A5021664459- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Signaling Pathways in Disease
- T-cell and B-cell Immunology
- DNA Repair Mechanisms
- Neonatal and Maternal Infections
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Autoimmune Neurological Disorders and Treatments
- Protein Tyrosine Phosphatases
- Biochemical and Structural Characterization
- ATP Synthase and ATPases Research
- Nosocomial Infections in ICU
- Inflammatory Bowel Disease
- Galectins and Cancer Biology
Humboldt-Universität zu Berlin
2024
Charité - Universitätsmedizin Berlin
2017-2024
Freie Universität Berlin
2024
German Rheumatism Research Centre
2017-2024
University of Freiburg
2012-2021
University Medical Center Freiburg
2012-2018
Tissue Gene (United States)
2010
Hospital for Special Surgery
2007-2010
National and Kapodistrian University of Athens
2004-2007
Montefiore Medical Center
2005-2006
ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, TNF, from the cell surface, thus regulating responses to tissue injury inflammation. However, little currently known about its role in skin homeostasis. We show that mice lacking keratinocytes (A17(ΔKC)) have a normal barrier architecture at birth but develop pronounced defects integrity soon after chronic dermatitis adults....
Glomerulonephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Although substantial progress has been made the identification pathogenic triggers that result autoantibody production, little known about pathogenesis aggressive proliferative processes lead directly to irreversible glomerular damage and compromise renal function. In this study, we describe model polyinosinic: polycytidylic acid-accelerated nephritis NZB/W mice characterized by severe lesions de...
Article19 June 2018Open Access Source DataTransparent process Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney Amandine Viau Renal Department, University Medical Center, Freiburg, Germany Faculty of Medicine, INSERM U1151, Institut Necker Enfants Malades, Department Growth Signaling, Université Paris Descartes-Sorbonne Cité, Paris, France Search for more papers by this author Frank Bienaimé Service d'Explorations Fonctionnelles,...
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, molecular mechanisms failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in cells (IECs) patients with IBD and show that impaired sufficient to drive chronic inflammation. We found reduced expression fusion–related genes, such as dynamin-related guanosine triphosphatase (GTPase) optic atrophy 1 ( OPA1 ), fragmented networks crypt IECs IBD. Mice Opa1...
Primary Sjögren's syndrome (SS) is an autoimmune disease characterized by activation of minor salivary gland (MSG) epithelial cells and B T lymphocytic infiltrates. These findings have long encouraged the hypothesis that a persistent viral infection MSG may drive response; however, identity virus has remained elusive. The aim this study was to test hypothesis.We applied differential display protocol RNA samples from patients with primary SS healthy controls. We then used seminested reverse...
Analyzing immune cell interactions in the bone marrow is vital for understanding hematopoiesis and homeostasis. Three-dimensional analysis of complete, intact within cortex whole long bones remains a challenge, especially at subcellular resolution. We present method that stabilizes provides resolution fluorescent signals throughout murine femur, enabling identification spatial characterization hematopoietic stromal subsets. By combining pre-processing algorithm stripe artifact removal with...
Interleukin-27 (IL-27) has stimulatory and regulatory immune functions is expressed in rheumatoid arthritis (RA) synovium. This study was undertaken to investigate the effects of IL-27 on human osteoclastogenesis, determine whether can stimulate or attenuate osteoclast-mediated bone resorption that a hallmark RA.Osteoclasts were generated from blood-derived CD14+ cells. The osteoclast formation evaluated by counting number tartrate-resistant acid phosphatase-positive multinucleated cells...
Abstract The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that result from Toll-like receptor-induced DNA damage and cell autonomous cycle modifications. However, the progenitor identity remained unclear. Here, we show cell-forming potential particular trait of monocyte progenitors. Common progenitors potently produce cytokines in their immune-active molecules. In addition,...
Group B streptococci (GBS; Streptococcus agalactiae) are a major cause of invasive infections in newborn infants and patients with type 2 diabetes. Both patient groups exhibit peripheral insulin resistance alterations polymorphonuclear leukocyte (PML) function. In this investigation, we studied the PML response repertoire to GBS focus on TLR signaling modulation by mice humans. We found that GBS-induced, MyD88-dependent chemokine formation was specifically downmodulated via receptor-mediated...
A pivotal role of type I interferons in systemic lupus erythematosus (SLE) is widely accepted. Type III (IFN-λ) however, the most recently discovered cytokines grouped within interferon family, have not been extensively studied disease models yet. Growing evidence suggests a for IFN-λ regulating both innate and adaptive immune responses, increased serum concentrations described multiple autoimmune diseases including SLE. Using pristane-induced model, we found that mice with defective...
Abstract Background and Aims Fistula formation is a major complication in Crohn’s disease [CD] the role of immune cell compartment remains to be elucidated. Thus, we compared CD fistula inflammatory colitis using imaging mass cytometry [IMC] immunofluorescence. Methods A 36-marker panel including structural, functional, lineage markers for use IMC was established. This applied analyse paraffin-embedded tract [n = 11], 10], colon samples from non-inflamed controls 12]. Computational methods...