A5068020609- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- CNS Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
- Amyotrophic Lateral Sclerosis Research
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Reproductive System and Pregnancy
- Multiple Myeloma Research and Treatments
- Medical Imaging Techniques and Applications
- Psoriasis: Treatment and Pathogenesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
Saarland University
2015-2024
Universitätsklinikum des Saarlandes
2021-2024
Istituto Giannina Gaslini
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2023
University Medical Center
2023
Lund University
2021
Goethe University Frankfurt
2018
Patients with pre-existing comorbidities and immunosuppression are at greater risk for SARS-CoV-2 infection severe manifestations of COVID-19. This also includes cancer patients, who shown to have a poor prognosis after infection. Here, we describe the case 72-year old male patient B-cell depletion maintenance treatment rituximab non-Hodgkin-lymphoma had prolonged COVID-19 course initial false negative test results. Our highlights diagnostic pitfalls in diagnosing depleted patients discuss...
T-cell/histiocyte-rich large B-cell lymphoma is a rare aggressive showing histopathological overlap with nodular lymphocyte-predominant Hodgkin lymphoma. Despite differences in tumor microenvironment and clinical behavior, the cells of both entities show remarkable similarities, suggesting that lymphomas might represent spectrum same disease. To address this issue, we investigated whether these share mutations. Ultra-deep targeted resequencing six typical 11 variants lymphoma, nine cases...
Abstract Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare of B-cell origin with frequent expression functional receptors (BCRs). Here we report that cloning followed by antigen screening identifies DNA-directed RNA polymerase beta’ (RpoC) from Moraxella catarrhalis as BCRs IgD + LP cells. Patients show predominance HLA-DRB1*04/07 and the IgVH genes encode extraordinarily long CDR3s. High-titer, light-chain-restricted anti-RpoC IgG1/κ-type serum-antibodies are additionally...
Recipients of allogeneic stem cell transplantation (alloSCT) are at high risk for contracting infectious diseases with morbidity and mortality. Coronavirus disease 2019 (COVID-19) is a viral respiratory that can lead to severe pneumonia acute distress syndrome, potentially fatal outcome. In this retrospective study conducted on behalf the German Cooperative Transplant Study Group, we aimed analyze factors, course, outcomes COVID-19 in patients who underwent alloSCT. AlloSCT recipients became...
Progranulin (PGRN), Total-Tau (t-tau), and Neurofilament light chain (NfL) are well known biomarkers of neurodegeneration. The objective the present study was to investigate whether these parameters represent also in autoimmune-mediated Encephalitis (AE) may give us insights into pathomechanisms AE. We retrospectively examined concentration PGRN cerebrospinal fluid (CSF) serum 38 patients suffering from AE acute phase and/or under treatment. This cohort comprises with autoantibodies against:...
Fluorine-18 fluorodeoxyglucose positron emission tomography combined with computed (FDG PET/CT) is the standard for staging aggressive non-Hodgkin lymphoma (NHL). Limited data from prospective studies available to determine whether initial by FDG PET/CT provides treatment-relevant information of bone marrow (BM) involvement (BMI) and thus could spare BM biopsy (BMB).
Abstract Background Adult-onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (sJIA) resemble a continuum of rare, polygenic IL-1β-driven unknown etiology. Objective In the present study we sought to investigate potential role recently described autoantibodies neutralizing interleukin-1(IL-1)-receptor antagonist (IL-1-Ra) in pathogenesis disease. Methods Serum or plasma samples from patients (AOSD, n = 23; sJIA, 40) autoimmune and/or inflammatory controls ( 478) were...
Patients with large B-cell lymphoma (LBCL) who experience relapsed disease after CD19-directed CAR T-cell therapy (CAR-T) have a poor prognosis. Bispecific antibodies (BsAbs) induce complete remissions in approximately 35% of these cases. Hypothesizing overlapping LBCL-intrinsic resistance mechanisms as well common prognosis predictors to CAR-T and BsAb therapy, we conducted multicenter retrospective analysis including 92 relapsed/refractory (r/r) LBCL patients treated failure. Overall...
Introduction Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious complication associated with SARS-CoV-2. Although the crucial pathogenic role of monocyte compartment known, information regarding mechanisms and maintenance trigger lacking. Genetic variants OAS/RNase L pathway, involved viral double-stranded RNA (dsRNA) sensing modulation responses, have been identified patients MIS-C. We conducted comprehensive analysis, including study NLRP3 inflammasome...
Psoriatic arthritis (PsA) is a distinctive inflammatory which may typically develop in subgroup of individuals suffering from psoriasis. We recently described progranulin autoantibodies (PGRN-Abs) the sera patients with different autoimmune diseases including seronegative polyarthritis. In present study we investigated occurrence PGRN-Abs PsA.PGRN-Abs were determined 260 PsA, 100 psoriasis without arthritic manifestations (PsC) and 97 healthy controls using ELISA. PGRN plasma levels...
Background: Analysis of cerebrospinal fluid (CSF) has improved over the last few years; thus specific markers for different diseases have emerged, e.g., amyloid-β (Aβ) Alzheimer's disease (AD) and progranulin frontotemporal dementia (FTD). Objective: Evaluation correlation between biomar kers in CSF cognitive performance populations with AD FTD. Methods: 27 patients 16 FTD were included. tau, P-tau181P, Aβ42, (PGRN) measured a standardized neuropsychological test battery applied. Olfactory...
Immunological memory is important to protect humans against recurring diseases. Memory CD8+ T cells are required for quick expansion into effector but also provide immediate cytotoxicity their targets. Whereas many functions of the two main cytotoxic subtypes, (TEM) and central (TCM), well defined, single TEM TCM cell has not been quantified. To quantify efficiency TCM, we developed a FRET-based fluorescent assay with NALM6 target which allows analysis apoptosis, secondary necrosis following...
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a expressing functional B-cell receptors (BCR). Recently, we described dual stimulation model of IgD+ cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 HLA-DRB1*04 or HLADRB1* 07 haplotype. The aim the present study was to extend screening further bacteria viruses. fragment antibody-binding (Fab) regions seven new 15 previously reported cases were analyzed. reactivity...
UNFOLDER (NCT00278408, EUDRACT 2005-005218-19) is a phase-3 trial in patients with aggressive B-cell lymphoma and intermediate prognosis, including primary mediastinal (PMBCL). In 2 × factorial design, were randomized to 6× R-CHOP-14 or R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, prediso(lo)ne) consolidation radiotherapy extralymphatic/bulky disease observation. Response was assessed according the standardized criteria from 1999, which did not include F-18...