNA Research and Splicing
- Frailty in Older Adults
- TGF-β signaling in diseases
Nuremberg Hospital
2021-2024
Klinikum Arnsberg
2024
Universität Ulm
2023
Center for Integrated Quantum Science and Technology
2023
Paracelsus Medizinische Privatuniversität
2021-2022
University Hospital of Bern
2022
University Cancer Center Hamburg
2022
University of Bern
2022
German Cancer Research Center
2014-2021
Heidelberg University
2014-2021
The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins which some are specifically expressed high levels in the glands and constitute major components saliva. Here we report on recurrent rearrangements [t(4;9)(q13;q31)] AciCC that translocate active enhancer regions from SCPP to region upstream Nuclear Receptor Subfamily 4 Group A Member 3...
Recent advances in cancer biology have emerged important roles for microRNAs (miRNAs) regulating tumor responses. However, their function mediating intercellular communication within the microenvironment is thus far poorly explored. Here, we found miR-206 to be abrogated human pancreatic ductal adenocarcinoma (PDAC) specimens and cell lines. We show that directly targets oncogenes KRAS annexin a2 (ANXA2), thereby acting as suppressor PDAC cells by blocking cycle progression, proliferation,...
Abstract Aggressive breast cancer is associated with poor patient outcome and characterized by the development of tumor cell variants that are able to escape from control immune system or resistant targeted therapies. The complex molecular mechanisms leading therapy resistance incompletely understood. We have previously shown high miR-519a-3p levels survival in cancer. Here, we demonstrate confers apoptosis induced TRAIL, FasL granzyme B/perforin interfering signaling cells. MiR-519a-3p...
The tumor microenvironment (TME) has an impact on breast cancer progression by creating a pro-inflammatory milieu within the tumor. However, little is known about roles of miRNAs in cells TME during this process. We identified six putative oncomiRs dataset, all strongly correlating with poor overall patient survival. Out candidates, miR-1246 was upregulated aggressive subtypes and expressed at highest levels mesenchymal stem/stroma (MSCs). Functionally, led to p65-dependent increase...
High plasticity is a hallmark of mesenchymal stem cells (MSCs), and as such, their differentiation activities may be shaped by factors microenvironment. Bones, tumors cardiomyopathy are examples niches conditions that contain MSCs enriched with tumor necrosis factor α (TNFα) transforming growth β1 (TGFβ1). These two cytokines generally considered having opposing roles in regulating immunity inflammation (pro- anti-inflammatory, respectively). Here, we performed global gene expression...
Single-photon transitions are one of the key technologies for designing and operating very-long-baseline atom interferometers tailored terrestrial gravitational-wave dark-matter detection. Since such setups aim at detection relativistic beyond-Standard-Model physics, analysis interferometric phases as well atomic diffraction must be performed to this precision including these effects. In contrast, most treatments focused on idealized so far. Here, we study single-photon transitions, both...
Breast cancer is the most common in women worldwide. The tumor microenvironment contributes to progression by inducing cell dissemination from primary and metastasis. TGF β signaling involved breast specifically elevated during metastatic transformation aggressive cancer. In this study, we performed genomewide correlation analysis of TGFBR 2 expression a panel 51 lines identified that MET coregulated with . This was confirmed at protein level human tissues. Flow cytometric luminal basal‐like...
The transformation of chronic lymphocytic leukemia to an aggressive lymphoma, called Richter transformation, is often accompanied by resistance chemotherapy and high mortality. Thus, novel therapeutic strategies are required for the successful treatment these patients. One possibility cellular immunotherapy with chimeric antigen receptor T cells. However, time delay until cells available limited number effector due impaired immune system patients potentially compromises efficacy this...
Zusammenfassung Insgesamt 48 Kreuzungsferkel (DL × P) wurden nach einem Wachstumsversuch von 42 Tagen geschlachtet und der Inhalt Duodenum, Jejunum, Ileum, Caecum Colon auf mögliche Veränderungen Keimzahlen Laktobazillen/Bifidobakterien, Eubacteria, Bacteroidaceae, E. coli Enterokokken untersucht. Als Zulagen dem Futter neben einer Kontrollgruppe 1,25% Ameisensäure oder äquivalent im Säureanionengehalt 1,8% Calciumformiat (Cafo) zugelegt. Diese drei Behandlungen zudem ohne bzw. mit 2%...
