Robert Zeiser
A5084803299- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Melanoma and MAPK Pathways
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Protein Degradation and Inhibitors
- Lymphoma Diagnosis and Treatment
- Pancreatic function and diabetes
University of Freiburg
2016-2025
University Medical Center Freiburg
2016-2025
German Cancer Research Center
2010-2024
Heidelberg University
2010-2024
Deutschen Konsortium für Translationale Krebsforschung
2018-2023
German Marine Research Consortium
2022
University of Fribourg
2020
London Cancer
2019
University College London
2019
European Institute of Oncology
2019
Acute graft-versus-host disease (GVHD) remains a major limitation of allogeneic stem-cell transplantation; not all patients have response to standard glucocorticoid treatment. In phase 2 trial, ruxolitinib, selective Janus kinase (JAK1 and JAK2) inhibitor, showed potential efficacy in with glucocorticoid-refractory acute GVHD.
PURPOSE Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT), patients with acute myeloid leukemia (AML) internal tandem duplication mutation in the FMS-like tyrosine kinase 3 gene ( FLT3-ITD) have a poor prognosis, frequently relapse, and die as result of AML. It is currently unknown whether maintenance therapy using FLT3 inhibitors, such multitargeted inhibitor sorafenib, improves outcome after HCT. PATIENTS AND METHODS In randomized, placebo-controlled, double-blind...
Chronic graft-versus-host disease (GVHD), a major complication of allogeneic stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in approximately 50% patients. Robust data from phase 3 randomized studies evaluating second-line therapy for chronic GVHD are lacking. In retrospective surveys, ruxolitinib, Janus kinase (JAK1–JAK2) inhibitor, showed potential efficacy patients with -dependent GVHD.
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid development of novel immunological interventions, we studied breadth, frequency, tumor-infiltration naturally occurring CD8+ T-cell responses targeting several tumor-associated antigens (TAA). We used overlapping peptides spanning entire alpha-fetoprotein (AFP), glypican-3 (GPC-3), melanoma-associated gene-A1 (MAGE-A1) New York-esophageal squamous cell...
The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host disease (GvHD), a severe complication accompanied high mortality rates. Yet, the molecular mechanisms initiating this remain poorly defined. In study, we show that, after conditioning therapy, intestinal commensal bacteria and damage-associated pattern uric acid contribute to Nlrp3 inflammasome–mediated IL-1β production that gastrointestinal decontamination depletion reduced GvHD severity....
Oncogenic JAK mutation sensitizes myeloproliferative neoplasms to immune checkpoint inhibition.
Abstract Mutational inactivation of VHL is the earliest genetic event in majority clear cell renal carcinomas (ccRCC), leading to accumulation HIF-1α and HIF-2α transcription factors. While correlative studies human ccRCC functional using lines have implicated as an inhibitor a promoter aggressive tumour behaviours, their roles onset not been functionally addressed. Herein we show autochthonous model that Hif1a essential for formation whereas Hif2a deletion has only minor effects on...