A5032710079- Immune cells in cancer
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Receptor Mechanisms and Signaling
- COVID-19 Impact on Reproduction
- Blood disorders and treatments
- Tryptophan and brain disorders
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- interferon and immune responses
- COVID-19 and Mental Health
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Cancer Mechanisms and Therapy
University Medical Center Freiburg
2013-2024
University of Freiburg
2017-2024
University Medical Center
2020
The skin needs to balance tolerance of colonizing microflora with rapid detection potential pathogens. Flexible response mechanisms would seem most suitable accommodate the dynamic challenges effective antimicrobial defense and restoration tissue homeostasis. Here, we dissected macrophage-intrinsic microenvironmental cues that tune macrophage signaling in localized infection opportunistic pathogen Staphylococcus aureus. Early infection, cytokine granulocyte-macrophage colony-stimulating...
Abstract The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that result from Toll-like receptor-induced DNA damage and cell autonomous cycle modifications. However, the progenitor identity remained unclear. Here, we show cell-forming potential particular trait of monocyte progenitors. Common progenitors potently produce cytokines in their immune-active molecules. In addition,...
Dermal macrophages (macs) protect the skin from invading pathogens. They are derived embryonic as well hematopoietic progenitors. However, functional impact of their diverse origin and control networks defining different subsets remain unclear. Here, using multidimensional analysis dermal macs, we reveal that absence circulating monocytes in interferon regulatory factor 8 (Irf8) deficient mice delays mac renewal during steady state. Yet, mosaic macs remains largely intact, i.e., major...
Macrophages play integral roles in maintaining homeostasis and function their tissues of residence. In the skin, prenatally seeded highly specialized macrophages physically interact with sensory nerves contribute to regeneration after injury. However, mechanisms underlying development maintenance this potentially lifelong commitment nociceptors remain largely elusive. Here, we found that infiltrating myeloid progenitor cells approached sprouting axons gradually adopted a nerve-associated...
Bona fide Kupffer cells (KCs) are prenatally seeded and show unique functional immunophenotypic features among tissue macrophages. They considered as terminally differentiated, adaptability in disease is attributed to recruited, monocyte-derived KCs. Here, we investigated the extent of KC plasticity impact origin mycobacterial infections that target macrophages can persist for months. Fate-mapping combined with high-resolution imaging revealed emergence a unique, infection specific subset...
Staphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. most frequent cause soft tissue infections. Dermal macrophages (Mφ) are critical for coordinated defense against invading aureus, yet they have limited life span with replacement by bone marrow derived monocytes. It currently poorly understood whether localized infections persistently alter resident Mφ subset composition resistance to subsequent infection. In strictly dermal...
For neonates, group B Streptococcus is life threatening. Current prevention strategies remain insufficient, especially for cases of late-onset sepsis, where intrapartum antibiotic prophylaxis has demonstrated no benefit. One promising approach the vaccination pregnant women, which offers protective immunity via transplacental transmission neutralizing antibodies. Our nationwide, prospective surveillance study aimed to characterize prevalence pilus antigen, capsular polysaccharide serotypes,...
Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with C-terminal extension of seven amino acids. The biological significance this NS1 elongation remained elusive. We observed that replication kinetics the wild-type virus A/Hong Kong/01/68 (H3N2) and mutant encoding truncated were indistinguishable most experimental systems. However, outcompeted during mixed infections, suggesting conferred minor growth advantages.
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
1. Abstract Macrophages in the dura mater are substantial contributors to immune defense of brain, however, their site-specific origin and function bacterial infections central nervous system incompletely understood. In a natural model streptococcal meningoencephalitis, where bacteria systemically spread via bloodstream we found streptococci be largely restricted meninges. Further sporadic underlying brain parenchyma caused region-restricted microglia activation. Invasion monocytes, but not...
To elucidate how the clinical presentation of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) was influenced by successive variants concern (VOC) and patient age.
Abstract Purpose Group B streptococcus (GBS) remains a leading cause of invasive disease, mainly sepsis and meningitis, in infants < 3 months age mortality among neonates. This study, major component the European DEVANI project (Design Vaccine Against Neonatal Infections) describes clinical important microbiological characteristics neonatal GBS diseases. It quantifies rate antenatal screening intrapartum antibiotic prophylaxis cases identifies risk factors associated with an adverse...