Zusammenfassung Nach einem Wachstumsversuch von 41 Tagen wurden 45 Kreuzungsferkel (DL × P) geschlachtet und der Inhalt Duodenum, Jejunum, Ileum, Caecum Colon auf mögliche Veränderungen Keimzahlen Laktobazillen/Bifidobakterien, Eubacteria, Bacteroidaceae, E. coli Enterokokken durch den Zusatz Ameisensäure zum Futter untersucht. Dem wurde neben einer Negativkontrolle in Dosierung 0,6%, 1,2%, 1,8% 2,4% zugelegt. In Abschnitten des Dünndarms die Eubacteria Bacteroidaceae Ameisensäure‐Zulagen...
Zusammenfassung Insgesamt 48 Kreuzungsferkel (DL × P) wurden nach einem Wachstumsversuch von 42 Tagen geschlachtet und der Inhalt Duodenum, Jejunum, Ileum, Caecum Colon auf mögliche Veränderungen in den Keimrelationen Laktobazillen/Bifidobakterien, Eubacteria, Bacteroidaceae, E. coli, Enterokokken Passanten zueinander untersucht. Als Zulagen dem Futter neben einer Kontrollgruppe 1,8% Fumarsäure (Fms), 1,4% Salzsäure (HCl), Natriumformiat (Nafo), 40 ppm Tylosin 50 Toyocerin (0,5 Mio. cfu B....
The incidence of aggressive B-cell lymphomas increases with age, but for elderly or frail patients not eligible doxorubicin-containing treatment standard therapy remains to be defined. In this prospective, multicenter, phase-2 B-R-ENDA trial, we investigated the feasibility, toxicity, and efficacy 8 cycles rituximab combined 6 bendamustine (BR) in lymphoma patients: 39 aged >80 years 29 61–80 elevated Cumulative Illness Rating Scalescore >6 were included. Progression-free survival...
After a feeding trial of 42 days with 4 x 12 piglets 6 were slaughtered and the influence spores Bacillus cereus strain FH 1457 S added to feed on microorganism counts Lactobacillus/Bifidobacterium, Eubacteria, Bacteroidaceae, E. coli, Enterococcus passants (Bacillus cereus) in duodenum, jejunum, ileum, caecum colon was investigated. Beside negative control supplemented 10(7), 10(8) 10(9) CFU cereus/kg. The included two periods each 21 days. In period faeces collected from all animals also...
Diagnostisch ist die Knochenmarkpunktion bei unklaren Blutbildveränderungen noch immer der Goldstandard. Neben korrekten Durchführung jedoch auch Kommunikation mit dem Patienten essenziell.
Objectives: In patients with symptomatic peripheral arterial occlusive disease (PAOD), endovascular revascularization of the superficial femoral artery (SFA) is most frequent intervention. A major drawback procedures clinically driven target lesion (CD-TLR), which may cause recurrence symptoms, re-hospitalizations, and re-interventions. Outcome studies comparing modalities are heterogeneous focus more on intraoperative rather than preoperative aspects. Studies have not examined potential...
Abstract microRNAs (miRNAs) sind kleine, nicht für Proteine codierende RNAs, die wichtige biologische Prozesse regulieren. Neben Funktionen in der natürlichen Entwicklung von Lebewesen auch Beteiligungen an Kranksheitsprozessen wie Krebs beschrieben worden. Diese Regulation erfolgt durch Basenpaarung mit mRNAs Zielgenen, und führt entweder zu deren Abbau oder einer Blockade Herstellung diesen codierten Proteinen. Da innerhalb miRNAs nur eine sehr kurze, etwa 6‐7 Nukleotide lange...
Single-photon transitions are one of the key technologies for designing and operating very-long-baseline atom interferometers tailored terrestrial gravitational-wave dark-matter detection. Since such setups aim at detection relativistic beyond-Standard-Model physics, analysis interferometric phases as well atomic diffraction must be performed to this precision including these effects. In contrast, most treatments focused on idealized so far. Here, we study single-photon transitions, both...