A5007163430- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Tuberculosis Research and Epidemiology
- Streptococcal Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Dermatology and Skin Diseases
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Bee Products Chemical Analysis
- Parasitic Infections and Diagnostics
- Antifungal resistance and susceptibility
- Entomological Studies and Ecology
- Hair Growth and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Occupational exposure and asthma
- Probiotics and Fermented Foods
- Forensic Toxicology and Drug Analysis
- Respiratory and Cough-Related Research
- Ureteral procedures and complications
National Center of Infectious and Parasitic Diseases
2009-2022
University Hospital Carl Gustav Carus
2022
TU Dresden
2022
National Institute for Biological Standards and Control
1988
ALK-Abelló (Denmark)
1988
Abstract Streptococcus agalactiae (Group B , GBS) is a commensal of the digestive and genitourinary tracts humans that emerged as leading cause bacterial neonatal infections in Europe North America during 1960s. Due to lack epidemiological genomic data, reasons for this emergence are unknown. Here we show by comparative genome analysis phylogenetic reconstruction 229 isolates rise human GBS corresponds selection worldwide dissemination only few clones. The parallel expansion clones preceded...
Medical practice faces serious problems due to the constantly increasing bacterial poly-resistance antibiotics, and side effects of latter, often including allergic immunosuppressive reactions. One way resolve this problem is application immunomodulators that increase resistance viral infections by stimulating non-specific immunity mechanisms. In course more than 20 years a number oral have been developed investigated in NCIPD, Sofia: Respivax, Urostim Dentavax which are widely successfully...
(1) Background: Biomarkers of efficacy for subcutaneous immunotherapy (SCIT) on allergic rhinitis have not been evaluated in details. The present study aims to assess the relevance measuring sIgE, sIgG4 and IgE/IgG4 ratio during SCIT patients with rhinitis; (2) Methods: 20 patients, 13 men 7 women aged 19 58 years, clinically manifested seasonal perennial were studied. At initiation end three-year course serum allergen-specific IgE IgG4 measured ImmunoCAP system. sIgE/sIgG4 was calculated as...
Anti-Echinococcus serum immunoglobulin (Ig)E was assessed by the ImmunoCAP system and compared with anti-Echinococcus IgG enzyme-linked immunosorbent assay (ELISA) Western blot. The revealed very high specificity (one false positive of 110 healthy individuals), low cross-reactivity 58 patients other diseases) decreased sensitivity (73.55%). Receiver operating characteristic analysis displayed a beneficial diagnostic value accuracy. Comparison ELISA blot showed significantly higher lower...
Purpose: Evaluate effects of maternal immunization in a mouse model Group B Streptococcus (GBS) vaginal colonization using clinical isolates.Materials and methods: Female pregnant mice were immunized with heat-killed GBS 21 days before pregnancy inoculated intravaginally cultures (5 × 107 CFU twice day for three days) from the 16th pregnancy. Gestation period survival monitored. Maternal anti-GBS IgG levels have been determined by ELISA analysis vaccinated, unvaccinated mothers...
Background: Two‐flow cytometry methods for quantification of degranulated basophil after allergen‐specific activation were discussed. The are discerned by used membrane receptors – Fc ɛ RI or IL‐3R α Our goal was to evaluate the diagnostic potential and correlate them IgE detection skin prick test (SPT). Methods: Patient's control's groups studied with Bulgarian grass pollen allergen B1 simultaneously flow kits: Basotest BD FastImmune test. Allergy diagnosis based on clinical history SPT....
Introduction. In Bulgaria, mold allergies are common, and sensitization to different fungal species is found in many patients with atopy.The objective of this study explore the most widespread determine extent Alt a1, a major allergen Alternaria alternata, by using component-resolved diagnosis.Materials Methods. 21 (14 males 7 females, age range 5-40 years), respiratory allergy participated study. All sensitized mix allergens containing: Aspergillus sp., Cladosporium herbarum, Penicillium...
The reactivity to food proteins is specific, but in certain patients cross reactions are observed between of plant or animal origin and non-food ones.The most common clinical manifestation this oral allergy syndrome (OAS).It develops mainly with pollen after fresh fruit vegetables consumption.The symptoms oro-pharyngeal pruritus, papules vesicles which resemble mouth ulcers on the labial mucosa labial, palatal lingual swelling.There may also be a sensation pharyngeal swelling.The appear very...
а ллергия на пыльцу деревьев расширяется в европе.Проявления аллергии семейства Betulaceae и сопровождающий ее синдром оральной становятся все более распространенными.оральный аллергический (оаС) диагностируется у 70 % больных с аллергией [10].Поллиноз является наиболее
Abstract To examine the clinical spectrum of complications in pulmonary system and changes some parameters humoral cell mediated immunity related to heroin overdose. The study includes 16 patients who are long-term abusers with acute mixed other psychoactive drugs intoxications an average age 21,5 ± 5.04 years (12 men 4 woman). All were hospitalized Clinic Toxicology, MHATEM “N.I.Pirogov”, Sofia. We have used clinical, clinico-laboratory, immunological, chimicotoxicological, instrumental...
Determination of professional activities, which are connected with higher risk toxocariasis, is very important for well-timed diagnosis and prevention. That why our research aimed to investigate the spread toxocariasis in people, whose activities related forests. Thirty-three people included study – eight employees Forest Research Institute at Bulgarian Academy Sciences, Sofia, 25 forestry workers from three different locations South Bulgaria. The specific parasitological performed ELISA...