A5109986348- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Atmospheric Ozone and Climate
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Atmospheric chemistry and aerosols
- Immunotherapy and Immune Responses
- Atmospheric aerosols and clouds
- Meteorological Phenomena and Simulations
- T-cell and B-cell Immunology
- Atmospheric and Environmental Gas Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Precipitation Measurement and Analysis
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- Climate variability and models
- Histone Deacetylase Inhibitors Research
- Ionosphere and magnetosphere dynamics
- Retinoids in leukemia and cellular processes
- Cytomegalovirus and herpesvirus research
Saarland University
2015-2024
Westpfalz Klinikum
2018-2024
Universitätsklinikum des Saarlandes
2010-2024
Universidade Estadual Paulista (Unesp)
2010-2022
University Hospital of Lausanne
2022
Klinikum St. Georg
2014
University Hospital Ulm
2012-2014
Leipzig University
2014
Klinikum Chemnitz
2014
Asklepios Klinik St. Georg
2013-2014
To evaluate the prognostic value of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) NPM1 mutation (NPM1(mut)).RNA-based real-time quantitative polymerase chain reaction (RQ-PCR) specific for detection six different NPM1(mut) types was applied to 1,682 samples (bone marrow, n = 1,272; blood, 410) serially obtained from 245 intensively treated younger adult who were 16 60 years old.NPM1(mut) transcript levels as a continuous variable significantly associated...
R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) is standard care for aggressive B-cell lymphoma. A prospective trial was conducted to investigate the role of additive radiotherapy (RT) bulky extralymphatic disease.The best arm RICOVER-60 (6×R-CHOP-14+2R [R-CHOP administered once every 2 weeks two additional applications rituximab] involved-field RT [36 Gy] sites initial [≥ 7.5 cm] disease involvement) compared with a cohort receiving same immunochemotherapy...
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Based on histopathological examination of 264 exocrine pancreatic tumours (167 autopsy and 97 surgical) from the files Institute Pathology, University Hamburg, over a 15‐yr period (1966–1980), histogenetic classification is proposed. In addition to more common neoplasms this also includes rarer recently defined entities. Of tumours, 250 were duct origin, 10 acinar four uncertain histogenesis. Ductal adenocarcinoma, subdivided into well‐differentiated poorly‐differentiated type, was most...
Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I molecules are currently being used in cancer patients elicit stronger T cell responses. However, it remains unclear as how alterations of anchor residues may affect receptor (TCR) recognition. We correlate functional, thermodynamic, and structural parameters TCR–peptide–MHC demonstrate the effect residue modifications human leukocyte antigens (HLA)–A2 tumor epitope NY–ESO-1157–165–SLLMWITQC on TCR The...
Purpose The tet oncogene family member 2 (TET2) gene was recently identified to be mutated in myeloid disorders including acute leukemia (AML). To date, there is increasing evidence for a functional role of TET2 mutations (TET2 mut ) AML. Thus, we explored the frequency, gene-expression pattern, and clinical impact large cohort patients with AML context other AML-associated aberrations. Patients Methods Samples from 783 younger adult were analyzed presence (coding exons 3 11), results...
To investigate the impact and mechanisms of vitamin D deficiency (VDD) on outcome elderly patients with diffuse large B-cell lymphoma (DLBCL).Three hundred fifty-nine pretreatment 25-hydroxyvitamin D3 (25[OH]D3) serum levels from RICOVER-60 study (Six Versus Eight Cycles Biweekly CHOP-14 With or Without Rituximab in Elderly Patients Aggressive CD20+ B-Cell Lymphomas) 63 RICOVER-noRTh (an amendment to which received six cycles cyclophosphamide, doxorubicin, vincristine, prednisone...
Abstract. Accurate long-term monitoring of total ozone is one the most important requirements for identifying possible natural or anthropogenic changes in composition stratosphere. For this purpose, NDACC (Network Detection Atmospheric Composition Change) UV-visible Working Group has made recommendations improving and homogenizing retrieval columns from twilight zenith-sky visible spectrometers. These instruments, deployed all over world about 35 stations, allow measuring twice daily with...
To study clinical presentation, outcome, and the role of radiotherapy in patients with aggressive B-cell lymphoma skeletal involvement treated without rituximab.Outcome was analyzed a retrospective nine consecutive prospective trials German High-Grade Non-Hodgkin Study Group.Of 3,840 patients, 292 (7.6%) had involvement. In MabThera International Trial (MInT) for young good-prognosis Rituximab With CHOP Over 60 Years (RICOVER-60) elderly randomized addition rituximab improved event-free...
We studied 1696 patients (18 to 61 years) with acute myeloid leukemia for ASXL1 mutations and identified these in 103 (6.1%) patients.ASXL1 were associated older age (P<0.0001),male sex (P=0.041),secondary (P<0.0001), lower values bone marrow (P<0.0001) circulating (P<0.0001)blasts.ASXL1 occurred all cytogenetic risk-groups; normal karyotype (40%), other intermediate-risk cytogenetics (26%), high-risk (24%) low-risk (10%) cytogenetics.ASXL1 RUNX1 IDH2 R140 (P=0.007),whereas there was an...